2022
DOI: 10.1111/vcp.13085
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Iron, hepcidin, and microcytosis in canine hepatocellular carcinoma

Abstract: Background: Erythrocyte microcytosis in some dogs with hepatocellular carcinoma (HCC) suggests a derangement in systemic iron. Hepcidin, the master regulator of iron, is secreted by the liver in response to interleukin 6 (IL-6) and/or bone morphogenetic protein 6 (BMP6) and can cause microcytosis.Objectives: Pilot study to compare the quantities of hepcidin, IL-6, and BMP6 RNA molecules in archival tumoral (HCC) and adjacent peritumoral (non-HCC) hepatic tissue to determine if they are different between tissue… Show more

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Cited by 1 publication
(2 citation statements)
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References 109 publications
(211 reference statements)
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“…More recently, high intensity focused ultrasound (HIFU) was used to treat pet dogs with solid tumours and nCounter analysis of biopsy samples demonstrated differential expression of 28 genes associated with T‐cell activation following treatment 103 . Several other groups have published gene expression data generated from canine samples using the nCounter platform, and a multitude of studies are ongoing using this tool as part of the PRECINCT consortium 104–106 . It is worth noting that custom panels can be designed to facilitate targeted interrogation.…”
Section: Emerging Technologies and Resourcesmentioning
confidence: 99%
See 1 more Smart Citation
“…More recently, high intensity focused ultrasound (HIFU) was used to treat pet dogs with solid tumours and nCounter analysis of biopsy samples demonstrated differential expression of 28 genes associated with T‐cell activation following treatment 103 . Several other groups have published gene expression data generated from canine samples using the nCounter platform, and a multitude of studies are ongoing using this tool as part of the PRECINCT consortium 104–106 . It is worth noting that custom panels can be designed to facilitate targeted interrogation.…”
Section: Emerging Technologies and Resourcesmentioning
confidence: 99%
“…103 Several other groups have published gene expression data generated from canine samples using the nCounter platform, and a multitude of studies are ongoing using this tool as part of the PRECINCT consortium. [104][105][106] It is worth noting that custom panels can be designed to facilitate targeted interrogation. This approach was recently employed to support validation of an antibody panel designed to distinguish lymphoid versus myeloid lineage leukaemias, demonstrating 100% concordance between flow cytometry and gene expression for the lymphoid leukaemias and 80% concordance for myeloid leukaemias.…”
Section: Spatial Transcriptomicsmentioning
confidence: 99%