Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction

Liu, Jingjing; Chen, Huimin; Lin, Hongkun; Peng, Shufen; Chen, Li; Cheng, Xueer; Yao, Ping; Tang, Yuhan

doi:10.1016/j.jnutbio.2022.109258

Cited by 4 publications

(4 citation statements)

References 53 publications

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“…Quercetin [101] Breast Ca ↑ ATF3 [102], HMOX1 [103] ↓ SLC40A1 [104], FTL [105], SP1 [106] Ruscogenin [31] Pancreas Ca ↑ TF [31,107] ↓ SLC40A1 [107] Salinomycin [108] Head/neck Ca ↑ ATF3 [109], ATF4 [110], ATG5, ATG7 [111], DPP4 [112], IREB2, TFRC [108,113] ↓ FTH1, FTL [113], NFE2L2, GCLC [114], HIF1A [115], TP53 [116], FTH1 [108] Sanguinarine [117,118] Cervical Ca ↓ SLC7A11 [118] Solasonine [31] Liver Ca ↓ GPX4, GSS [119], SLC7A11 [120] Sulforaphane [121] Leukemia…”

Section: Modulation By Natural Products * Ferroptosis-inducing Genes ...mentioning

confidence: 99%

“…In contrast, quercetin was reported to downregulate ferroptosis-inhibiting genes ( SP1 [ 104 ], SLC40A1 [ 104 ], and FTL [ 105 ]), but the impact of ferroptosis was not assessed. In a cancer study, quercetin causes the antiproliferation and apoptosis of malignant pleural mesothelioma by inhibiting the expression of the ferroptosis-inhibiting SP1 gene [ 106 ].…”

Section: Ferroptosis-modulating Natural Productsmentioning

confidence: 99%

“…In non-cancer studies, quercetin downregulates the ferroptosis-inhibiting SLC40A1 gene of colon cancer cells and reduces intestinal iron absorption in rats [ 104 ]. Similarly, quercetin reduces alcohol-fed mice’s liver damage and iron levels by downregulating FTL [ 105 ]. In contrast, other ferroptosis events are rarely investigated in these studies [ 104 , 105 ].…”

Section: Ferroptosis-modulating Natural Productsmentioning

confidence: 99%

“…Similarly, quercetin reduces alcohol-fed mice’s liver damage and iron levels by downregulating FTL [ 105 ]. In contrast, other ferroptosis events are rarely investigated in these studies [ 104 , 105 ]. An assessment of the impact of quercetin treatments on ferroptosis is warranted in these studies.…”

Section: Ferroptosis-modulating Natural Productsmentioning

confidence: 99%

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Ferroptosis-Regulated Natural Products and miRNAs and Their Potential Targeting to Ferroptosis and Exosome Biogenesis

Chuang,

Yen,

Chien

et al. 2024

IJMS

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Ferroptosis, which comprises iron-dependent cell death, is crucial in cancer and non-cancer treatments. Exosomes, the extracellular vesicles, may deliver biomolecules to regulate disease progression. The interplay between ferroptosis and exosomes may modulate cancer development but is rarely investigated in natural product treatments and their modulating miRNAs. This review focuses on the ferroptosis-modulating effects of natural products and miRNAs concerning their participation in ferroptosis and exosome biogenesis (secretion and assembly)-related targets in cancer and non-cancer cells. Natural products and miRNAs with ferroptosis-modulating effects were retrieved and organized. Next, a literature search established the connection of a panel of ferroptosis-modulating genes to these ferroptosis-associated natural products. Moreover, ferroptosis-associated miRNAs were inputted into the miRNA database (miRDB) to bioinformatically search the potential targets for the modulation of ferroptosis and exosome biogenesis. Finally, the literature search provided a connection between ferroptosis-modulating miRNAs and natural products. Consequently, the connections from ferroptosis–miRNA–exosome biogenesis to natural product-based anticancer treatments are well-organized. This review sheds light on the research directions for integrating miRNAs and exosome biogenesis into the ferroptosis-modulating therapeutic effects of natural products on cancer and non-cancer diseases.

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