2011
DOI: 10.1523/jneurosci.2838-11.2011
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Iron Efflux from Oligodendrocytes Is Differentially Regulated in Gray and White Matter

Abstract: Accumulation of iron occurs in the CNS in several neurodegenerative diseases. Iron is essential for life but also has the ability to generate toxic free radicals if not properly handled. Iron homeostasis at the cellular level is therefore important to maintain proper cellular function, and its dysregulation can contribute to neurodegenerative diseases. Iron export, a key mechanism to maintain proper levels in cells, occurs via ferroportin, a ubiquitously expressed transmembrane protein that partners with a fer… Show more

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Cited by 86 publications
(93 citation statements)
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“…Cooperation of Fpn and Hp in supporting iron export from cells endogenous to the CNS has been demonstrated previously (13,29). Here, we have presented evidence that Fpn and Hp cooperate in the process by which iron is released from the barrier cells of the brain, the BMVEC; note that the polarity of this efflux could not be determined in our monolayer system.…”
Section: Discussionmentioning
confidence: 63%
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“…Cooperation of Fpn and Hp in supporting iron export from cells endogenous to the CNS has been demonstrated previously (13,29). Here, we have presented evidence that Fpn and Hp cooperate in the process by which iron is released from the barrier cells of the brain, the BMVEC; note that the polarity of this efflux could not be determined in our monolayer system.…”
Section: Discussionmentioning
confidence: 63%
“…mulation is observed in oligodendrocytes (9,13). This hypothesis is the subject of ongoing research.…”
Section: Discussionmentioning
confidence: 83%
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“…Oligodendrocytes are located in the close vicinity of capillaries [10,22,26]. Already during the second week after birth, the distribution of iron in oligodendrocytes accurately corresponds to the places of myelination, which indicates the functional dependence between iron accumulation and myelin production [1,9,11,15,16]. The above findings were confirmed by Connor et al [11,15,17,18], who demonstrated that the peak iron absorption in the CNS coincides with the peak myelination.…”
Section: Discussionmentioning
confidence: 64%
“…Many hypotheses have been put forward regarding the role of iron in the CNS and the issue still causes heated debates. Initially, the presence of iron in oligodendrocytes was linked with γ-amino butyric acid (GABA) metabolism as elevated levels of iron were correlated with the regions in which GABA is a neurotransmitter [13,14,15,16]. The second hypothesis is based on the presence of iron in oligodendrocytes and myelin, which confirms its involvement in myelination.…”
Section: Introductionmentioning
confidence: 99%