Iron doped carbon dots based nanohybrids as a tetramodal imaging agent for gene delivery promotion and photothermal-chemodynamic cancer synergistic theranostics

Luo, Tianying; Nie, Yu; Lu, Jiao; Bi, Qunjie; Cai, Zhipeng; Xu, Song; Ai, Hua; Jin, Rongrong

doi:10.1016/j.matdes.2021.109878

Cited by 38 publications

(37 citation statements)

References 50 publications

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“…In conclusion, as a therapeutic platform with good biocompatibility and photothermal properties, CDs and metal nanoparticle hybrid materials can be widely used in drug delivery, photothermal/photodynamic therapy, and biological antibacterial treatment elds. [94][95][96] Metal oxide/CDs Metal oxide nanoparticles have attracted much attention due to their stability, relatively low production cost, and functional properties in various elds. 22 Based on the excellent application performance of metal oxide nanoparticles, many researchers compound them with CDs, which have rich surface defects, a wide wavelength range of light absorption, visible solid light absorption, up-conversion luminescence, and other characteristics, to construct a series of CDs and oxide hybrid materials.…”

Section: Metal/cdsmentioning

confidence: 99%

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Carbon dot/inorganic nanomaterial composites

Cai

et al. 2022

J. Mater. Chem. A

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Section: Metal/cdsmentioning

confidence: 99%

Section: Structures and Properties Of Cds/inorganic Nanohybrid Materialsmentioning

confidence: 99%

Carbon dot/inorganic nanomaterial composites

Cai

et al. 2022

J. Mater. Chem. A

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“…With the numerous possible variations of core composition and surface functionalization blended with the capacity for external stimuli enhancements ensure that this research area has plenty of room for novel theragnostic applications. Not only can these particles be used to destroy cancers through photothermal, [ 11 ] chemodynamic, [ 135 ] and immune [ 136 ] based combination therapies, but may also hold promise for the development of healthy bodily systems via regenerative medicinal therapy.…”

Section: Targeted Tumor Deliverymentioning

confidence: 99%

“…The synergistic photothermal and chemodynamic therapy resulted in significantly reduced breast tumor growth and 80% survival within female Balb/c mice for more than 50 days. [ 135 ]…”

Section: Targeted Tumor Deliverymentioning

confidence: 99%

Carbon Dot Therapeutic Platforms: Administration, Distribution, Metabolism, Excretion, Toxicity, and Therapeutic Potential

Truskewycz

Yin

Halberg

et al. 2022

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“…Similarly, there was a two-fold enhancement in the efficacy of gene therapy. Overall, the synergistic therapy resulted in excellent inhibition in tumor growth and 80% survival for 50 days in a mice model of 4T1 breast tumor [ 97 ].…”

Section: Nanozyme Platforms For Anticancer Applicationsmentioning

confidence: 99%

Emerging Prospects of Nanozymes for Antibacterial and Anticancer Applications

et al. 2022

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The ability of some nanoparticles to mimic the activity of certain enzymes paves the way for several attractive biomedical applications which bolster the already impressive arsenal of nanomaterials to combat deadly diseases. A key feature of such ‘nanozymes’ is the duplication of activities of enzymes or classes of enzymes, such as catalase, superoxide dismutase, oxidase, and peroxidase which are known to modulate the oxidative balance of treated cells for facilitating a particular biological process such as cellular apoptosis. Several nanoparticles that include those of metals, metal oxides/sulfides, metal–organic frameworks, carbon-based materials, etc., have shown the ability to behave as one or more of such enzymes. As compared to natural enzymes, these artificial nanozymes are safer, less expensive, and more stable. Moreover, their catalytic activity can be tuned by changing their size, shape, surface properties, etc. In addition, they can also be engineered to demonstrate additional features, such as photoactivated hyperthermia, or be loaded with active agents for multimodal action. Several researchers have explored the nanozyme-mediated oxidative modulation for therapeutic purposes, often in combination with other diagnostic and/or therapeutic modalities, using a single probe. It has been observed that such synergistic action can effectively by-pass the various defense mechanisms adapted by rogue cells such as hypoxia, evasion of immuno-recognition, drug-rejection, etc. The emerging prospects of using several such nanoparticle platforms for the treatment of bacterial infections/diseases and cancer, along with various related challenges and opportunities, are discussed in this review.

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Iron doped carbon dots based nanohybrids as a tetramodal imaging agent for gene delivery promotion and photothermal-chemodynamic cancer synergistic theranostics

Cited by 38 publications

References 50 publications

Carbon dot/inorganic nanomaterial composites

Carbon dot/inorganic nanomaterial composites

Carbon Dot Therapeutic Platforms: Administration, Distribution, Metabolism, Excretion, Toxicity, and Therapeutic Potential

Emerging Prospects of Nanozymes for Antibacterial and Anticancer Applications

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