Iron-dextran as a thermosensitizer in radiofrequency hyperthermia for cancer treatment

Chung, Hea-Jong; Kim, Hyeon Jin; Hong, Seong‐Tshool

doi:10.1186/s13765-019-0432-6

Cited by 14 publications

(7 citation statements)

References 21 publications

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“…Efforts have also been made to stimulate heat absorbance of tumors compared to their microenvironment. Iron-dextran, incorporating Fe 3+ ions with high dipole potential, was accumulated after intravenous injection in NCI-H460-luc2 large cell lung adenocarcinoma (homozygous KRAS p.Gln61His, c.183A > T and STK11 p.Gln37Ter, c.109C > T mutations and heterozygous PIK3CA p.Glu545Lys, c.1633G > A mutation) xenografts grown in BALB/c nude mice [ 45 ]. High intratumoral iron-dextran concentration served as a targeted thermosensitizer for mEHT-induced tumor destruction at the usual energy input.…”

Section: Combination With Chemotherapy and Cancer Thermo-sensitizamentioning

confidence: 99%

Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models

Krenács

Meggyesházi

Forika

et al. 2020

IJMS

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The benefits of high-fever range hyperthermia have been utilized in medicine from the Ancient Greek culture to the present day. Amplitude-modulated electro-hyperthermia, induced by a 13.56 MHz radiofrequency current (mEHT, or Oncothermia), has been an emerging means of delivering loco-regional clinical hyperthermia as a complementary of radiation-, chemo-, and molecular targeted oncotherapy. This unique treatment exploits the metabolic shift in cancer, resulting in elevated oxidative glycolysis (Warburg effect), ion concentration, and electric conductivity. These promote the enrichment of electric fields and induce heat (controlled at 42 °C), as well as ion fluxes and disequilibrium through tumor cell membrane channels. By now, accumulating preclinical studies using in vitro and in vivo models of different cancer types have revealed details of the mechanism and molecular background of the oncoreductive effects of mEHT monotherapy. These include the induction of DNA double-strand breaks, irreversible heath and cell stress, and programmed cells death; the upregulation of molecular chaperones and damage (DAMP) signaling, which may contribute to a secondary immunogenic tumor cell death. In combination therapies, mEHT proved to be a good chemosensitizer through increasing drug uptake and tumor reductive effects, as well as a good radiosensitizer by downregulating hypoxia-related target genes. Recently, immune stimulation or intratumoral antigen-presenting dendritic cell injection have been able to extend the impact of local mEHT into a systemic “abscopal” effect. The complex network of pathways emerging from the published mEHT experiments has not been overviewed and arranged yet into a framework to reveal links between the pieces of the “puzzle”. In this paper, we review the mEHT-related damage mechanisms published in tumor models, which may allow some geno-/phenotype treatment efficiency correlations to be exploited both in further research and for more rational clinical treatment planning when mEHT is involved in combination therapies.

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Section: Combination With Chemotherapy and Cancer Thermo-sensitizamentioning

confidence: 99%

Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models

Krenács

Meggyesházi

Forika

et al. 2020

IJMS

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“…Body temperature and weight measurement. The body temperatures of the Roborovski SH101 hamsters were measured by a high-precision thermal photographic method 52,53 . Each of the whole animal bodies was photo-graphed by FLIR thermal imaging camera, and the thermal images were analyzed by DirA program (FLIR Tools) to measure the body temperature.…”

Section: Methodsmentioning

confidence: 99%

Removal of Extracellular Vimentin in Blood Confers Resistance to Viral Infection

Kim

Wang

Kim

et al. 2022

Preprint

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The in vitro studies have repeatedly showed that extracellular vimentin (eVIM) promotes the penetration of viruses by acting as an adhesion factor, indicating that reduction of the eVIM density in the blood could be an effective approach to treat viral infections. However, despite its solid evidences, it has not been investigated previously whether circulating vimentin actually plays a pathogenic role during viral infections in vivo experiments. Here we provide in vivo evidence that eVIM plays a critical role during viral infections. Reduction of blood eVIM in the SARS-CoV-2-infected Roborovski SH101 hamster by i.v. injection of hzVSF-v13, a humanized anti-eVIM monoclonal antibody, treated COVID-19 by suppressing inflammation and viral replication. The overall therapeutic efficacy of hzVSF-v13 for COVID-19 was better than that of Remdesivir. We believe that this work provides an in vivo foundation for development of hzVSF-v13 as antiviral drugs to various other viral infections in addition to COVID-19.

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“…The body temperatures of the animals were measured by a high-precision thermal photographic method [ 24 , 25 ]. Each of the whole animal bodies was photographed by FLIR thermal imaging camera, and the thermal images were analyzed by DirA Program (FLIR Tools) to measure the body temperature.…”

Section: Methodsmentioning

confidence: 99%

Roborovski hamster (Phodopus roborovskii) strain SH101 as a systemic infection model of SARS-CoV-2

et al. 2021

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Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is currently causing a worldwide threat with its unusually high transmission rates and rapid evolution into diverse strains. Unlike typical respiratory viruses, SARS-CoV-2 frequently causes systemic infection by breaking the boundaries of the respiratory systems. The development of animal models recapitulating the clinical manifestations of COVID-19 is of utmost importance not only for the development of vaccines and antivirals but also for understanding the pathogenesis. However, there has not been developed an animal model for systemic infection of SARS-CoV-2 representing most aspects of the clinical manifestations of COVID-19 with systemic symptoms. Here we report that a Roborovski hamster strain SH101, a laboratory inbred hamster strain of P. roborovskii , displayed most symptoms of systemic infection upon SARS-CoV-2 infection as in the case of the human counterpart, unlike current COVID-19 animal models. Roborovski hamster strain SH101 post-infection of SARS-CoV-2 represented most clinical symptoms of COVID-19 such as snuffling, labored breathing, dyspnea, cough, hunched posture, progressive weight loss, ruffled fur, and high fever following shaking chills. Histological examinations also revealed initial right-predominated pneumonia as well as slight organ damages in the brain and liver, manifesting systemic COVID-19 cases. Considering the merit of a small animal as well as its clinical manifestations of SARS-CoV-2 infection in human, this hamster model seems to provide an ideal tool to investigate COVID-19.

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Iron-dextran as a thermosensitizer in radiofrequency hyperthermia for cancer treatment

Cited by 14 publications

References 21 publications

Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models

Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models

Removal of Extracellular Vimentin in Blood Confers Resistance to Viral Infection

Roborovski hamster (Phodopus roborovskii) strain SH101 as a systemic infection model of SARS-CoV-2

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