Iron detoxifying activity of ferritin

Cozzi, Anna; Santambrogio, Paolo; Levi, Sonia; Arosio, Paolo

doi:10.1016/0014-5793(90)80823-2

Cited by 77 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were obtained with human leukemia cells inundated with various types of oxidative stress 9). The possible mechanism underlying the anti-oxidative effects of ferritin is its capacity to bind to nitric oxide molecules,16) which have anti-oxidative properties, and to decrease lipid peroxidation by sequestering iron in solution 17)…”

Section: Discussionsupporting

confidence: 78%

Serum Ferritin Is Differentially Associated with Anti-oxidative Status and Insulin Resistance in Healthy Obese and Non-obese Women

et al. 2012

View full text Add to dashboard Cite

BackgroundFerritin is known to be associated with insulin resistance (IR) and oxidative stress; however, recent studies have shown that there is an association between ferritin and anti-oxidative status. To date, the biphasic response of ferritin to oxidative stress has not been fully evaluated. Thus, we investigated the association between ferritin and IR and anti-oxidative status in obese and non-obese women.MethodsWe evaluated the homeostasis model assessment of insulin resistance (HOMA-IR) and total anti-oxidant status (TAS) in a total of 111 healthy women between the ages of 32 and 68 years.ResultsIn all of the study subjects, ferritin levels were positively correlated with age (r = 0.38, P < 0.001), body mass index (r = 0.24, P = 0.01), TAS (r = 0.38, P < 0.001) and HOMA-IR (r = 0.20, P = 0.04). In the subgroup analysis, ferritin levels were correlated with age (r = 0.39, P < 0.001) and TAS (r = 0.43, P < 0.001) in the non-obese group and with insulin (r = 0.50, P = 0.02) and HOMA-IR (r = 0.52, P = 0.01) levels in the obese group. On stepwise multiple linear regression analysis, ferritin was found to be independently associated with TAS (B = 177.16, P < 0.0001) in the non-obese group and independently associated with HOMA-IR (B = 30.36, P = 0.01) in the obese group.ConclusionOur findings suggest ferritin is associated with IR in obese women and with anti-oxidative status in non-obese women. Further studies are warranted to elucidate the precise role of ferritin in obesity.

show abstract

Section: Discussionsupporting

confidence: 78%

Serum Ferritin Is Differentially Associated with Anti-oxidative Status and Insulin Resistance in Healthy Obese and Non-obese Women

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The rapid appearance of iron reaction product in our studies suggests that iron may accumulate before a postinsult response from the iron management proteins. This is important because the toxicity of iron will be inversely proportional to the availability of ferritin to sequester and detoxify ferrous iron (Cozzi et al, 1990), and directly proportional to the presence of hydrogen peroxide for Fenton chemistry to produce hydroxyl radicals (reviewed in Lesnefsky, 1994).…”

Section: Discussionmentioning

confidence: 99%

Changes in iron histochemistry after hypoxic-ischemic brain injury in the neonatal rat

et al. 1999

View full text Add to dashboard Cite

Iron can contribute to hypoxic-ischemic brain damage by catalyzing the formation of free radicals. The immature brain has high iron levels and limited antioxidant defenses. The objective of this study was to describe the early alterations in nonheme iron histochemistry following a hypoxic-ischemic (HI) insult to the brain of neonatal rats. We induced a HI insult to the right cerebral hemisphere in groups of 7-day-old rats. Rats were anesthetized, then their brains were perfused and fixed at 0, 1, 4, 8, 24 hr, and 1, 2, and 3 weeks of recovery. Forty-micron-thick frozen sections were stained for iron using the intensified Perls stain. Increased iron staining was first detected within the cytoplasm of cells with pyknotic nuclei at 4 hr of recovery. Staining increased rapidly over the first 24 hr in regions of ischemic injury. By 7 days recovery, reactive glia and cortical blood vessels also stained. Increased staining in gray matter persisted at 3 weeks of recovery, whereas white matter tracts had fewer iron-positive cells compared to normal. The early increase in iron staining could be caused by an accumulation of iron posthypoxicischemic injury or a change in iron from nonstainable heme iron to stainable nonheme iron. Regardless of the source, our results indicate that there is an increase in iron available to promote oxidant stress in the neonatal rat brain following hypoxia-ischemia.

show abstract

“…Enhanced proteolytic activity occurring in injured tissue also releases iron from storage proteins [117]. When non-protein-bound iron gains access to the extracellular space, its uptake by cells is enhanced by intracellular calcium and paradoxically also by increased levels of intracellular iron [118].…”

Section: Iron Toxicitymentioning

confidence: 99%

Free Radicals and Brain Damage in the Newborn

Buonocore

Perrone²,

Bracci³

2001

Neonatology

180

View full text Add to dashboard Cite

Newborns and particularly preterm infants are at high risk of oxidative stress and they are very susceptible to free radical oxidative damage. Indeed, there is evidence of an imbalance between antioxidant- and oxidant-generating systems which causes oxidative damage. The brain may be especially at risk of free radical-mediated injury because neuronal membranes are rich in polyunsaturated fatty acids and because the human newborn has a relative deficiency of brain superoxide dismutase and glutathione peroxidase. The brain of the term fetus is at higher risk of oxidative stress than that of the preterm fetus, as a consequence of its higher concentration of polyunsaturated fatty acids and the maturity of the N-methyl-D-aspartate receptor system at term. There seems to be a maturation-dependent window of vulnerability to free radical attack during oligodendrocyte development. Early in its differentiation, the oligodendrocyte may be vulnerable because of active acquisition of iron for differentiation at a time of relative delay in the development of certain key antioxidant defenses in the brain. Excess free iron and deficient iron-binding and -metabolizing capacity are additional features favoring oxidant stress in premature infants. Free radicals may be generated by different mechanisms, such as ischemia-reperfusion, neutrophil and macrophage activation, Fenton chemistry, endothelial cell xanthine oxidase, free fatty acid and prostaglandin metabolism and hypoxia. Reactive oxidant production by these different mechanisms contributes in a piecewise manner to the pathogenesis of perinatal brain injury.

show abstract

Iron detoxifying activity of ferritin

Cited by 77 publications

References 23 publications

Serum Ferritin Is Differentially Associated with Anti-oxidative Status and Insulin Resistance in Healthy Obese and Non-obese Women

Serum Ferritin Is Differentially Associated with Anti-oxidative Status and Insulin Resistance in Healthy Obese and Non-obese Women

Changes in iron histochemistry after hypoxic-ischemic brain injury in the neonatal rat

Free Radicals and Brain Damage in the Newborn

Contact Info

Product

Resources

About