Iron depletion: A defense against intracellular infection and neoplasia

Weinberg, Eugene D.

doi:10.1016/0024-3205(92)90279-x

Cited by 124 publications

(78 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have shown cellular Fe depletion as an effective host defense mechanism against pathogenic microorganisms and neoplasia [56], indicating a possible involvement for NK cell-derived CP in these processes. Increased levels of serum CP have been reported to occur in both human [57,58] and transgenic mice [59] hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 97%

Ceruloplasmin expression by human peripheral blood lymphocytes: A new link between immunity and iron metabolism

Banha

Marques

Palmeira‐de‐Oliveira

et al. 2008

Free Radical Biology and Medicine

View full text Add to dashboard Cite

Ceruloplasmin (CP) is a multicopper oxidase involved in the acute phase reaction to stress. Although the physiological role of CP is uncertain, its role in iron (Fe) homeostasis and protection against free radical-initiated cell injury has been widely documented. Previous studies showed the existence of two molecular isoforms of CP: secreted CP (sCP) and a membrane glycosylphosphatidylinositol (GPI)-anchored form of CP (GPI-CP). sCP is produced mainly by the liver and is abundant in human serum whereas GPI-CP is expressed in mammalian astrocytes, rat leptomeningeal cells, and Sertolli cells. Herein, we show using RT-PCR that human peripheral blood lymphocytes (huPBL) constitutively express the transcripts for both CP molecular isoforms previously reported. Also, expression of CP in huPBL is demonstrated by immunofluorescence with confocal microscopy and flow cytometry analysis using cells isolated from healthy blood donors with normal Fe status. Importantly, the results obtained show that natural killer cells have a significantly higher CP expression compared to all other major lymphocyte subsets. In this context, the involvement of lymphocyte-derived CP on host defense processes via its anti/prooxidant properties is proposed, giving further support for a close functional interaction between the immune system and the Fe metabolism.

show abstract

Section: Discussionmentioning

confidence: 97%

Ceruloplasmin expression by human peripheral blood lymphocytes: A new link between immunity and iron metabolism

Banha

Marques

Palmeira‐de‐Oliveira

et al. 2008

Free Radical Biology and Medicine

View full text Add to dashboard Cite

show abstract

“…alterations (increases as well as decreases) in cellular iron availability caused regulation of NOS transcription in J774 cells [539] . Macrophages and other host cells activated by IFN-γ can be induced to form a flavoprotein that converts L-arginine to NO + L-citrulline [548] . NO causes efflux of non-heme iron from infected host cells.…”

Section: T Gondii Infectionmentioning

confidence: 99%

“…Cellular depletion of the metal via either mechanism suppresses DNA synthesis as well as the functioning of aerobic respiratory enzymes. Macrophage regulation of growth of other host cells during embryogenesis, immune responses, or immunosurveillance might involve iron depletion [548] . Novel atherosclerotic markers indicating neutrophil activation represent Lf, an innate immune system protein with antiinflammatory and antioxidant properties [549,550] .…”

Section: T Gondii Infectionmentioning

confidence: 99%

Possible Pivotal Role of Latent Chronic T. gondii Infection in the Pathogenesis of Atherosclerosis

Prandota

2017

Journal of Cardiology and Therapy

View full text Add to dashboard Cite

“…106 As a nutrient that is essential for the survival of many microbes, increased iron availability promotes microbial growth. 107 In fact, the ability of a particular species of bacteria to glean iron from its host is often a good indicator of its virulence. It is logical then that the body sequesters iron in response to an infection.…”

Section: Markers Of Anemiamentioning

confidence: 99%

“…108 In iron-deficient conditions, blood plasma is moderately effective at inhibiting bacterial growth. 107,109,110 It has been our experience that both white and red blood cell counts surge and wane during therapy, tending to normalize as the inflammation resolves. Therefore, while it might otherwise seem reasonable for a clinician to directly manage ACD using iron supplements, doing so may actually lead to microbial proliferation.…”

Section: Markers Of Anemiamentioning

confidence: 99%

Immunostimulation in the era of the metagenome

Proal

Albert

Blaney³

et al. 2011

Cell Mol Immunol

View full text Add to dashboard Cite

Microbes are increasingly being implicated in autoimmune disease. This calls for a re-evaluation of how these chronic inflammatory illnesses are routinely treated. The standard of care for autoimmune disease remains the use of medications that slow the immune response, while treatments aimed at eradicating microbes seek the exact opposite-stimulation of the innate immune response. Immunostimulation is complicated by a cascade of sequelae, including exacerbated inflammation, which occurs in response to microbial death. Over the past 8 years, we have collaborated with American and international clinical professionals to research a model-based treatment for inflammatory disease. This intervention, designed to stimulate the innate immune response, has required a reevaluation of disease progression and amelioration. Paramount is the inherent conflict between palliation and microbicidal efficacy. Increased microbicidal activity was experienced as immunopathology-a temporary worsening of symptoms. Further studies are needed, but they will require careful planning to manage this immunopathology.

show abstract

Iron depletion: A defense against intracellular infection and neoplasia

Cited by 124 publications

References 57 publications

Ceruloplasmin expression by human peripheral blood lymphocytes: A new link between immunity and iron metabolism

Ceruloplasmin expression by human peripheral blood lymphocytes: A new link between immunity and iron metabolism

Possible Pivotal Role of Latent Chronic T. gondii Infection in the Pathogenesis of Atherosclerosis

Immunostimulation in the era of the metagenome

Contact Info

Product

Resources

About