Iron deficiency, still a rarity in children with sickle cell anemia in Ile-Ife, Nigeria

Odunlade, O.C.; Adeodu, O O; Owa, Joshua A.; Obuotor, Efere Martins

doi:10.1016/j.htct.2018.11.006

Cited by 7 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean MCV, MCH and MCHC, which are the markers of iron status, were all within normal ranges [ 20 ]. This finding is similar to other reports [ 7 , 21 , 22 ]. The normal iron markers in children with SCA may be attributed to increased red cell turnover and repeated blood transfusion.…”

Section: Discussionsupporting

confidence: 93%

Haematological Profile of Children With Sickle Cell Anaemia in Steady State

Aliu

Jalo

Quadri

et al. 2020

Cureus

View full text Add to dashboard Cite

Introduction Sickle cell anaemia (SCA) is an inherited, autosomal recessive condition that results from a mutation in the β-globin gene. Vascular occlusion is the underlying mechanism behind a myriad of complications encountered. This vascular occlusion is primarily caused by the increased tendency of red blood cells (RBC) to adhere to the vascular endothelium, and the activation of platelets and total leucocyte count (TLC), hence the need for a steady-state haematological profile in these patients. Method This was a cross-sectional study conducted over four months at a sickle cell clinic. Haemoglobin (Hb) concentration, haematocrit, platelet, TLC, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) of the subjects were recorded and analysed. Results Ninety-nine subjects aged 1-18 years were recruited for the study. There were 53 (53.5%) males. Leucocytosis was seen in 80 (80.8%), anaemia in 99 (100%), and thrombocytosis in 30 (30.3%) patients. The mean Hb, TLC and platelets were 7.9 ± 1.3g/dl, 14.3 ± 4.5 x 10 3 /mm 3 and 391.5 ± 182.6 x 10 3 /mm 3 respectively. Mean MCV, MCH and MCHC were 81.3 ± 7.1 fl, 28.6 ± 2.9 pg and 35.2 ± 1.7 g/dl respectively. Children aged one to four years had the highest TLC (p=0.002) but the lowest mean Hb and platelet (p=0.094 and 0.06) respectively. The mean MCV, MCH and MCHC were lowest in children aged one to four years (p=0.047, 0.001 and 0.001). Conclusion Anaemia, leucocytosis and thrombocytosis are characteristics features of children with SCA, especially in male and younger subjects. Although Iron markers are generally normal in children with SCA, those under the age of five years tend to have lower values.

show abstract

Section: Discussionsupporting

confidence: 93%

Haematological Profile of Children With Sickle Cell Anaemia in Steady State

Aliu

Jalo

Quadri

et al. 2020

Cureus

View full text Add to dashboard Cite

show abstract

“…However, it should be mentioned that the majority of enrolled patients had normal MCV and MCH values. This observation is indeed supported by the observation of previous authors who found that most of patients with sickle cell disease had normal MCV, MCH and even MCHC values [19,21,22]. These indices reflect normal iron status, which is the result of increased red cell turn-over and blood transfusion in patients with sickle cell disease.…”

Section: Discussionsupporting

confidence: 85%

Hematological Characteristics of a Sample of Iraqi Patients with Sickle Cell Anemia and Their Correlation with Age and Gender

Meshay¹,

Khamees²,

Wadaha³

2022

DJM

View full text Add to dashboard Cite

Background: Characterization of hematological parameters in patients with sickle cell anemia can direct treatment goals toward strategies reducing morbidity and mortality rate.Objective: To evaluate the hematological parameters in a subset of Iraqi patients with sickle cell anemia in relation to age and gender. Patients and Methods: This cross-sectional study was included 30 patients with sickle cell anemia who were known to be at a steady clinical state with no vaso-occlusive crises. About 5 ml of venous blood was collected in EDTA tube from each participant. The complete blood count was conducted according to standard protocol. Results: The mean age was 7.93 ±2.43 years and the age range was 4 to 12 years. The study included 17 males and 13 females. 29 (96.7 %) were anemic and there was no significant difference in mean hemoglobin levels between males and females (p = 0.838). Males demonstrated higher frequency of low mean cell volume (MCV) and mean cell hemoglobin (MCH) (64.7% and 58.8%, respectively) than females (7.7% and 7.7%, respectively) with highly significant differences. Conclusion: Some hematological parameters in patients with sickle disease are affected by gender but show no significant correlation to age. Keywords: Hematological characteristics, Sickle cell anemia, Iraq

show abstract

“…Sickle cell children in this study despite the anaemia had a normal Ferritin level, going on the same line with the findings of Odunlade et al in Nigeria [17] concluding that despite the anaemic status of sickle cell patients, their Ferritin level is usually normal or high.…”

Section: Anaemia Inflammation and Leucocytosissupporting

confidence: 91%

Factors Affecting Ferritin Level in Children of 6 to 59 Months in the Eastern Region of Cameroon

Agokeng

Tayou

Assob

et al. 2019

IBRR

View full text Add to dashboard Cite

Aim: Ferritin reflects total iron storage and is also the first laboratory index to decline with iron deficiency. It may be less accurate in children with infectious or inﬂammatory conditions as an acute phase reactant. Considering the fact that Cameroonian children live in malaria endemic and high risk hookworm infection area, our objective was to study factors affecting Ferritin level including socio-demographic data, child nutrition, anaemia and inflammatory status. Study Design: A case control study was carried out with anaemic children as cases and non-anaemic as controls. Place and Duration: Paediatric and laboratory units of the Bertoua regional Hospital, from November 2018 to January 2019. Methodology: A case control study was carried out in children of 6 to 59 months attending the Bertoua regional hospital. Data were collected and blood distributed in EDTA and dry tubes for full blood count, C - reactive protein (CRP) and Ferritin analysis. Obtained data were analysed with SPSS 21.0 using Pearson’s Chi Square test. Results: 126 children were included, 63 anaemic (Haemoglobin<11 g/dL) as cases and 63 non anaemic as controls. The Mean age of children was 27.3+/- 15.4 months, the mean haemoglobin was 10.4+/- 1.6 g/dL. Ferritin as state by WHO for the diagnosis of iron deficiency anaemia, was below 30 μg/L in 3.2% independently of anaemic status. Inflammation tested by CRP occurred in 37.3% of children. When the ferritin cut-off value was shifted to 50 μg/L, Ferritin was low in 9.5% thus approaching the stated frequency of iron deficiency obtained recentlyin Cameroon. Mean Ferritin level was 346.5 μg/L. Conclusion: The relatively high level of Ferritin showed that iron storage seems to remain intact in most children despite anaemic or inflammatory status. The level of Ferritin in children is highly dependent on haem iron consumption and food diversification also has a role to play.

show abstract

Iron deficiency, still a rarity in children with sickle cell anemia in Ile-Ife, Nigeria

Cited by 7 publications

References 23 publications

Haematological Profile of Children With Sickle Cell Anaemia in Steady State

Haematological Profile of Children With Sickle Cell Anaemia in Steady State

Hematological Characteristics of a Sample of Iraqi Patients with Sickle Cell Anemia and Their Correlation with Age and Gender

Factors Affecting Ferritin Level in Children of 6 to 59 Months in the Eastern Region of Cameroon

Contact Info

Product

Resources

About