Iron deficiency protects inbred mice against infection with Plasmodium chabaudi

Harvey, Philip W.; Bell, Rudolph M.; Nesheim, M. C.

doi:10.1128/iai.50.3.932-934.1985

Cited by 38 publications

(10 citation statements)

References 12 publications

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“…C57BL/6 mice (female, aged 5 wk) were obtained from Kyudo (Tosu, Japan) and BALB/c nu/nu (nude) mice from CLEA (Japan). IDA mice were bred as described elsewhere 32. Briefly, C57BL/6 mice, or nude mice, were fed either a control or iron‐deficient diet for 10 wk.…”

Section: Methodsmentioning

confidence: 99%

A critical role for phagocytosis in resistance to malaria in iron‐deficient mice

Matsuzaki-Moriya

Ishida

et al. 2011

Eur J Immunol

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JapanBoth iron-deficient anemia (IDA) and malaria remain a threat to children in developing countries. Children with IDA are resistant to malaria, but the reasons for this are unknown. In this study, we addressed the mechanisms underlying the protection against malaria observed in IDA individuals using a rodent malaria parasite, Plasmodium yoelii (Py). We showed that the intra-erythrocytic proliferation and amplification of Py parasites were not suppressed in IDA erythrocytes and immune responses specific for Py parasites were not enhanced in IDA mice. We also found that parasitized IDA cells were more susceptible to engulfment by phagocytes in vitro than control cells, resulting in rapid clearance of parasitized cells and that protection of IDA mice from malaria was abrogated by inhibiting phagocytosis. One possible reason for this rapid clearance might be increased exposure of phosphatidylserine at the outer leaflet of parasitized IDA erythrocytes. The results of this study suggest that parasitized IDA erythrocytes are eliminated by phagocytic cells, which sense alterations in the membrane structure of parasitized IDA erythrocytes.

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Section: Methodsmentioning

confidence: 99%

A critical role for phagocytosis in resistance to malaria in iron‐deficient mice

Matsuzaki-Moriya

Ishida

et al. 2011

Eur J Immunol

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“…When the iron-deficient mice were then fed iron-sufficient foods, they fell victim to recrudescent parasitemia. 48 More recent experimental evidence refutes the earlier nutritional immunity hypothesis and concludes no significant protection of iron deficiency in young rats. 49 Other evidence suggests that iron deficiency impairs immune responses, including T lymphocyte production and activity, natural killer cell activity, and neutrophil function.…”

Section: Introductionmentioning

confidence: 80%

Undernutrition as an Underlying Cause of Malaria Morbidity and Mortality in Children Less Than Five Years Old

Caulfield¹,

Richard²,

Black³

2004

The American Journal of Tropical Medicine and Hygiene

239

178

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Undernutrition is highly prevalent in many areas in which morbidity and mortality from malaria is unacceptably high. That undernutrition exacerbates diarrhea and respiratory infections is widely demonstrated; however, research suggests that it may exacerbate, palliate, or have little effect on malaria outcomes. This review examines the global burden of malaria associated with various nutrient deficiencies as well as underweight status in children 0-4 years of age. Although the association is complex and requires additional research, improved nutritional status lessens the severity of malaria episodes and results in fewer deaths due to malaria. Deficiencies in vitamin A, zinc, iron, folate, as well as other micronutrients are responsible for a substantial proportion of malaria morbidity and mortality. It is recommended that nutrition programs be integrated into existing malaria intervention programs.

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“…Multiple studies have attempted to evaluate the benefit of iron supplementation in malaria-endemic areas [19,[115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130][131][132][133][134]. Some studies reported that iron supplementation increased the risk of developing or reactivating malarial illness [19,115,118], while others reported no significant adverse effects [123,125,135]. Experiments with rodent malaria have also yielded conflicting results [135][136][137][138].…”

Section: Ironmentioning

confidence: 99%

“…Some studies reported that iron supplementation increased the risk of developing or reactivating malarial illness [19,115,118], while others reported no significant adverse effects [123,125,135]. Experiments with rodent malaria have also yielded conflicting results [135][136][137][138]. To clarify this issue, a systematic review and meta-analysis of placebo-controlled trials of iron supplemen-tation in humans was recently completed [139].…”

Section: Ironmentioning

confidence: 99%

Nutritional Modulation of Malaria Morbidity and Mortality

2000

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This review critically examines the relationship between nutritional status and malaria. The data indicate that protein-energy malnutrition is associated with greater malaria morbidity and mortality in humans. In addition, controlled trials of either vitamin A or zinc supplementation show that these nutrients can substantially reduce clinical malaria attacks. Data for iron indicate that supplementation may minimally aggravate certain malariometric indices in some settings and also strongly improve hematologic status. Withholding of iron supplements from deficient population is, therefore, not currently indicated. Available evidence for other nutrients describe varied effects, with some deficiencies being exacerbative (e.g., thiamine), protective (e.g., vitamin E), or both exacerbative and protective in different settings (e.g., riboflavin, vitamin C). The roles of folate, other B vitamins, unsaturated fatty acids, amino acids, and selenium are also examined. Study of the interactions between nutrition and malaria may provide insight to protective mechanisms and result in nutrient-based interventions as low-cost and effective adjuncts to current methods of malaria prevention and treatment.

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Iron deficiency protects inbred mice against infection with Plasmodium chabaudi

Cited by 38 publications

References 12 publications

A critical role for phagocytosis in resistance to malaria in iron‐deficient mice

A critical role for phagocytosis in resistance to malaria in iron‐deficient mice

Undernutrition as an Underlying Cause of Malaria Morbidity and Mortality in Children Less Than Five Years Old

Nutritional Modulation of Malaria Morbidity and Mortality

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