Iron Deficiency Modulates Metabolic Landscape of
            <i>Bacteroidetes</i>
            Promoting Its Resilience during Inflammation

Lewis, Janina P.; Gui, Qin

doi:10.1128/spectrum.04733-22

Cited by 2 publications

(1 citation statement)

References 64 publications

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“…Nevertheless, comparative genomic analyses have shown that some gut commensals are also equipped (superoxide dismutases or reductases, PerR, rubrerythrins.) 53 , 54 , and measurements of antioxidative potential among Bifidobacteriaceae and lactic acid bacteria have revealed the ability of certain strains to inhibit lipoperoxidation in vivo and in vitro using liposomal suspensions 55 .…”

Section: Discussionmentioning

confidence: 99%

Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in male rats

Olier,

Naud,

Fouché

et al. 2024

npj Sci Food

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The haemoglobin content in meat is consistently associated with an increased risk of colorectal cancer, whereas calcium may play a role as a chemopreventive agent. Using rodent models, calcium salts have been shown to prevent the promotion of haem-induced and red meat-induced colorectal carcinogenesis by limiting the bioavailability of the gut luminal haem iron. Therefore, this study aimed to compare impacts of dietary calcium provided as calcium salts or dairy matrix on gut homoeostasis perturbations by high haeminic or non-haeminic iron intakes. A 3-week intervention study was conducted using Fischer 344 rats. Compared to the ferric citrate-enriched diet, the haemoglobin-enriched diet led to increased faecal, mucosal, and urinary lipoperoxidation-related biomarkers, resulting from higher gut luminal haem iron bioavailability. This redox imbalance was associated to a dysbiosis of faecal microbiota. The addition of calcium to haemoglobin-enriched diets limited haem iron bioavailability and counteracted redox imbalance, with improved preventive efficacy when calcium was provided in dairy matrix. Data integration revealed correlations between haem-induced lipoperoxidation products and bacterial communities belonging to Peptococcaceae, Eubacterium coprostanoligenes group, and Bifidobacteriaceae. This integrated approach provides evidence of the benefits of dairy matrix as a dietary calcium vehicle to counteract the deleterious side-effects of meat consumption.

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Section: Discussionmentioning

confidence: 99%

Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in male rats

Olier,

Naud,

Fouché

et al. 2024

npj Sci Food

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Oral and Intestinal Bacterial Flora in Patients with Increased Periodontal Inflamed Surface Area: A Cross-Sectional Study

Taniguchi,

Aoyama,

Fujii

et al. 2024

JCM

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Background/Objectives: Periodontitis is caused by bacterial plaque. The oral microflora may interact with the intestinal microflora and play a role in the development of periodontitis. The periodontal inflamed surface area (PISA) has been shown to be a useful indicator of periodontal disease related to systemic diseases; however, few studies have shown an association between PISA and the bacterial flora. This study aimed to determine the association between PISA and oral and intestinal bacteria. Methods: Participants were recruited between 2018 and 2021 at the Medical and Dental Collaboration Center of Kanagawa Dental University Hospital. A periodontal clinical examination was performed, and the PISA was calculated. Salivary tests were conducted, and leukocyte scores in the saliva were calculated. Moreover, 16S rRNA amplicon sequencing was performed using saliva and stool samples to analyze oral and intestinal bacteria, respectively. Results: Higher PISA levels resulted in an increased presence of Bacteroides and a decreased presence of Proteobacteria and Actinobacteria in the saliva. An increase in Bacteroides was detected in the saliva of patients with high leukocyte scores. No correlation was observed between PISA and intestinal bacteria. Conclusions: Bacteroides was highly abundant in the saliva of patients with worsened periodontal conditions, as indicated by PISA. No association was found between PISA and intestinal bacteria.

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Iron Deficiency Modulates Metabolic Landscape of Bacteroidetes Promoting Its Resilience during Inflammation

Abstract: Bacteroidetes are an important group of anaerobic bacteria abundant both in the oral and gut microbiomes. Although iron is a required nutrient for most living organisms, the molecular mechanisms of adaptation to the changing levels of iron are not well known in this group of bacteria.

Cited by 2 publications

References 64 publications

Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in male rats

Calcium-rich dairy matrix protects better than mineral calcium against colonic luminal haem-induced alterations in male rats

Oral and Intestinal Bacterial Flora in Patients with Increased Periodontal Inflamed Surface Area: A Cross-Sectional Study

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