Iron Deficiency in Women’s Health: New Insights into Diagnosis and Treatment

Moisidis-Tesch, Christina; Shulman, L.P.

doi:10.1007/s12325-022-02157-7

Cited by 6 publications

(5 citation statements)

References 42 publications

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“…Oral iron is notoriously poorly tolerated by pregnant women and thus compliance is often an issue 49 . Moreover, even if compliance is good, there is concern about whether oral iron treatment during pregnancy is efficacious with respect to fetal iron loading.…”

Section: Fetal Iron Accretion and Risk Factors For Reduced Fetal Iron...mentioning

confidence: 99%

“…53 Oral iron is notoriously poorly tolerated by pregnant women and thus compliance is often an issue. 49 Moreover, even if compliance is good, there is concern about whether oral iron treatment during pregnancy is efficacious with respect to fetal iron loading. For example, a study of daily oral iron, initiated at or prior to 20 weeks' gestation and continued until delivery, showed an improvement of iron parameters.…”

Section: Maternal Intervention Options and Their Relations To Infant ...mentioning

confidence: 99%

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Maternal gestational iron status and infant haematological and neurodevelopmental outcomes

Georgieff

2023

BJOG

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Prevention of iron deficiency (ID), the most common micronutrient deficiency in infants and children, begins prenatally by ensuring adequate fetal loading. Adequate intrauterine iron status is crucial for normal fetal brain development, postnatal brain performance and prevention of early postnatal iron deficiency, particularly in infants fed exclusively human milk. Adequate fetal loading may be achieved in some cases through adequate maternal iron levels prior to pregnancy and oral iron supplementation during pregnancy. However, because so many women are iron‐deficient leading up to pregnancy, coupled with the negative iron balance induced by pregnancy, a large number of women remain iron‐deficient during pregnancy. More consistent iron‐specific early screening and more effective iron delivery approaches are needed to solve this global problem.

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Section: Fetal Iron Accretion and Risk Factors For Reduced Fetal Iron...mentioning

confidence: 99%

Section: Maternal Intervention Options and Their Relations To Infant ...mentioning

confidence: 99%

Maternal gestational iron status and infant haematological and neurodevelopmental outcomes

Georgieff

2023

BJOG

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“…Young women stand apart as the most disadvantaged population due to the bleeding-related physiological iron losses during menstruation and labor, in addition to repeated pregnancies and lactation that increase iron demand [ 35 ]. The availability of medical care is a critical socioeconomic factor in preventing excessive blood loss during menarche, pregnancy, and labor by adequate timing of the umbilical cord clamping [ 36 , 37 ].…”

Section: Disparities In India: Relevance Of Ida Risk Factorsmentioning

confidence: 99%

Iron Deficiency Anemia: Efficacy and Limitations of Nutritional and Comprehensive Mitigation Strategies

et al. 2022

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Iron deficiency anemia (IDA) has reached epidemic proportions in developing countries and has become a major global public health problem, affecting mainly 0–5-year-old children and young women of childbearing age, especially during pregnancy. Iron deficiency can lead to life-threatening loss of red blood cells, muscle function, and energy production. Therefore, the pathogenic features associated with IDA are weakness and impaired growth, motor, and cognitive performance. IDA affects the well-being of the young generation and the economic advancement of developing countries, such as India. The imbalance between iron intake/absorption/storage and iron utilization/loss culminates into IDA. However, numerous strategic programs aimed to increase iron intake have shown that improvement of iron intake alone has not been sufficient to mitigate IDA. Emerging critical risk factors for IDA include a composition of cultural diets, infections, genetics, inflammatory conditions, metabolic diseases, dysbiosis, and socioeconomic parameters. In this review, we discuss numerous IDA mitigation programs in India and their limitations. The new multifactorial mechanism of IDA pathogenesis opens perspectives for the improvement of mitigation programs and relief of IDA in India and worldwide.

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“…Studies propose that CD may interfere with the normal mineralization of dental enamel, resulting in structural abnormalities [ 16 ]. Enamel defects, such as pitting, grooving, and discoloration, have been reported in individuals with CD, providing potential oral markers for the condition [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

Celiac Disease-Related Enamel Defects: A Systematic Review

Inchingolo,

Dipalma,

Viapiano

et al. 2024

JCM

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Introduction: This systematic review aims to elucidate the intricate correlation between celiac disease (CD) and dental enamel defects (DED), exploring pathophysiological mechanisms, oral health implications, and a dentist’s role in early diagnosis. Materials and methods: Following PRISMA guidelines, a comprehensive search from 1 January 2013 to 1 January 2024 across PubMed, Cochrane Library, Scopus, and Web of Science identified 153 publications. After exclusions, 18 studies met the inclusion criteria for qualitative analysis. Inclusion criteria involved study types (RCTs, RCCTs, case series), human participants, English language, and full-text available. Results: The search yielded 153 publications, with 18 studies meeting the inclusion criteria for qualitative analysis. Notable findings include a high prevalence of DED in CD patients, ranging from 50 to 94.1%. Symmetrical and chronological defects, according to Aine’s classification, were predominant, and significant associations were observed between CD severity and enamel defect extent. Conclusions: The early recognition of oral lesions, particularly through Aine’s classification, may signal potential CD even in the absence of gastrointestinal symptoms. Correlations between CD and dental health conditions like molar incisor hypomineralization (MIH) emphasize the dentist’s crucial role in early diagnosis. Collaboration between dentists and gastroenterologists is essential for effective monitoring and management. This review consolidates current knowledge, laying the groundwork for future research and promoting interdisciplinary collaboration for improved CD-related oral health outcomes. Further large-scale prospective research is recommended to deepen our understanding of these issues.

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Iron Deficiency in Women’s Health: New Insights into Diagnosis and Treatment

Cited by 6 publications

References 42 publications

Maternal gestational iron status and infant haematological and neurodevelopmental outcomes

Maternal gestational iron status and infant haematological and neurodevelopmental outcomes

Iron Deficiency Anemia: Efficacy and Limitations of Nutritional and Comprehensive Mitigation Strategies

Celiac Disease-Related Enamel Defects: A Systematic Review

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