Iron deficiency in preschool children with autistic spectrum disorders

Bi̇lgi̇ç, Ayhan; Gürkan, Kağan; Türkoğlu, Serhat; Akça, Ömer Faruk; Kılıç, Birim Günay; Uslu, Runa

doi:10.1016/j.rasd.2009.12.008

Cited by 33 publications

(54 citation statements)

References 28 publications

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“…Our findings confirmed that iron deficiency and anemia are common in autism, in parallel with previous reports [4,8,20]. In the literature, there are three studies investigating iron status in children with autism.…”

Section: Discussionsupporting

confidence: 92%

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Ferritin and iron levels in children with autistic disorder

et al. 2011

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Section: Discussionsupporting

confidence: 92%

“…High prevalence of iron deficiency has also been reported in children with autism spectrum disorders [4,8,20]. Inadequate dietary iron intake was considered as a cause of iron deficiency, and low iron intake was thought to be associated with food selectivity which is commonly seen in children with autistic disorder (AD) [5,13,14,24].…”

Section: Introductionmentioning

confidence: 99%

Ferritin and iron levels in children with autistic disorder

et al. 2011

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“…It is highly probable that a well-balanced diet plays an essential role in development and maintenance of brain functions, because good nutrition is a cornerstone of good health, whereas poor nutrition is associated with reduced immunity, impaired physical development, and reduced productivity (World Health Organization, 2016). Children with ASD often have restricted diets that can lead to nutrient deficiencies with brain metal homeostasis disturbances (Bilgiç et al, 2010;Sidrak et al, 2014). Iron deficiency is one of the most prevalent types of malnutrition, affecting probable two billion people in the world, and pregnant women and young children are affected most severely, because pregnancy and infant growth demand iron (World Health Organization, 2016).…”

Section: Asd and Neuroinflammationmentioning

confidence: 99%

“…In the brain, iron is transported by transferrin or divalent metal transporter-1 from the peripheral blood and is essential for the activity of several enzymes involved in myelination process and monoamine neurotransmitter synthesis (Dusek et al, 2015). Iron deficiency is suggested to be related to development of ASD (Bilgiç et al, 2010;Sidrak et al, 2014). Lower iron concentrations in the blood appear to induce transport of neurotoxic manganese at ASPET Journals on May 9, 2018 jpet.aspetjournals.org…”

Section: Asd and Neuroinflammationmentioning

confidence: 99%

Involvement of Neuroinflammation during Brain Development in Social Cognitive Deficits in Autism Spectrum Disorder and Schizophrenia

Nakagawa¹,

Chiba²

2016

Journal of Pharmacology and Experimental Therapeutics

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Development of social cognition, a unique and high-order function, depends on brain maturation from childhood to adulthood in humans. Autism spectrum disorder (ASD) and schizophrenia have similar social cognitive deficits, although age of onset in each disorder is different. Pathogenesis of these disorders is complex and contains several features, including genetic risk factors, environmental risk factors, and sites of abnormalities in the brain. Although several hypotheses have been postulated, they seem to be insufficient to explain how brain alterations associated with symptoms in these disorders develop at distinct developmental stages. Development of ASD appears to be related to cerebellar dysfunction and subsequent thalamic hyperactivation in early childhood. By contrast, schizophrenia seems to be triggered by thalamic hyperactivation in late adolescence, whereas hippocampal aberration has been possibly initiated in childhood. One of the possible culprits is metal homeostasis disturbances that can induce dysfunction of blood-cerebrospinal fluid barrier. Thalamic hyperactivation is thought to be induced by microglia-mediated neuroinflammation and abnormalities of intracerebral environment. Consequently, it is likely that the thalamic hyperactivation triggers dysregulation of the dorsolateral prefrontal cortex for lower brain regions related to social cognition. In this review, we summarize the brain aberration in ASD and schizophrenia and provide a possible mechanism underlying social cognitive deficits in these disorders based on their distinct ages of onset.

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“…Many of other studies looked into social, psychological, behavioural and biochemical aspects of ASD in Turkish children [30][31][32][33][34]. Since ASD is more common in males than females, this study attempted investigating the dietary intake of Turkish male adolescents aged 12-18 years and having a normal to high body mass index (BMI) for-age.…”

Section: Introductionmentioning

confidence: 99%

Dietary intake of adolescents with Autism Spectrum Disorder (ASD) and normal to High Body Mass Index (BMI)

Bicer¹,

Alsaffar²

2016

Integr Food Nutr Metab

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Dietary intake of 117 male adolescents (aged 12 to 18 years, residing in Istanbul, Turkey) with autism spectrum disorder (ASD) and classified as normal (n=39), overweight (n=39) and obese (n=39) according to BMI-for-age were assessed. Anthropometric measurements were taken and participants were asked to complete a general questionnaire, feeding assessment survey and three-day food records. Daily intakes of energy and nutrients were calculated using food records. The EAR-cut point method was used to investigate the prevalence of inadequacy and potential risk of excess. Dietary fibre, calcium, zinc and folate intake of many participants were below the DRI value. Prevalence of inadequacy for iron, vitamin A, B6 and C were lower than these nutrients. Daily consumption of sodium and cholesterol was higher than the recommendations. Percent DRI value for energy differed significantly in each BMI-for-age group (p<0.05) and was highest in the obese category. This category also had higher %DRI values for most vitamins and minerals. Percent energy values provided by macronutrients (AMDR) were not significantly different from each other across BMI-for-age categories and remained within the reference values.

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Iron deficiency in preschool children with autistic spectrum disorders

Cited by 33 publications

References 28 publications

Ferritin and iron levels in children with autistic disorder

Ferritin and iron levels in children with autistic disorder

Involvement of Neuroinflammation during Brain Development in Social Cognitive Deficits in Autism Spectrum Disorder and Schizophrenia

Dietary intake of adolescents with Autism Spectrum Disorder (ASD) and normal to High Body Mass Index (BMI)

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