Piglets, especially for weaning piglets, due to rapid growth, physiological immaturity and gradual reduction of maternal antibodies, showed a lower immunity level and higher morbidity, which affects seriously growth performance and economic benefits. It is important that the piglets are how to adapt to nutrient digestion and absorption, and to develop the intestinal function and the colonization of gut microbiota during early stage as soon as possible. Lactoferrin is a natural glycoprotein polypeptide that is differentiated from the transferrin family. It is widely found in mucosal secretions such as saliva and tears, and most highly in milk and colostrum. As a multifunctional bioactive protein and a recommended food additive, lactoferrin is a potential candidate of alternatives to antibiotics and health promoter additive in piglet nutrition and production,it is expected that lactoferrin as green additive would play its important role for health maintaining in pig production. The following actual effects would be reviewed and evaluated: improvement on the digestion and absorption capacity in intestinal tracts, promotion on iron supplementation and reduction of the incidence of iron deficiency anemia, regulation on intestinal function and microbial flora balance, and enhancement on the disease resistance of piglets as an immunomodulatory and enhancer.