Iron deficiency in children with global developmental delay and autism spectrum disorder

Sidrak, Samuel; Yoong, Terence; Woolfenden, Susan

doi:10.1111/jpc.12483

Cited by 48 publications

(37 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[77] Interestingly, iron deficiency and iron deficiency anemia have been observed to be more common in children with global developmental delay and/or ASD than in the general population. [78] A connection between low serum ferritin and sleep disturbance in children with ASD was also suggested based on a treatment trial showing that for a majority of children with ASD and restless sleep, iron therapy was effective at improving sleep. [79]…”

Section: Overlapping Mechanisms Between Sleep and Asdmentioning

confidence: 99%

Sleep in Autism Spectrum Disorders

Veatch

Maxwell-Horn

Malow

2015

Curr Sleep Medicine Rep

View full text Add to dashboard Cite

Autism spectrum disorders (ASD) are common neurodevelopmental conditions, affecting 1 in 68 children. Sleep disturbance, particularly insomnia, is very common in children diagnosed with ASD, with evidence supporting overlapping neurobiological and genetic underpinnings. Disturbed sleep exacerbates core and related ASD symptoms and has a substantial negative impact on the entire family. Treatment of sleep disturbance holds promise for ameliorating many of the challenging behavioral symptoms that children with ASD and their families face. Behavioral and pharmacological studies indicate promising approaches to treating sleep disturbances in this population. Awareness of treatment options is particularly important as parents and clinicians may believe that sleep disturbance is part of autism and refractory to therapy. In addition, autism symptoms refractory to treatment with conventional psychiatric medications may improve when sleep is addressed. Additional evidence-based studies are needed, including those that address the underlying biology of this condition.

show abstract

Section: Overlapping Mechanisms Between Sleep and Asdmentioning

confidence: 99%

Sleep in Autism Spectrum Disorders

Veatch

Maxwell-Horn

Malow

2015

Curr Sleep Medicine Rep

View full text Add to dashboard Cite

show abstract

“…Breastfed infants of normal birth weight under the age of 6 months have a low prevalence of IDA and do not require iron supplementation; however iron supplements of 1-3 mg per day are thought to improve neurodevelopment for low birth weight infants less than 6 months [3]. For formula-fed infants under the age of six months, ironfortified formula prevents IDA and may improve neurodevelopment [4].…”

Section: Introductionmentioning

confidence: 99%

Iron Status of Infants and Toddlers Age 6 to 18 Months and Association with Type of Milk Consumed from DNSIYC Secondary Analysis

Alghamdi¹

2017

J Nutr Food Sci

View full text Add to dashboard Cite

This study compares the intake of different types of milk, iron, haem iron, non-haem iron, and Vitamin C intake among infant and children age 6-18 months of age from Diet and Nutrition Survey of Infants and Young Children (DNSIYC). Approach SACN 2010 recommendation, the Reference Nutrient Intakes (RNI) of iron and Vitamin C for infant and children age 6-18 months was investigated in this study. Moreover, Ferritin and haemoglobin investigated as well to assess iron status, subjects who donated bloods were included in this study to investigate their iron status, 473 subjects for haemoglobin, and 443 for ferritin. Different factors investigated on 2567 subjects, include age groups, sex, ethnicity, socioeconomic level, maternal education level, and different types of milk consumed. This study found significant difference for ferritin and haemoglobin in different levels, across different types of milk consumed, haemiron, Vitamin C, age groups and maternal education level. While there were no significant differences across sex, ethnicity and socioeconomic level in all age groups.

show abstract

“…In the brain, iron is transported by transferrin or divalent metal transporter-1 from the peripheral blood and is essential for the activity of several enzymes involved in myelination process and monoamine neurotransmitter synthesis (Dusek et al, 2015). Iron deficiency is suggested to be related to development of ASD (Bilgiç et al, 2010;Sidrak et al, 2014). Lower iron concentrations in the blood appear to induce transport of neurotoxic manganese at ASPET Journals on May 9, 2018 jpet.aspetjournals.org…”

Section: Asd and Neuroinflammationmentioning

confidence: 99%

“…It is highly probable that a well-balanced diet plays an essential role in development and maintenance of brain functions, because good nutrition is a cornerstone of good health, whereas poor nutrition is associated with reduced immunity, impaired physical development, and reduced productivity (World Health Organization, 2016). Children with ASD often have restricted diets that can lead to nutrient deficiencies with brain metal homeostasis disturbances (Bilgiç et al, 2010;Sidrak et al, 2014). Iron deficiency is one of the most prevalent types of malnutrition, affecting probable two billion people in the world, and pregnant women and young children are affected most severely, because pregnancy and infant growth demand iron (World Health Organization, 2016).…”

Section: Asd and Neuroinflammationmentioning

confidence: 99%

Involvement of Neuroinflammation during Brain Development in Social Cognitive Deficits in Autism Spectrum Disorder and Schizophrenia

Nakagawa¹,

Chiba²

2016

Journal of Pharmacology and Experimental Therapeutics

View full text Add to dashboard Cite

Development of social cognition, a unique and high-order function, depends on brain maturation from childhood to adulthood in humans. Autism spectrum disorder (ASD) and schizophrenia have similar social cognitive deficits, although age of onset in each disorder is different. Pathogenesis of these disorders is complex and contains several features, including genetic risk factors, environmental risk factors, and sites of abnormalities in the brain. Although several hypotheses have been postulated, they seem to be insufficient to explain how brain alterations associated with symptoms in these disorders develop at distinct developmental stages. Development of ASD appears to be related to cerebellar dysfunction and subsequent thalamic hyperactivation in early childhood. By contrast, schizophrenia seems to be triggered by thalamic hyperactivation in late adolescence, whereas hippocampal aberration has been possibly initiated in childhood. One of the possible culprits is metal homeostasis disturbances that can induce dysfunction of blood-cerebrospinal fluid barrier. Thalamic hyperactivation is thought to be induced by microglia-mediated neuroinflammation and abnormalities of intracerebral environment. Consequently, it is likely that the thalamic hyperactivation triggers dysregulation of the dorsolateral prefrontal cortex for lower brain regions related to social cognition. In this review, we summarize the brain aberration in ASD and schizophrenia and provide a possible mechanism underlying social cognitive deficits in these disorders based on their distinct ages of onset.

show abstract

Iron deficiency in children with global developmental delay and autism spectrum disorder

Abstract: Iron deficiency and iron deficiency anaemia were more common in this clinical sample of children with global developmental delay and/or ASD than in the general population.

Cited by 48 publications

References 40 publications

Sleep in Autism Spectrum Disorders

Sleep in Autism Spectrum Disorders

Iron Status of Infants and Toddlers Age 6 to 18 Months and Association with Type of Milk Consumed from DNSIYC Secondary Analysis

Involvement of Neuroinflammation during Brain Development in Social Cognitive Deficits in Autism Spectrum Disorder and Schizophrenia

Contact Info

Product

Resources

About