Iron deficiency does not compromise the diagnosis of high HbA2   thalassemia trait

Passarello, Cristina; Giambona, Antonino; Cannata, Monica; Vinciguerra, Margherita; Renda, Disma; Maggio, Aurelio

doi:10.3324/haematol.2011.052357

Cited by 31 publications

(27 citation statements)

References 8 publications

(2 reference statements)

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“…This implies that the decline in HbA2 with iron deficiency, if any, is subtle and unlikely to impact HbA2-based screening of bTT. This was corroborated by Passarello et al [7] in a recent study on 170 iron-deficient individuals who underwent molecular screening for bTT. Mean of HbA2 values in their patients was 4.9 AE 1.29%, well within the thalassemic range.…”

Section: Discussionsupporting

confidence: 64%

“…This was corroborated by Passarello et al . in a recent study on 170 iron‐deficient individuals who underwent molecular screening for βTT. Mean of HbA2 values in their patients was 4.9 ± 1.29%, well within the thalassemic range.…”

Section: Discussionmentioning

confidence: 99%

“…A reportedly lowered HbA2 in the presence of IDA [6] is worrying in light of the high prevalence of combined IDA + bTT in India [4,5]. The current consensus from large data, however, is that HbA2 remains reliably raised even in the presence of IDA in bTT, at least the high HbA2 ones [1,7]. Smaller studies from India have also corroborated this finding [4].…”

Section: Introductionmentioning

confidence: 99%

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Impact of iron deficiency on hemoglobin A2% in obligate β‐thalassemia heterozygotes

Sharma

Das

Trehan

et al. 2014

Int J Lab Hematology

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of iron deficiency on hemoglobin A2% in obligate β‐thalassemia heterozygotes

Sharma

Das

Trehan

et al. 2014

Int J Lab Hematology

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“…And the patients with borderline HbA2 values (n=55) who were further tested by ARMS-PCR showed presence of different -thalassemia mutations prevalent in this part of the country in a total of 5 cases. In all these, further testing for iron profile revealed concomitant iron deficiency anemia; which could explain the reason Article Table 1 17 However, the possibility of -thalassemia should also be considered. 18 The inherited hemoglobin disorders cause considerable pain and suffering to the patients and their families and are a major drain on health resources in the country.…”

Section: Discussionmentioning

confidence: 95%

The Prevalence and Characterization of β-Thalassemia Trait by Using High-Performance Liquid Chromatography among the Rural Population in West Bengal, India

Maji

Mandal

Bera³

et al. 2014

Thalassemia Reports

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Hemoglobinopathies, common genetic disorders of hemoglobin, can be prevented by population screening and genetic counseling. Identification of these disorders is immensely important epidemiologically and aid in prevention of more serious hemoglobin disorders. Thalassemia is the commonest monogenic disorder in India, which belongs to the thalassemia belt of the world. The present study was undertaken to find out the characteristics of -thalassemia trait and spectrum of this disorder among the rural population, screened under the hospital-based screening program in West Bengal, a state in eastern part of India. This study was carried out in school and college students, newly married couples and pregnant women after proper counseling in the rural areas of five southern districts of this state. Blood samples were tested by high-performance liquid chromatography. Total 1429 -thalassemia traits were detected by random screening from this population. The mean value of HbA 2 of the study population, having -thalassemia trait is 4.9%. The prevalence (10.5%) of -thalassemia trait in West Bengal is higher than other parts of the country. These data are likely to help us in future planning for screening programmes in rural areas of West Bengal, India.

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“…However, other studies have shown no significant difference in HbA 2 levels in such patients [7, 8]. The reduction in HbA 2 levels in patients with concomitant BTT and IDA has been suggested to interfere in the diagnosis of the former.…”

Section: Introductionmentioning

confidence: 95%

Coexisting Iron Deficiency Anemia and Beta Thalassemia Trait: Effect of Iron Therapy on Red Cell Parameters and Hemoglobin Subtypes

et al. 2014

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Background. Coexistence of iron deficiency anemia (IDA) and beta thalassemia trait (BTT) has been the topic of few studies. However, no study from our country was found evaluating the effect of iron therapy in patients with concomitant IDA and BTT. Methods. Over a period of two years, 30 patients with concomitant IDA and BTT were included. All the patients had a complete blood count, serum iron studies, and thalassemia screening using BIORADTM hemoglobin testing system. The patients received oral iron therapy in appropriate dosages for a period of twenty weeks, after which all the investigations were repeated. Appropriate statistical methods were applied for comparison of pre- and posttherapy data. Results. All except two patients were adults with a marked female preponderance. Oral iron therapy led to statistically significant improvement in hemoglobin, red cell indices (P < 0.05), and marked change in serum iron, ferritin, and HbA2 levels (P < 0.001). There was a significant reduction in the total iron binding capacity levels. Conclusion. The present study shows the frequent occurrence of iron deficiency anemia in patients with beta thalassemia trait, which can potentially confound the diagnosis of the latter. Hence, iron deficiency should be identified and rectified in patients with suspicion of beta thalassemia trait.

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Iron deficiency does not compromise the diagnosis of high HbA2 thalassemia trait

Cited by 31 publications

References 8 publications

Impact of iron deficiency on hemoglobin A2% in obligate β‐thalassemia heterozygotes

Impact of iron deficiency on hemoglobin A2% in obligate β‐thalassemia heterozygotes

The Prevalence and Characterization of β-Thalassemia Trait by Using High-Performance Liquid Chromatography among the Rural Population in West Bengal, India

Coexisting Iron Deficiency Anemia and Beta Thalassemia Trait: Effect of Iron Therapy on Red Cell Parameters and Hemoglobin Subtypes

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