Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells
Megan R. Teh,
Nancy Gudgeon,
Joe N. Frost
et al.
Abstract:Iron is an irreplaceable co-factor for metabolism. Iron deficiency affects >1 billion people, causing symptoms including anaemia and impaired immunity. Nevertheless, precisely how iron deprivation impacts immune cell function remains poorly characterised. We therefore interrogated how physiologically low iron availability affected activated CD8+ T cell metabolism and function, using multi-omic and metabolic labelling approaches. Iron limitation profoundly stalled proliferation without influencing cell viabi… Show more
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