Iron Deficiency Anemia in Women

Friedman, Arnold J.; Shander, Aryeh; Martin, Stéphanie; Calabrese, Rebecca; Ashton, Maria E.; Lew, Indu; Seid, Melvin H.; Goodnough, Lawrence T.

doi:10.1097/ogx.0000000000000172

Cited by 30 publications

(15 citation statements)

References 64 publications

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“…The median baseline ferritin level in our fasting subjects was 34 ng/mL. While some biochemical diagnostic thresholds usually involve a serum ferritin level of <15 ng/mL, other guidelines have suggested ferritin thresholds of 30 ng/mL and/or fasting TSAT levels of <20% to confirm an iron deficiency [23,24]. Accordingly, we described our sub-group with a ferritin level < the median at baseline as having relative iron depletion.…”

Section: Discussionmentioning

confidence: 99%

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Novel Iron-Whey Protein Microspheres Protect Gut Epithelial Cells from Iron-Related Oxidative Stress and Damage and Improve Iron Absorption in Fasting Adults

Wang

Radics²,

Whelehan³

et al. 2017

Acta Haematol

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Background: Iron food fortification and oral iron formulations are frequently limited by poor absorption, resulting in the widespread use of high-dose oral iron, which is poorly tolerated. Methods: We evaluated novel iron-denatured whey protein (Iron-WP) microspheres on reactive oxygen species (ROS) and viability in gut epithelial (HT29) cells. We compared iron absorption from Iron-WP versus equimolar-dose (25 mg elemental iron) ferrous sulphate (FeSO₄) in a prospective, randomised, cross-over study in fasting volunteers (n = 21 per group) dependent on relative iron depletion (a ferritin level ≤/>30 ng/mL). Results: Iron-WP caused less ROS generation and better HT29 cell viability than equimolar FeSO₄. Iron-WP also showed better absorption with a maximal 149 ± 39% increase in serum iron compared to 65 ± 14% for FeSO₄ (p = 0.01). The response to both treatments was dependent on relative iron depletion, and multi-variable analysis showed that better absorption with Iron-WP was independent of baseline serum iron, ferritin, transferrin saturation, and haemoglobin in the overall group and in the sub-cohort with relative iron depletion at baseline (p < 0.01). Conclusions: Novel Iron-WP microspheres may protect gut epithelial cells and improve the absorption of iron versus FeSO₄. Further evaluation of this approach to food fortification and supplementation with iron is warranted.

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Section: Discussionmentioning

confidence: 99%

“…It is also associated with poor immunity, frequent infections, headache, hair loss, brittle nails, and cognition problems [3,6,23]. The median baseline ferritin level in our fasting subjects was 34 ng/mL.…”

Section: Discussionmentioning

confidence: 99%

Novel Iron-Whey Protein Microspheres Protect Gut Epithelial Cells from Iron-Related Oxidative Stress and Damage and Improve Iron Absorption in Fasting Adults

Wang

Radics²,

Whelehan³

et al. 2017

Acta Haematol

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“…Iron deficiency anaemia markedly impairs the quality of life in child-bearing-age women and may result in fatigue, reduced exercise tolerance, reduced concentration, and impaired emotional control manifesting as depression, anxiety, stress or irritability, restless leg syndrome, and hair loss [4][5][6] . During pregnancy there may be additional detrimental effects on maternal and fetal outcomes.…”

Section: Clinical Consequences Of Iron Deficiencymentioning

confidence: 99%

“…IV iron therapy in obstetrics and gynaecology is recommended in United Kingdom, Germany, Switzerland, Scandinavia, Spain, Eastern Europe, Russia, Pakistan, India, Malaysia, Singapore, Indonesia, China, Thailand, Peru, Argentina, Chile, Australia, and the United States 2,4,6,[10][11][12][13][14]22,40,[43][44][45][46][47][48][49][50][51] . IV iron therapy is considered when oral iron therapy fails or is expected to fail in the following clinical scenarios: oral iron therapy intolerance 2,4,6,[10][11][12][13][14]22,40,[43][44][45][46][47]49,50 , oral iron therapy unresponsiveness 2,4,6,[10][11][12][13][14]22,40,[43][44]…”

Section: Stratificationmentioning

confidence: 99%

Iron therapy in obstetrics and gynaecology: a review

2019

Hong Kong J Gynaecol Obstet Midwifery

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There are three problems in managing iron deficiency anaemia in child-bearing-age women: lack of awareness of the condition by both patient and clinician, inexperience in the diagnosis, and lack of familiarity with available oral and intravenous iron therapy. Iron deficiency is common in women, from menarche, through growth spurt in puberty, pregnancy, and postpartum, and until menopause. To screen for underlying iron deficiency, a haemoglobin cutoff for anaemia is used. Iron deficiency anaemia must be excluded for patients with haemoglobin level below the cutoff. Oral iron therapy is effective in treating iron deficiency anaemia. Low-dose alternate-day oral iron therapy is recommended (rather than daily iron dose). It is crucial to accompany oral iron therapy with vitamin C. Intravenous iron therapy, particularly with third-generation iron compounds, is safe, effective, and faster acting than oral iron therapy.

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“… 8 , 10 Hence, some studies provide data supporting the use of higher ferritin thresholds for diagnosis, such as 30 or 100 ng/mL. 11 , 12 …”

mentioning

confidence: 99%

Challenges in the diagnosis of iron deficiency anemia in aged people

Moraes

Figueiredo

2017

Revista Brasileira de Hematologia e Hemoterapia

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Iron Deficiency Anemia in Women

Abstract: Clinicians should routinely identify and treat IDA, thereby decreasing its negative impact on health and quality of life of women.

Cited by 30 publications

References 64 publications

Novel Iron-Whey Protein Microspheres Protect Gut Epithelial Cells from Iron-Related Oxidative Stress and Damage and Improve Iron Absorption in Fasting Adults

Novel Iron-Whey Protein Microspheres Protect Gut Epithelial Cells from Iron-Related Oxidative Stress and Damage and Improve Iron Absorption in Fasting Adults

Iron therapy in obstetrics and gynaecology: a review

Challenges in the diagnosis of iron deficiency anemia in aged people

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