Iron-deficiency anemia as a risk factor for acute lower respiratory tract infections in children younger than 5 years

Behairy, Ola Galal; Mohammad, Osama I.; El-Shaer, Osama S.

doi:10.4103/ejb.ejb_67_17

Cited by 7 publications

(22 citation statements)

References 13 publications

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“…Table (2) and figure (1) show that there were statistically significant decrease in Zinc among Cases than Controls group.…”

Section: Resultsmentioning

confidence: 83%

“…There was no statistically significant difference between cases group and control group regarding Age (month) and Sex Table (1).…”

Section: Resultsmentioning

confidence: 86%

“…Intense lower respiratory plot contaminations (ALRTIs) in kids more youthful than 5 years are the primary driver of youth dismalness and mortality worldwide and address practically 60% of hospitalizations inferable from baby irresistible infection [1].…”

Section: Introductionmentioning

confidence: 99%

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Blood Zinc Level in Benha Children with Lower Respiratory Tract Infections

Shaheen

Fayed

Sobeh

et al. 2021

Benha Journal of Applied Sciences

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“…Table (2) and figure (1) show that there were statistically significant decrease in Zinc among Cases than Controls group.…”

Section: Resultsmentioning

confidence: 83%

“…There was no statistically significant difference between cases group and control group regarding Age (month) and Sex Table (1).…”

Section: Resultsmentioning

confidence: 86%

See 1 more Smart Citation

Blood Zinc Level in Benha Children with Lower Respiratory Tract Infections

Shaheen

Fayed

Sobeh

et al. 2021

Benha Journal of Applied Sciences

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“…Iron deficiency anemia was also studied as a risk factor in children presenting with Pneumonia at a tertiary care hospital setup in Egypt in 2015. According to that study, Children with IDA had four times more susceptibility of acquiring pneumonia then control children without IDA 15 . It also studied the possibility of recurrent chest infections in children IDA which was also found to be higher.…”

Section: Discussionmentioning

confidence: 93%

Association of Iron Deficiency Anemia With Acute Lower Respiratory Tract Infections in Children

Nawaz

Hussain

Khushdil

et al. 2021

PAFMJ

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Objective: To establish association between acute lower respiratory tract infection and iron deficiency anemia. Study Design: Case-control study. Place and Duration of Study: Pediatrics Department, Pak Emirates Military Hospital, Rawalpindi, from Dec 2017 to May 2018. Methodology: A total of 100 children with age ranging from 6-60 months were selected for this study with 50 being in each group. Study group constituted of children presenting with acute lower respiratory tract infection and healthy children presenting to outpatient were taken as controls. Hemoglobin levels (<11g/dl), mean corpuscular volume (<70fl), Serum Ferritin (<30ng/ml) and red blood cell Morphology were used to determine iron deficiency anemia. Patients meeting the WHO criteria were labeled to have acute lower respiratory tract infection. Results: The frequency of iron deficiency was found to be 40 (80%) in cases and only 34 (17%) in healthy controls. A significant association was found between iron deficiency anemia and acute lower respiratory tract Infection with an odds ratio of 7.76 and a significant p-value of <0.01. Conclusions: Iron deficiency anemia has an increased association of up to seven times in children with acute lower respiratory tract infections as compared to healthy children thus highlighting it as a significant risk factor.

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“…Следовательно, дефицит железа отрицательно сказывается на развитии когнитивных функций у детей раннего возраста, замедляет работу иммунной системы и увеличивает риск инфекционных заболеваний [5]. В мире прово-Актуальні проблеми сучасної медицини дятся исследования связи железодефицитной анемии с показателями специфического и неспецифического иммунитета [6].…”

Section: Introductionunclassified

Changes in Some Fractions of Cytokines in Children With Iron Deficiency Anemia

Najafova¹

2021

Act. Probl. of the Modern Med.

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The aim of the study was to investigate the effect of iron deficiency anaemia on certain cytokine fractions (IL-2, INF-γ, TNF-α) in children aged 6 months to 5 years in Azerbaijan. Methods. The study involved 123 children. According to the hematological and biochemical blood parameters of children aged 6 months to 5 years, 95 children (58 boys, 37 girls) were diagnosed as having anaemia of varying degrees: 32 children had mild iron deficiency anaemia, 37 children had moderate iron deficiency anaemia, and 26 children had severe iron deficiency anaemia. Results. The study demonstrates the level of INF-γ is lower in the general group of children with iron deficiency anaemia compared to the control group (2.5±1.2 pg/ml and 3.9±1.6 pg/ml, respectively). In the general group of children with iron deficiency anaemia, the average correlation coefficient (r=+0.7) between INF-γ with haemoglobin and with serum ferritin (r=+0.6) has been shown. Taking into account the weakening of INF-γ in children with iron deficiency anaemia during the study period, we investigated the annual incidence of acute respiratory viral infections among the general group of children with iron deficiency anaemia and the control group (63.2% and 25%, respectively). There were no significant changes in TNF-α value in children of the general group with iron deficiency anaemia compared to the control group (2.7±1.5 pg / ml, 2.7±1.1 pg / ml, respectively). The IL-2 index in the general group was lower than in the control group (1.6±1.0 pg / ml, 2.9±1.6 pg / ml, respectively). Children in the general group with iron deficiency anaemia had an average correlation coefficient (r=+0.65) IL-2 with haemoglobin and a high correlation coefficient with serum ferritin (r=+0.8). The incidence of pneumonia in the group of children with iron deficiency anaemia was 17.9%. Conclusion. The obtained lowered results of İNF-γ and İL-2 in comparison with the control group and an increased incidence of respiratory diseases indicate a possible reduction in cellular immunity.

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Iron-deficiency anemia as a risk factor for acute lower respiratory tract infections in children younger than 5 years

Cited by 7 publications

References 13 publications

Blood Zinc Level in Benha Children with Lower Respiratory Tract Infections

Blood Zinc Level in Benha Children with Lower Respiratory Tract Infections

Association of Iron Deficiency Anemia With Acute Lower Respiratory Tract Infections in Children

Changes in Some Fractions of Cytokines in Children With Iron Deficiency Anemia

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