Iron deficiency anemia as a risk factor in childhood asthma

Eissa, Sherif A.; Ali, Mohammad; Ibrahim, S. A.; Abdelgwad, Eman Ramadan; Soliman, Nivin Samir Abd Elmagid

doi:10.1016/j.ejcdt.2016.05.004

Cited by 7 publications

(11 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the study by Bener et al, ferritin was identified as a significant predictor of asthma after adjustment for other variables (35), which confirms the results of the present study. Eissa et al also indicated a positive correlation between ferritin levels and pulmonary function parameters (FEV1, FVC, FEV1/FVC, and PEF) in children with iron deficiency anemia (36), which is consistent with the results of the present study. These studies, along with the results of the present study, indicate the significant role of iron in asthma.…”

Section: Discussionsupporting

confidence: 93%

“…In this study, mean Hb levels was 10.58 g/dL in the asthmatic group and 11.75 in the control group (35), which is very close to the mean Hb levels in the children of our study (10.4 g/dL in the case group and 11.5 g/dL in the control group). Also, in a prospective cohort study on 100 outpatient children aged 6 -16 years, the results indicated a significantly higher prevalence of asthma in children with iron deficiency anemia and a positive correlation between Hb levels and pulmonary function parameters (FEV1, FVC, FEV1/FVC, and PEF) in this group (36), which is in line with the results of the present study. Further research has proven the role of mothers' anemia on the higher risk of asthma in their children, which indicates the significant association of anemia and asthma, not only in the patients but also in their next-generation (37), which is in line with the results of the present study, emphasizes the importance of treating anemia for prevention of asthma.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Breastfeeding, Serum Level of Hemoglobin and Ferritin Associated with the Risk of Asthma in Children: A Case-Control Study

et al. 2020

View full text Add to dashboard Cite

Background: During recent decades, there has been a dramatic increase in the prevalence of asthma in children. There is low-grade quality evidence that breastfeeding and anemia are associated with a reduced risk of asthma in children up to 5 years of age. Objectives: Regarding the high prevalence of anemia and asthma in Iranian children, we aimed to evaluate the risk factors for asthma in children. Methods: The present case-control study examined 110 children (55 cases and 55 controls) aged 3 to 12, admitted to Shahroud educational hospitals from March 2017 to February 2018. The children diagnosed based on the Global Initiative for Asthma criteria, by a specialist physician, were selected as the case group and those admitted to other hospital wards for diseases (such as orthopedic and nephrology), other than respiratory problems were selected as the control group. Multivariable logistic regression was used to find asthma risk factors. P < 0.05 was considered statistically significant. Results: Of 110 children, 63 (57.3%) were boy and mean (± standard deviation (SD)) age of the participants was 7.23 (± 4.17) years and mean weight was 29.6 (± 21.6) kg. Most of the children (76.4%) were fed by breast milk during infancy. Mean (± SD) Hb in the case group was 10.4 (± 2.5) g/dL and in the control group was 11.5 (± 2.3) g/dL (P = 0.01). The prevalence of anemia was 72.7% and 50.9% in the case and control group, respectively (P < 0.001). After controlling for potential confounders, breastfeeding (OR breast milk only vs. formula only = 2.23, P = 0.01), serum level of hemoglobin (OR = 0.13, P = 0.002) and ferritin (OR = 0.32, P = 0.04) were significantly associated with the risk of asthma. Conclusions: Our study found the role of low duration of breastfeeding and ferritin deficiency as a risk factor for development of asthma in children. This finding emphasizes that iron supplementation along with breastfeeding in childhood may prevent asthma and hence reduce the children's mortality and morbidity rates associated with asthma.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Breastfeeding, Serum Level of Hemoglobin and Ferritin Associated with the Risk of Asthma in Children: A Case-Control Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Notably 41% of those women had normal baseline hemoglobin prior to iron supplementation, implicating that iron replacement has a primary role in symptoms improvement. 11 Another study about children had suggested that anemia associated with asthma, especially due to iron deficiency. 12 In this study, the only significant statistical association was in peak expiratory flow rate between iron deficiency anemia which is further supported by an assumption that higher iron stores were associated a lower prevalence of asthma in US women 20-49 years of age as well as a decrease in body iron is linked to a decrease in FEV1 due to increase in tissue iron demands suggesting that tissue and body iron may influence lung function.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2020

HTIJ

View full text Add to dashboard Cite

BackgroundAsthma is a prevalent chronic health condition, affecting approximate 7.7 % of adults working age that is characterized by variable respiratory symptoms and variable airflow limitation induced by chronic airway inflammation. 1 Acute exacerbations are characterized by decrease in expiratory airflow (PEF or FEV1) that may range from mild to life threatening state as according to measurement of PEF, FEV1 2,3 as well as the need to use systemic corticosteroids. 4,5 Normally, about 97 percent of the oxygen transported from the lungs to the tissues in the red blood cells based on Oxygen -Hemoglobin Dissociation Curve. 6 WHO had defined anemia as less than 130 g / L for men and 120 g / L for women, without the distinction between age and race. 7Iron deficiency is also one of the most common nutritional deficiencies is thought to be more prevalent in population at greatest risk for asthma assuming that these tow conditions may be linked. 8 In animal models, a low iron diet resulted in pronounced asthma in mouse model of allergic asthma, that is mediated by increased mast cell reactivity in the setting of low iron. 9 ObjectivesThis study aimed to define the clinical impact of anemia in asthma patient and to assess its correlation with severity of presentation. Patients and method Study design and settingA hospital based cross sectional study was conducted over the period of ten months from the 1 st of February 2017 till the 1st of December 2018 in the medical -ward and the outpatient respiratory clinic at Al-Emmamian Al-Kadhimain Medical city and Baghdad teaching hospital. Population and work upA total of 50 bronchial asthma patients as confirmed by specialist based on clinical ground and pulmonary function with reversibility were included in this study. They were presented either as chronic stable asthma for follow up or in acute exacerbation. Data were collected from each patient using a questionnaire that included age, gender, duration of disease, and treatment lines in addition to assessment of severity using PEFR (peak expiratory flow rate) as well as pulmonary function test by FEV1 (forced expiratory volume in 1 st second). Those patient with history of COPD (chronic obstructive pulmonary disease), bronchiectasis, blood loss, hemolysis and primary hematological malignancy were excluded from this study in addition to those with smoking history.Every eligible patient was assessed to define FEVI in addition to PEF (peak expiratory flow) rate and Oxygen saturation which

show abstract

“…У разі надлишку заліза блокується взаємодія IRE з IRP, не синтезуєть ся TfR, і залізо не потрапляє в ентероцит [1]. При цьому підвищення фактора високого залі за (HFE), який зв'язує TfR, перешкоджає взає модії останнього з трансферином, не утворю ється ендосома, таким чином, залізо не прони кає в тканини [4,6].…”

Section: актуальністьunclassified

Evaluation of the level of reduced proteins and their recipers in the blood syrobal in children with bronchial asthma, depending on indicators of the external respiratory function

Dudnyk¹,

Zhmurchuk²

2019

UJPP

View full text Add to dashboard Cite

Мета-оцінити рівень залізовмісних білків та їх рецепторів у сироватці крові дітей, хворих на бронхіальну астму (БА), залежно від показника функції зовнішнього дихання. Пацієнти та методи. Відповідно до поставленої мети обстежено 227 дітей, хворих на БА, віком від 6 до 17 років. В усіх обстежених визначено кількість заліза в сироватці крові, загальну залізозв'язуючу здатність, латентну залізозв'язуючу здатність, коефіцієнт насичення трансферину (КНТ) залізом, рівень феритину, вміст розчинних рецепторів до трансферину (sTfR), індекс sTfR/log феритин (>1,5-латентний дефіцит заліза). Функцію зовнішнього дихання (об'єм форсованого видиху за секунду-ОФВ1) досліджено методом спірографії на апараті Spirolab III. Результати. Проведеним дослідженням визначено, що мікроцитоз у дітей, хворих на БА, із тяжким ступенем обструкції дихальних шляхів зустрічався на 53,76% частіше, ніж у пацієнтів із нормоцитозом. За отриманими даними, показники ферокінетики в обстежених дітей, хворих на БА, залежали від ступеня обструкції дихальних шляхів. Так, КНТ залізом був нижчим порівняно зі здоровими: у групі дітей із показником ОФВ1 >80%на 10,4%; у групі дітей із показником ОФВ1 65-80%-на 18,48%; у групі дітей із показником ОФВ1 50-65%-на 24,79%, у групі дітей із показником ОФВ1 <50%-на 28,59%. Висновки. У дітей, хворих на БА, із тяжким і середнім ступенем обструкції дихальних шляхів (за показником ОФВ1) дефіцит заліза зустрічався в 10,1 раза і 5,02 раза частіше, ніж у пацієнтів із показником ОФВ1 >80%. Серед показників обміну заліза найбільш суттєвими були зміни КНТ залізом, що вказують на значний позитивний зв'язок між КНТ залізом і ОФВ1 (rxy=0,621 (p=0,026)), а також на помірний зв'язок із піковою об'ємною швидкістю видиху (rxy=0,422 (p=0,033)). Також встановлено позитивний зв'язок між рівнем феритину і показником ОФВ1 (rxy=0,258 (p=0,024)). Дослідження виконані відповідно до принципів Гельсінської Декларації. Протокол дослідження ухвалений Локальним етичним комітетом (ЛЕК) зазначеної у роботі установи. На проведення досліджень отримано поінформовану згоду хворих та їхніх батьків. Автори заявляють про відсутність конфлікту інтересів. Ключові слова: бронхіальна астма, діти, залізовмісні білки, функція зовнішнього дихання.

show abstract

Iron deficiency anemia as a risk factor in childhood asthma

Cited by 7 publications

References 6 publications

Breastfeeding, Serum Level of Hemoglobin and Ferritin Associated with the Risk of Asthma in Children: A Case-Control Study

Breastfeeding, Serum Level of Hemoglobin and Ferritin Associated with the Risk of Asthma in Children: A Case-Control Study

Untitled

Evaluation of the level of reduced proteins and their recipers in the blood syrobal in children with bronchial asthma, depending on indicators of the external respiratory function

Contact Info

Product

Resources

About