Iron deficiency anemia and restless legs syndrome: is there an electrophysiological abnormality?

Akyol, Ali; Kıylıoğlu, Nefati; Kadıköylü, Gürhan; Bolaman, Ali Zahit; Ozgel, Nihat

doi:10.1016/j.clineuro.2003.07.004

Cited by 38 publications

(26 citation statements)

References 23 publications

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“…It establishes for the first time, a reasonably accurate estimate of RLS prevalence in a community population of patients with IDA referred for treatment. The overall RLS prevalence in IDA is four to five times higher than in the general population (31% vs. 7%) [15], but not the six times higher reported in the very small, prior studies [6,7] not using a validated diagnosis or acknowledging any effort to exclude RLS "mimics" [11]. The important finding, however, is the confirmation of the expected high prevalence of clinically significant RLS in IDA.…”

Section: Discussionmentioning

confidence: 37%

“…The only two prior studies of RLS in patients with IDA reported a very high RLS prevalence of about 40% [6,7]. These studies used small, academic-hospital-based populations with limited, nonvalidated, nonstandardized criteria to make the diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…Moderately severe to severe RLS is a major health problem [4] producing periods of torturous restlessness during sleep often reducing sleep times to 5 hr or less [5]. Presumably RLS occurring with IDA if not adequately treated will have the same adverse health effects, but this has not been previously studied.The only two prior studies of RLS in patients with IDA reported a very high RLS prevalence of about 40% [6,7]. These studies used small, academic-hospital-based populations with limited, nonvalidated, nonstandardized criteria to make the diagnosis.…”

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confidence: 99%

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The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia

et al. 2013

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Restless Legs Syndrome (RLS) a common, under-recognized disorder disrupts sleep and diminishes quality of life. Despite a clear relation between low peripheral iron and increased prevalence and severity of RLS, the prevalence and clinical significance of RLS in iron-deficient anemic (IDA) populations is unknown. In this study all new patients referred for anemia to a community-based hematology practice over a 1-year period (March 2011(March -2012 were included if they had IDA and no RLS treatment. Patients completed a validated questionnaire identifying RLS, blood tests, and a sleep-vitality questionnaire (SVQ). Patients with RLS were compared to patients with no RLS for differences on SVQ, blood tests, baseline characteristics, and sleep quality. Three hundred forty-three patients were evaluated and 251 (89.2% female, average age of 45.6 years) included in the study. The prevalence of clinically significant RLS (RLS sufferers) was 23.9%, nine times higher than the general population. IDA-RLS sufferers reported poorer quality of sleep, decreased sleep time, increased tiredness, and decreased energy during the day compared to patients with IDA without RLS. Blood tests did not relate to RLS diagnosis but RLS was less likely for African-American than Caucasian patients. Clinically significant RLS occurs commonly with IDA producing much greater disruption of sleep and shorter sleep times than does IDA alone. This indicates the need for identification of RLS with IDA and consideration of appropriate therapeutic interventions for this sizeable subgroup: either aggressive iron treatment to reduce the RLS symptoms or medications for RLS or both. Am. J. Hematol. 88:261-264, 2013. V C 2013 Wiley Periodicals, Inc. IntroductionIron deficient anemia (IDA) occurs commonly particularly among American women of child-bearing age [1] The Willis-Ekbom Disease, better known as the restless legs syndrome (RLS) is exacerbated and engendered by reduced peripheral iron stores and therefore should be both common and moderately severe in IDA. RLS is well-defined but commonly over-looked cause of significant morbidity with established relationships to genetics [2] and iron biology [3]. Moderately severe to severe RLS is a major health problem [4] producing periods of torturous restlessness during sleep often reducing sleep times to 5 hr or less [5]. Presumably RLS occurring with IDA if not adequately treated will have the same adverse health effects, but this has not been previously studied.The only two prior studies of RLS in patients with IDA reported a very high RLS prevalence of about 40% [6,7]. These studies used small, academic-hospital-based populations with limited, nonvalidated, nonstandardized criteria to make the diagnosis. The accuracy of these prevalence estimates is therefore questionable. More significantly, the severity of RLS was not reported. RLS has a broad range of severity from a rarely occurring mild annoyance to a clinically significant disease severely impairing sleep, quality of life, health, and ability to work...

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Section: Discussionmentioning

confidence: 37%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia

et al. 2013

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“…The results of the study are consistent with the study by Y Degirmenci et al [5] and the study by Kabakus N et al, [6] Degirmenci Y et al [5] performed nerve conduction study in 52 patients with newly-diagnosed irondeficiency anaemia and 38 healthy controls and found that bilateral median nerve sensory conduction values and sural nerve sensory nerve conduction values are significantly reduced in patients with iron-deficiency anaemia and Kabakus et al recorded the nerve conduction velocity in the median and posterior tibial nerve of 18 individuals with iron-deficiency anaemia compared with 12 healthy controls and found that the nerve conduction velocity was reduced in individuals with iron-deficiency anaemia. [6] However, these results were contradicted by Akyol A et al [7] who concluded that irondeficiency anaemia does not cause significant electrophysiological changes in peripheral nerves.…”

Section: Discussioncontrasting

confidence: 52%

Sensory Nerve Conduction Velocity in Subjects With Iron-Deficiency Anaemia

Kumarasamy¹,

Swaminathan²,

Gorla³

et al. 2016

jemds

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“…In a study of Allen et al 34 , prevalence of clinically significant RLS (RLS sufferers) was 23.9% in 251 patients with IDA, nine times higher than the general population. In another study, the said ratio was reported as 40% 35 . Patients with RLS were excluded from this study.…”

Section: Methodsmentioning

confidence: 92%

Assessment of subjective sleep quality in iron deficiency anaemia

Sönmezer¹,

Ali²,

Korkmaz³

et al. 2015

Afr H. Sci.

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Objectives: We aimed to assess the effect of anemia on subjective sleep quality in patients with iron deficiency anemia (IDA). Methods: One hundred and four patients diagnosed with IDA and 80 healthy individuals, who are gender and age matched, were included in the study. All participants were requested to fill 3 forms: a socio-demographic form (age, gender, marital status, income level and educational status), hospital anxiety and depression (HAD) scale and pittsburgh sleep quality index (PSQI). Results: According to the HAD scale, the average anxiety score was found 9.24±4.37 in patients and 7.58± 4.07 in controls. And, the average depression score was 7.53±4.10 in patients and 6.41±2.74 in controls. The total sleep quality score was 6.71±3.02 in patients and 4.11±1.64 in controls. There was a statistically significant difference in terms of anxiety, depression and sleep quality scores. Linear regression analysis showed no association between anxiety and depression with poor sleeping. Corresponding author: Semiz Murat, Gülhane Tıp Akademisi Psikiyatri AD, TR-06020, Ankara, Turkey. Email:drmuratsemiz@hotmail.com Introduction After a negative iron balance in the body due to reasons such as chronic blood loss, increased iron demand, and absorption disorder, hemoglobin synthesis is compensated by mobilization of iron from stores and when the stores of iron fail to release adequate iron, iron deficiency anemia (IDA) develops 1 . Just like in our country, iron deficiency is the most common cause of anemia in the world and is more prevalent in women than men 2,3 . It has been known that more than 30% of those attending to hospitals in developed countries are anemic and the said ratio is much higher in developing countries.

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Iron deficiency anemia and restless legs syndrome: is there an electrophysiological abnormality?

Cited by 38 publications

References 23 publications

The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia

The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia

Sensory Nerve Conduction Velocity in Subjects With Iron-Deficiency Anaemia

Assessment of subjective sleep quality in iron deficiency anaemia

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