Iron deficiency anemia and affective response in rhesus monkey infants

Golub, Mari S.; Hogrefe, Casey E.; Widaman, Keith F.; Capitanio, John P.

doi:10.1002/dev.20345

Cited by 87 publications

(182 citation statements)

References 37 publications

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“…Reports on normative CBC values for infant monkeys [29–33] indicate that human thresholds for anemia based on hemoglobin are applicable. Colony wide data on 3–4 month infants at CNPRC indicate an incidence of 34/695 (5%) infants with anemia based on this hemoglobin cutoff [34]. Based on this low incidence, there was insufficient power (21%) to detect 10% increased anemia incidence in the small experimental sample.…”

Section: Resultsmentioning

confidence: 99%

Developmental plasticity of red blood cell homeostasis

et al. 2014

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Most human physiologic set points like body temperature are tightly regulated and show little variation between healthy individuals. Red blood cell (RBC) characteristics such as hematocrit (HCT) and mean cell volume (MCV) are stable within individuals but can vary by 20% from one healthy person to the next. The mechanisms for the majority of this inter-individual variation are unknown and do not appear to involve common genetic variation. Here we show that environmental conditions present during development, namely in utero iron availability, can exert long-term influence on a set point related to the RBC life cycle. In a controlled study of rhesus monkeys and a retrospective study of humans, we use a mathematical model of in vivo RBC population dynamics to show that in utero iron deficiency is associated with a lowered threshold for RBC clearance and turnover. This in utero effect is plastic, persisting at least two years after birth and after the cessation of iron deficiency. Our study reports a rare instance of developmental plasticity in the human hematologic systems and also shows how mathematical modeling can be used to identify cellular mechanisms involved in the adaptive control of homeostatic set points.

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Section: Resultsmentioning

confidence: 99%

Developmental plasticity of red blood cell homeostasis

et al. 2014

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“…The BBA Program consists of a battery of tests designed to assess infants' behavioral and physiological reactivity as described in detail elsewhere [25–26]. Briefly, infants were removed from their home cages and separated from their mothers for a 25 h period between 3–4 months of age.…”

Section: Methodsmentioning

confidence: 99%

Early Predictors of Impaired Social Functioning in Male Rhesus Macaques (Macaca mulatta)

et al. 2016

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Autism spectrum disorder (ASD) is characterized by social cognition impairments but its basic disease mechanisms remain poorly understood. Progress has been impeded by the absence of animal models that manifest behavioral phenotypes relevant to ASD. Rhesus monkeys are an ideal model organism to address this barrier to progress. Like humans, rhesus monkeys are highly social, possess complex social cognition abilities, and exhibit pronounced individual differences in social functioning. Moreover, we have previously shown that Low-Social (LS) vs. High-Social (HS) adult male monkeys exhibit lower social motivation and poorer social skills. It is not known, however, when these social deficits first emerge. The goals of this study were to test whether juvenile LS and HS monkeys differed as infants in their ability to process social information, and whether infant social abilities predicted later social classification (i.e., LS vs. HS), in order to facilitate earlier identification of monkeys at risk for poor social outcomes. Social classification was determined for N = 25 LS and N = 25 HS male monkeys that were 1–4 years of age. As part of a colony-wide assessment, these monkeys had previously undergone, as infants, tests of face recognition memory and the ability to respond appropriately to conspecific social signals. Monkeys later identified as LS vs. HS showed impairments in recognizing familiar vs. novel faces and in the species-typical adaptive ability to gaze avert to scenes of conspecific aggression. Additionally, multivariate logistic regression using infant social ability measures perfectly predicted later social classification of all N = 50 monkeys. These findings suggest that an early capacity to process important social information may account for differences in rhesus monkeys’ motivation and competence to establish and maintain social relationships later in life. Further development of this model will facilitate identification of novel biological targets for intervention to improve social outcomes in at-risk young monkeys.

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“…The BBA is a highly standardized test battery assessing a variety of measures over a 25-h period [see Golub et al (2009) for a detailed description]. As part of the procedure, all infants are observed for 5 min at the beginning and near the end of the 25-h period during which they are separated from their mothers for testing.…”

Section: General Methodsmentioning

confidence: 99%

Depressive-like behavioral response of adult male rhesus monkeys during routine animal husbandry procedure

Hennessy

McCowan

Jiang

et al. 2014

Front. Behav. Neurosci.

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Social isolation is a major risk factor for the development of depressive illness; yet, no practical nonhuman primate model is available for studying processes involved in this effect. In a first study, we noted that adult male rhesus monkeys housed individually indoors occasionally exhibited a hunched, depressive-like posture. Therefore, Study 2 investigated the occurrence of a hunched posture by adult males brought from outdoor social groups to indoor individual housing. We also scored two other behaviors—lying on the substrate and day time sleeping—that convey an impression of depression. During the first week of observation following individual housing, 18 of 26 adult males exhibited the hunched posture and 21 of 26 displayed at least one depressive-like behavior. Over 2 weeks, 23 of 26 males showed depressive-like behavior during a total of only 20 min observation. Further, the behavior during the first week was positively related to the level of initial response to a maternal separation procedure experienced in infancy. In Study 3, more than half of 23 adult males of a new sample displayed depressive-like behavior during 10 min of observation each of Weeks 7–14 of individual housing. The surprisingly high frequency of depressive-like behavior in Studies 2 and 3 may have been due to recording behavior via camera with no human in the room to elicit competing responses. These results suggest that a common animal husbandry procedure might provide a practical means for examining effects of social isolation on depression-related endpoints in a nonhuman primate. The findings also suggest that trait-like differences in emotional responsiveness during separation in infancy may predict differences in responsiveness during social isolation in adulthood.

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Iron deficiency anemia and affective response in rhesus monkey infants

Cited by 87 publications

References 37 publications

Developmental plasticity of red blood cell homeostasis

Developmental plasticity of red blood cell homeostasis

Early Predictors of Impaired Social Functioning in Male Rhesus Macaques (Macaca mulatta)

Depressive-like behavioral response of adult male rhesus monkeys during routine animal husbandry procedure

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