Iron Deficiency and/or Thalassæmia Trait

Srivastava, Prachi; Bevington, J.M.

doi:10.1016/s0140-6736(73)90637-5

Cited by 66 publications

(48 citation statements)

References 1 publication

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“…These efforts include the use of red blood cell (RBC) indices and mathematic formulas derived from RBC indices [2,3,4,5,6,7,8,9]. The indices have been validated by several investigators, and their applicability has been demonstrated by comparing the results of studies between IDA and β-thalassemia trait patient groups [10,11,12,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

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Proxy Indicators for Identifying Iron Deficiency among Anemic Vegetarians in an Area Prevalent for Thalassemia and Hemoglobinopathies

Wongprachum

Sanchaisuriya

et al. 2012

Acta Haematol

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Background and Aims: The study aimed to determine the proportion of iron deficiency (ID) anemia (IDA) among vegans in northeast Thailand and to explore whether mathematical formulas derived from red blood cell (RBC) indices are applicable for IDA screening in the study population. Methods: Blood samples from 234 individuals (age 6–45 years) living in a vegan community were taken. Complete blood cell count, serum ferritin, hemoglobin profiles and DNA analysis for α-thalassemia were determined. Anemia was defined using the WHO criteria adjusted for age and sex. Serum ferritin <15 ng/ml was considered as ID. A number of mathematical formulas derived from RBC indices were applied to screen ID among anemic individuals. Results: Anemia was found in 41.5% (95% CI = 35.1–48.1%) of the study participants. The overall proportion of thalassemia and hemoglobinopathies was 56.4% (95% CI = 49.8–62.9%). Of the anemic participants, 45.4% had ID. Based on the receiver-operating characteristic curve analysis, 4 formulas were applicable for predicting ID among anemic individuals (highest sensitivity of 86.4%). Conclusions: The proposed formulas might be used as proxy indicators for the identification of ID among anemic children and adult vegans if more sophisticated laboratory determinations are not available due to limited financial resources.

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Section: Introductionmentioning

confidence: 99%

“…This study aimed to determine the prevalence of anemia, ID and IDA among children and adults aged 6–45 years living in a vegan community in the northeast of Thailand. An attempt was made to explore whether a number of the suggested indices [3,4,5,6,7,8,9] can be applied for screening for IDA among the study population.…”

Section: Introductionmentioning

confidence: 99%

Proxy Indicators for Identifying Iron Deficiency among Anemic Vegetarians in an Area Prevalent for Thalassemia and Hemoglobinopathies

Wongprachum

Sanchaisuriya

et al. 2012

Acta Haematol

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“…On the other hand, typical thalassemia diognosis methods using red blood cell indices [5][6][7] belatedly reveal the disease because of changes in hemoglobin during fetal and postnatal periods 8,9 . Therefore, health system managers today prefer to employ preventive measures through different strategies, including pre-marriage screening of couples, genetic counselling, and informing at risk couples.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of fingerprint patterns: An explorative study on beta-thalassemia diagnosis

Solhi

Hashemieh

Nejad

et al. 2010

Bangladesh Med Res Counc Bull

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Rapid diagnosis of major β thalassemia along with certain preventive measures is of utmost significance. The present study aims to compare the fingerprints in Major β thalassemic patients (67) and in their parents (76 with minor thalassemia) with the normal fingerprints of control group (144). A forensic medical examiner determined fingerprint types of arch, loop, whorl and other types. Like normal individuals, loop fingerprint pattern was found to be the most common fingerprint type among thalassemic patients. However, the number of whorl fingerprints in all fingers in thalassemic patients was greater than that of normal individuals and the number of loop fingerprints was smaller (p<0.05). Arch type fingerprint pattern was less frequent in major thalassemic patients compared to minor thalassemic ones (p<0.05). The findings show that the number of whorl fingerprint patterns in thalassemic patients was greater than that of normal individuals, while the number of loop fingerprint patterns being smaller and the frequency of arch fingerprint pattern in patients with major thalassemia was lower than that of minor thalassemic patients. Therefore, one may choose fingerprint pattern as a simple, affordable and appropriate screening method to help detect the afflicted patients and prevent severe cases of thalassemia.

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“…The indices proposed by Ricerca et al (1987), Shine and Lal (1977) and Green and King (1989) worked reasonably well for detecting beta-thalassaemia traits and most except those proposed by Shine and Lal (1977) and Srivastava and Bevington (1973) were sensitive for detecting iron deficiency. Overall, the most accurate indices appeared to be those proposed by Green and King (1989) and Ricerca et al (1987).…”

Section: Resultsmentioning

confidence: 92%

Screening for the beta-thalassaemia trait: hazards among populations of West African Ancestry

et al. 2011

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The aim of this study was to examine the accuracy and characteristics of detecting the betathalassaemia trait in populations of West African ancestry. School children, aged 16-19 years, in Manchester Parish, Jamaica were screened to detect the genes which could give rise to offspring with sickle cell disease. Haematological indices and HbA 2 levels in subjects with an MCH≤26 pg and an RDW<18.0 with DNA analysis in those with indices consistent with the beta thalassaemia trait were measured. The performance of published discriminant indices in distinguishing iron deficiency and betathalassaemia trait in this population was assessed. Of 10,148 subjects, 1,739 (17.1%) had an AA haemoglobin phenotype and red cell indices consistent with betathalassaemia (MCH values≤26 pg, RDW<18.0) requiring estimations of HbA 2 levels. HbA 2 levels were ≥3.5% in 112 and beta-thalassaemia mutations were identified in 77 of these including the −88 C>T mutation in 35 (45%), −29 A>G in 19 (25%), −90 C>T in 7 (9%), the IVS II-849 A>G in 5 (6%) with smaller contributions from five other mutations. Discriminant indices performed poorly in the differentiation of iron deficiency and the beta-thalassaemia trait. Detection of the beta-thalassaemia trait is relatively insensitive in populations of West African ancestry partly because of the mild defects characterising beta-thalassaemia in this population and also the high prevalence of deletional alpha thalassaemia. More sensitive indicators are required for beta-thalassaemia detection to inform such populations at risk of offspring with sickle cell disease.

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Iron Deficiency and/or Thalassæmia Trait

Cited by 66 publications

References 1 publication

Proxy Indicators for Identifying Iron Deficiency among Anemic Vegetarians in an Area Prevalent for Thalassemia and Hemoglobinopathies

Proxy Indicators for Identifying Iron Deficiency among Anemic Vegetarians in an Area Prevalent for Thalassemia and Hemoglobinopathies

Diagnostic value of fingerprint patterns: An explorative study on beta-thalassemia diagnosis

Screening for the beta-thalassaemia trait: hazards among populations of West African Ancestry

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