Iron deficiency and NRAMP1 polymorphisms (INT4, D543N and 3′UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population

Sahiratmadja, Edhyana; Wieringa, Frank T.; Crevel, Reinout van; Visser, Adriëtte W. de; Adnan, Iskandar; Alisjahbana, Bachti; Slagboom, P. Eline; Marzuki, Sangkot; Ottenhoff, Tom H. M.; Vosse, Esther van de; Marx, Joannes J.M.

doi:10.1017/s0007114507742691

Cited by 41 publications

(61 citation statements)

References 37 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It should be noted that anemia in tuberculosis is mainly inflammatory anemia (anemia of inflammation or AI). Interestingly, this AI often resolves with TB treatment as previously reported [4] [5] [9]. Also, depending on whether HIV is also present or not, resolution of anemia was reported after ART treatment in TB-HIV+ patients [10].…”

Section: Introductionsupporting

confidence: 67%

“…Anemia of any severity was observed in more than two-third of patients (69.5%) in the current study. This is rather a common finding during TB [4] [5], with significant frequency variability, including 67% in Gambia, 63.2% in Indonesia, 37% in Ethiopia [7], or 31.9% in South Korea [4] [5] [9]. However, the anemia in the current study seems to be at the upper end of the reported frequencies.…”

Section: Discussionmentioning

confidence: 43%

“…Also, depending on whether HIV is also present or not, resolution of anemia was reported after ART treatment in TB-HIV+ patients [10]. Of interest, patients with iron-responsive anemia (iron deficiency anemia (IDA), and multifactorial anemia (IDA + AI)) [4] [9] do not show spontaneous resolution of anemia with TB treatment. Rather, iron-responsive anemia in TB tends to recover quickly after 2 or 3 months of iron supplement in addition to TB treatment [4] [11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anemia and Hematologic Characteristics in Newly Diagnosed Pulmonary Tuberculosis Patients at Diagnosis in Kinshasa

Mulenga¹,

Kayembe²,

Kabengele³

et al. 2017

JTR

View full text Add to dashboard Cite

Context: The burden of TB in Africa tends to be exacerbated by the socio-economic situation and the high prevalence of intercurrent infections such as HIV, malaria and non-specific bacterial infections. These factors often result in anemia, making patients at high risk for anemia. Objective: We aimed to gain insights into the characteristics of anemia, hematologic variations and socio-economic status in untreated pulmonary TB patients (PTB) in Kinshasa, the Democratic Republic of Congo. Methods: We conducted a cross-sectional analysis of 200 smear-positive pulmonary TB patients (PTB) recruited at the initiation of TB treatment. Complete Blood Count, Iron profile, BMI, CRP and albuminemia were assessed. Data were analyzed using Student t or Mann Whitney tests as appropriate, and logistic regression was performed to assess the strength of associations. Results: Anemia was a regular finding in (69%). This anemia was mostly moderate (92.2%) and with iron deficiency pattern (48%). Hypoalbuminemia was observed in half of the subjects and appears to be correlated with the severity of anemia. Surprisingly, the severity of inflammation, as reflected by the CRP, was inversely correlated with the anemia. In the multivariate analysis, alcohol intake (OR: 2.38; IC 95%: 1.05 -5.38), hypoalbuminemia (OR: 1.98; IC 95%: 1.02 -3.82) and CRP rate were significantly associated with the presence of anemia among pulmonary tuberculosis at the diagnostic. Conclusion: This study demonstrates the heavy burden of the iron responsive anemia and risky life conditions in newly diagnosed TB patients, and underscores the potential usefulness of iron supplementation in the Congolese context.

show abstract

Section: Introductionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 43%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anemia and Hematologic Characteristics in Newly Diagnosed Pulmonary Tuberculosis Patients at Diagnosis in Kinshasa

Mulenga¹,

Kayembe²,

Kabengele³

et al. 2017

JTR

View full text Add to dashboard Cite

show abstract

“…On the other hand, iron deficiency causes iron-deficiency anaemia with all its associated symptoms. An optimal level of iron is needed for natural immunity against the growth of pathogens [5]. Haematological abnormalities have been associated with tuberculosis infection.…”

Section: Introductionmentioning

confidence: 99%

Altered protein and iron levels of patients with active tuberculosis in a Nigerian reference health facility

Akpan¹,

Okafor²,

Anakebe³

2017

Af J Clin Exp Micro

View full text Add to dashboard Cite

Backgound: Tuberculosis as a state of chronic inflammation impacts on haematologic functions of the body.Objectives: This study aimed at assessing iron parameters and serum protein levels of ninety tuberculosis patients aged fifteen to sixty years, enrolled from Dr Lawrence Henshaw Memorial Hospital, Calabar, Nigeria. Ninety apparently healthy individuals age and gendermatched served as control subjects.Methods: Packed cell volume, haemoglobin concentration, serum iron, total iron binding capacity, total protein, albumin and serum ferritin were determined using standard methods. Transferrin saturation, globulin concentration and albumin-globulin ratio were derived by calculation. Data were analysed using student T-test on SPSS version 20 software. Statistical significance was set at P-value less than 0.05. 175Conclusion : une réduction de l'hémoglobine, le fer sérique, capacité totale de fixation du fer et la saturation de la transferrine et la ferritine sérique en augmentation ainsi que le taux de protéines sériques modifié, se produisent dans l'infection par la tuberculose.

show abstract

“…This might explain, using the host-agent-environment (HAE) model, why 90% of people infected by Mycobacterium tuberculosis (Mtb) do not develop TB disease [12]. In the western and central parts of Indonesia, NRAMP1 gene polymorphism seems not to be related to TB susceptibility [13,14], though our previous study in the eastern region showed otherwise [15].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of the Bacillus Calmette-Guerin vaccine in an Indonesian population with D543N NRAMP1 polymorphism

Putera

Pakasi

Syahmar

et al. 2015

J Infect Dev Ctries

Self Cite

View full text Add to dashboard Cite

Introduction: Bacille Calmette-Guerin (BCG) vaccination remains a routine immunization in primary care in tuberculosis (TB)-endemic areas, though several studies found that its efficacy was inconclusive. Natural resistance-asociated machrophage protein 1 (NRAMP1) polymorphism has been shown to result in higher susceptibility to TB. Information on genetic susceptibility in populations will be useful in planning the application of the BCG vaccine. The present study explored BCG efficacy in a rural Timor population with specific NRAMP1 polymorphism in a TB-endemic region of eastern Indonesia. Methodology: A case-control study with 64 newly diagnosed pulmonary TB patients and 65 healthy controls was performed. BCG scars were examined by a physician. NRAMP1 polymorphism was evaluated using molecular methods. Results: Half of the subjects (65; 50.4%) had a clear presenting BCG scar on the upper arm, suggesting a successful BCG vaccination. Among the subjects, D543N NRAMP1 polymorphism, history of contact with TB patients, and not having a clear BCG scar on the upper arm tended to be significantly association with active TB. The significant differences were more profound when subjects were divided based on presenting BCG scar. Subjects without clear BCG scars had significant association with developing TB disease (p = 0.014). In multivariate analysis, history of previous contact with TB patients and unclear presenting BCG scar were associated with active TB (OR 9.2; 2.0-43.8 95% CI, OR 4.8; 2.1-11.0 95% CI, respectively). Conclusions: BCG vaccination in our population was effective for TB protection, especially in highly endemic areas of TB, regardless genetic susceptibility.

show abstract

Iron deficiency and NRAMP1 polymorphisms (INT4, D543N and 3′UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population

Cited by 41 publications

References 37 publications

Anemia and Hematologic Characteristics in Newly Diagnosed Pulmonary Tuberculosis Patients at Diagnosis in Kinshasa

Anemia and Hematologic Characteristics in Newly Diagnosed Pulmonary Tuberculosis Patients at Diagnosis in Kinshasa

Altered protein and iron levels of patients with active tuberculosis in a Nigerian reference health facility

Effectiveness of the Bacillus Calmette-Guerin vaccine in an Indonesian population with D543N NRAMP1 polymorphism

Contact Info

Product

Resources

About