Iron deficiency and interleukin 1 production by rat leukocytes

Helyar, Lesley; Sherman, Adria Rothman

doi:10.1093/ajcn/46.2.346

Cited by 56 publications

(15 citation statements)

References 29 publications

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“…There is some preliminary evidence in mice to suggest that iron deficiency may impair macrophage function (39). Macrophages from iron deficient mice have been shown to have impaired phagocytic activity and reduced interleukin I production (40).…”

Section: Non-specific Immunitymentioning

confidence: 99%

Iron and Immunity

Farthing

1989

Acta Paediatrica

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Farthing, M. J. G. (Department of Gastroenterology, St Bartholomew's Hospital, London, ECIA 7BE, UK). Iron and immunity. Review of animal and human studies concerning the impact of iron deficiency on immune function in vivo indicates that in many instances there is no firm consensus of opinion as to the relationship between iron status and immunity. One major problem with almost all human studies is that other micro‐ and macronutrient deficiencies are inadequately controlled for and thus it is often unclear as to whether reported abnormalities of immune function can be attributed specifically to iron deficiency. Even when abnormalities of immune function have been detected it is often uncertain as to the biological and clinical relevance that these may have for the host. Within these restraints the available studies suggest that iron deficiency may at least contribute to impaired T lymphocyte function as judged by DTH responses in skin and impaired mitogen‐induced proliferation. As in protein energy malnutrition, humoral immunity is largely spared in humans, the balance of evidence suggesting that immunoglobulin production and function is normal, as are serum concentrations of complement. The only other abnormality of non‐specific immunity which has been reported consistently to be abnormal is that of reduced bactericidal activity of polymorphonuclear leucocytes. The clinical relevance of these abnormalities remains to be established. There is, however, no evidence to suggest that individuals with iron deficiency suffer the devastating infective complications of the well defined immunodeficiency syndromes either congenital or acquired. It seems likely therefore that despite the fundamental importance of iron in maintaining the integrity of immune function, humans can tolerate the extremes of deficiency and excess and survive in a relatively healthy state.

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Section: Non-specific Immunitymentioning

confidence: 99%

Iron and Immunity

Farthing

1989

Acta Paediatrica

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“…At the systemic level, studies in experimental animals and humans have shown that administration of TNF-α suppresses serum iron concentration [25-27]. Not only does inflammation affect iron metabolism, but iron status itself may modulate the production of inflammatory cytokines [28-30]. Iron deficiency anemia in infants was reported to increase lipopolysaccharide-induced production of tumor necrosis factor-α by peripheral blood mononuclear cells [29].…”

Section: Introductionmentioning

confidence: 99%

Ferroportin (SLC40A1) Q248H mutation is associated with lower circulating plasma tumor necrosis factor-α and macrophage migration inhibitory factor concentrations in African children

Kasvosve

Debebe

Nekhai

2010

Clinica Chimica Acta

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“…Maintenance of cellular iron homeostasis is not only a general prerequisite for the growth and proliferation of all cells but is also of central importance for the regulation of the immune function. Iron status has been reported to modulate cytokine secretion [3, 4]. In general, iron has been reported to direct the immune response towards a Th2 response pattern [5, 6] that is believed to be unfavourable for the killing of many intracellular pathogens.…”

Section: Introductionmentioning

confidence: 99%

Cytokine mRNA Expression and Iron Status in Children Living in a Malaria Endemic Area

et al. 2005

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Iron deficiency has been reported to affect both malaria pathogenesis and cellmediated immune responses; however, it is unclear whether the protection afforded by iron deficiency is mediated through direct effects on the parasite, through immune effector functions or through both. We have determined cytokine mRNA expression levels in 59 children living in a malaria endemic area on the coast of Kenya who we selected on the basis of their biochemical iron status. Real-time quantitative reverse transcriptase polymerase chain reaction analysis of cytokine mRNA levels of peripheral blood mononuclear cells (PBMC) obtained from these children showed an association between interleukin-4 (IL-4) mRNA levels and all the biochemical indices of iron that we measured. Furthermore, IL-10 mRNA was higher in parasite blood smearpositive children than in blood smear-negative children irrespective of their iron status. This study suggests that IL-4 expression by PBMC may be affected by iron status.

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Iron deficiency and interleukin 1 production by rat leukocytes

Cited by 56 publications

References 29 publications

Iron and Immunity

Iron and Immunity

Ferroportin (SLC40A1) Q248H mutation is associated with lower circulating plasma tumor necrosis factor-α and macrophage migration inhibitory factor concentrations in African children

Cytokine mRNA Expression and Iron Status in Children Living in a Malaria Endemic Area

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