Iron deficiency anaemia in older people: investigation, management and treatment

Mukhopadhyay, Diptarup; Mohanaruban, K

doi:10.1093/ageing/31.2.87

Cited by 49 publications

(46 citation statements)

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“…In a study carried out in England, it was reported that its frequency was between 3.5-5.3% [23]. Malabsroption and iron deficiency anemia depending on menorrhagia occurring as a result of various hormonal instability are observed in hypothroidism.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of anemia in subclinical and overt hypothyroid patients

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Characteristics of anemia in subclinical and overt hypothyroid patients

et al. 2012

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“…As an acute phase reactant, serum ferritin increases in infections [12], rheumatoid arthritis [9], liver disease [10], cancer, and other inflammatory conditions. Ferritin level also rises with aging [7] and in the presence of other concomitant medical problems such as hypertension, chronic renal failure, chronic obstructive pulmonary disease, and diabetes [6]. In a study of 101 anemic patients, using bone marrow hemosiderin as the reference standard, a serum ferritin level < 100 ng/dL was optimal for determining iron deficiency, with a sensitivity of 65%, a specificity of 96%, a positive predictive value of 92%, and a negative predictive value of 79% [6].…”

Section: Discussionmentioning

confidence: 99%

“…Published series of gastrointestinal endoscopy in patients with iron deficiency anemia vary in the criteria they use to diagnose the iron deficiency, but most studies use ferritin below 20-50 ng/mL [1][2][3][4][5]. However, studies using bone marrow hemosiderin as the gold standard have shown that in older patients and/or in patients with comorbidites, iron deficiency anemia is often present despite normal levels of ferritin [6][7][8][9][10]. In a study of 101 anemic veterans who underwent bone marrow examination with hemosiderin stain, the mean ferritin in irondeficient patients was 53 ng/mL, with a range of 9-518 ng/mL [6].…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal endoscopic findings in men with unexplained anemia and low normal ferritin values

et al. 2006

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Background: Most practice guidelines recommend endoscopic evaluation of the gastrointestinal (GI) tract in men and postmenopausal women with anemia and a serum ferritin less than 20-40 ng/ml. The diagnostic yield of endoscopy in patients with anemia, no GI symptoms or signs, and low normal ferritin is not known. Objective: The aim of this study was to investigate the yield of upper and lower GI endoscopic evaluations in anemic patients with ferritin levels between 40 and 100 ng/ml. Design: A retrospective review of patients' charts was conducted. Subjects and methods: Patients at the Veterans Affairs Connecticut Healthcare System who underwent GI endoscopic evaluation for the sole indication of anemia and ferritin in the low normal range (40-100 ng/ml) were included in this study. Measurements: Incidence of pathology of the upper and lower GI tract was determined. Results: We identified 54 male patients who had a ferritin level of 40-100 ng/ml and no GI symptoms or known GI bleeding. Upper GI findings (malignancy, peptic ulcers, Helicobacter pylori gastritis, arteriovenous malformations) were found in 14/47 cases (30%). Lower gastrointestinal findings, including large tubular adenomas and arteriovenous malformation, were identified in 3/53 cases (6.7%). Conclusion: Our study supports GI endoscopy in anemic patients with ferritin between 40 and 100 ng/ml, even in the absence of GI symptoms or documented bleeding. Am. J. Hematol. 81:324-327, 2006. V V C 2006 Wiley-Liss, Inc.

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“…In order to characterize the type of anemia and formulate a differential diagnosis, the work-up should include physical exams and laboratory tests, such as evaluations of hematocrit, hemoglobin and red blood cell indices. The red blood cell indices should include the cell count, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and red cell distribution width (RDW) 9 .…”

Section: Introductionmentioning

confidence: 99%

Study of Anaemia in Correlation with Hematological Parameters among Adults in a Tertiary Care Centre of North-East India

Kouli¹,

Pegu²,

Teronpi³

et al. 2016

IJMRP

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Objectives: The aims of this study are to evaluate the hematological parameters, type and severity of spectrum of anemia in known anemic cases in adult age group. Methods: This study was carried out in the Department of Pathology, in a tertiary health care center on 1330 cases. The cases were from both indoor and outdoor patients admitted in various wards. The samples for test were collected in EDTA tube. The samples were run in hematology cell counter Sysmex XS-800i for hematology indices and other parameters. Results: The overall prevalence of anemia was 71.58%. Moderate degree of Anemia was the most common followed by mild degree. Anemia was present in 39.92% of men and in 60.08% of women. Microcytic hypochromic anemia is the most common type of anemia in adult, more in reproductive age group indicating iron deficiency as the main cause. It was followed by normocytic normochromic anemia both in men and women. Conclusion: Anemia is a widespread public health problem associated with an increased risk of morbidity and mortality, especially in pregnant women and young children. The prevalence of anemia increases with age and is associated with race, chronic diseases, nutritional deficiencies and other conditions such as infection. A diagnosis of anemia warrants adequate clinical attention, to find out the cause, type, severity and this forms the basis for treatment of anemia. RBC indices provide important guidelines for diagnosis, classification and monitoring the treatment of anemia .

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Iron deficiency anaemia in older people: investigation, management and treatment

Cited by 49 publications

References 0 publications

Characteristics of anemia in subclinical and overt hypothyroid patients

Characteristics of anemia in subclinical and overt hypothyroid patients

Gastrointestinal endoscopic findings in men with unexplained anemia and low normal ferritin values

Study of Anaemia in Correlation with Hematological Parameters among Adults in a Tertiary Care Centre of North-East India

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