Iron deficiency affects oxygen transport and activates HIF1 signaling pathway to regulate phenotypic transformation of VSMC in aortic dissection
Yuanyang Chen,
Xu Li,
Zhiwei Wang
et al.
Abstract:Background
Aortic dissection (AD) is a macrovascular disease which is pathologically characterized by aortic media degeneration.This experiment aims to explore how iron deficiency (ID) affects the function of vascular smooth muscle cell (VSMC) and participates in the occurrence and development of AD by regulating gene expression.
Methods
The relationship between iron and AD was proved by Western-blot (WB) and immunostaining experiments in human and… Show more
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