Iron chelation in the biological activity of curcumin

Jiao, Yan; Wilkinson, John; Pietsch, Emma; Buss, Joan L.; Wang, Wei; Planalp, Roy P.; Torti, Frank M.; Torti, Suzy V.

doi:10.1016/j.freeradbiomed.2005.11.003

Cited by 192 publications

(154 citation statements)

References 38 publications

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“…It can be expected that polyphenols or other honey compounds could hinder or block the entry of this cavity. Jiao et al (2006) showed that curcuminoids could act as iron chelators, and it cannot be excluded that such a chelating activity could also be possible with some honey components. Further studies are needed to confirm this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Effect of honey on purified equine myeloperoxidase activity and superoxide radical production in activated Polymorphonuclear neutrophils

Saad

Benbarek

Franck

et al. 2015

Frontiers in Life Science

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Three Algerian honey samples (nectar honey, mixed honey and honeydew honey) were analysed for their total phenolic content (TPC) using the Folin-Ciocalteu reagent and total flavonoid content (TFC) by the aluminium chloride method. The antioxidant activity was tested both against reactive oxygen species (ROS) produced by phorbol 12-myristate 13-acetate (PMA)-stimulated equine polymorphonuclear neutrophils (PMNs) and on purified equine myeloperoxidase (MPO) enzyme activity. The ROS production by stimulated PMNs was measured by lucigenin-enhanced chemiluminescence. Specific immunological extraction followed by enzymatic detection (SIEFED) was used to measure specifically the activity of equine MPO. Nectar honey, mixed honey and honeydew honey had TPCs of 59.52 ± 1.31, 68.36 ± 1.20 and 122.76 ± 4.20 mg gallic acid equivalents (GAE)/100 g honey, respectively (mean ± SD). As for the TPC, the highest TFC was observed for honeydew honey [20.55 ± 0.72 mg catechine equivalents (CE)/100 mg honey], followed by mixed honey (7.47 ± 0.07 CE/100 mg honey) and nectar honey (4.80 ± 0.08 CE/100 mg honey). All the tested honeys displayed a dosedependent inhibitory effect on the oxidant activities of PMNs. By the SIEFED technique, it was shown that most of the honeys interact directly with MPO: the light honeys (nectar honey and mixed honey) were inhibitors of MPO activity, while the dark honey had less inhibiting effect and even behaved as an enhancer of MPO activity at high concentrations.

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Section: Discussionmentioning

confidence: 99%

Effect of honey on purified equine myeloperoxidase activity and superoxide radical production in activated Polymorphonuclear neutrophils

Saad

Benbarek

Franck

et al. 2015

Frontiers in Life Science

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“…Although iron depletion and the subsequent inhibition of RR were traditionally considered as the mechanisms of the growth inhibitory effects of iron chelators, recent evidence suggests the involvement of many other genes, molecules and signaling pathways (154). Moreover, iron chelators could act as chemo-preventive agents by inhibiting participation of iron in the Fenton reaction and other oxidative stress pathways induced by iron (155).…”

Section: Therapeutic Effects Of Iron Defficiencymentioning

confidence: 99%

“…Curcumin suppresses activation of NF-κB and COX2, changes AP1 complexes, inhibits Akt, stimulates cytoprotective phase II enzymes including glutamate-cysteine ligase, isoforms of glutathione S-transferase, heme oxygenase and NAD(P)H quinone oxidoreductase1. Furthermore, curcumin is an antioxidant and free radical remover (155) and demonstrates iron chelation properties in vitro, particularly for Fe 3+ (153,155,158) which may lead to curcumin's antioxidant and antiproliferative activities. In an experimental study curcumin was protective towards nigral dopaminergic neurons against 6-hydroxydopamine, which could be attributed to its iron-chelating properties (159).…”

Section: Therapeutic Effects Of Iron Defficiencymentioning

confidence: 99%

The Dual Nature of Iron in Relation to Cancer: A Review

et al. 2016

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Background: Although iron is essential for all cells, it could be potentially hazardous. This is mostly due to iron participation in oxidation-reduction reactions. In terms of cancer risk, the role of both iron deficiency and overload can be studied in two directions, protective or therapeutic effects, and carcinogenic effects. Materials and Methods:PubMed, Science direct, Ovid, Proquest, Medline, and Google scholar databases were used to obtain articles identified by using the key words "Iron", "Iron deficiency", "Iron overload", "Cancer", and "Neoplasm" without any time limit. The relevance of studies was identified by reviewing the titles and the abstracts. 185 articles published in English, including experimental, observational, molecular and cellular studies were reviewed. Results and Conclusion:Considering the dual nature of iron, maintaining an optimal iron level in the body is important. This can be achieved when regulatory mechanisms of body iron level work properly and the amount of iron input is within the physiological range. Current evidence generally supports this possibility that higher animal-derived (heme) iron may increase the risk of some cancers. The release of iron or nitrosyl heme from iron complexes during some processing of meat may increase production of cancer promoter lipoperoxides. On the other hand, use of iron chelation or iron mediated oxidative assault for the treatment or prevention of cancer appears to be promising; but further research is required. Considering this background, this article reviews the literature and evidence, focusing on the role of iron overload and deficiency in developing and treatment of various cancers.

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“…Treatment with iron MCGA3 activates p21 and enhances UVA-mediated apoptosis M-H Kweon et al chelators mimics oxygen deprivation and hypoxic induction of HIF-1a, which activates transcription of transferring receptor 1 (TfR1) (Bianchi et al, 1999). To confirm iron chelation by MCGA3, we determined changes in the expression pattern of proteins, ferritin and TfR1, that are regulated by intracellular iron content (Jiao et al, 2006), in cells treated with MCGA3. As shown in Figure 8a, the level of ferritin was found to be decreased by MCGA3 treatment, which is evident at 8 h after treatment, whereas TfR1 protein level was more rapidly elevated by MCGA3 treatment, which is evident at 2 h and gradually increased in a timedependent manner.…”

Section: Mcga3 Inhibits Uva-initiated Survival Signalsmentioning

confidence: 99%

A novel antioxidant 3-O-Caffeoyl-1-methylquinic acid enhances ultraviolet A-mediated apoptosis in immortalized HaCaT keratinocytes via Sp1-dependent transcriptional activation of p21WAF1/Cip1

et al. 2006

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It has become clear that ultraviolet A (UVA) radiation from the solar spectrum is a major environmental challenge to the skin. This necessitates developing novel mechanism-based agents capable of ameliorating UVAinduced effects in the skin. We recently described a novel antioxidant, 3-O-Caffeoyl-1-methylquinic acid (MCGA3) from leaves of bamboo. Here, we investigated the photochemopreventive effects of MCGA3 against UVAmediated apoptosis in immortalized HaCaT keratinocytes. Pretreatment of MCGA3 rendered cells more sensitive to subsequent UVA irradiation-induced apoptosis as well as completely reversed UVA-induced sustained phosphorylation of extracellular signal-regulated kinase 1/2 and protein kinase Ca, downregulation of p21, and reactive oxygen species generation. Interestingly, MCGA3 itself effectively induced p21 protein and mRNA levels. Silencing of p21 by RNA interference revealed a pivotal role of p21 in generating G 1 -S arrest and in enhancing UVA-mediated apoptosis. Transcriptional activation of p21 by MCGA3 was mediated through the proximal region of multiple Sp1 sites regardless of p53-binding site in p21 promoter, and this effect was augmented by desferroioxamine, an iron chelating agent. Additional studies suggested that iron chelation-driven hypoxia by MCGA3 may function in activation of p21. MCGA3 could be a useful agent to prevent photocarcinogenesis via apoptotic elimination of p53 mutant and DNA-repair defective cells caused by UVA radiation.

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Iron chelation in the biological activity of curcumin

Cited by 192 publications

References 38 publications

Effect of honey on purified equine myeloperoxidase activity and superoxide radical production in activated Polymorphonuclear neutrophils

Effect of honey on purified equine myeloperoxidase activity and superoxide radical production in activated Polymorphonuclear neutrophils

The Dual Nature of Iron in Relation to Cancer: A Review

A novel antioxidant 3-O-Caffeoyl-1-methylquinic acid enhances ultraviolet A-mediated apoptosis in immortalized HaCaT keratinocytes via Sp1-dependent transcriptional activation of p21WAF1/Cip1

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