Iron-Chelating Therapies in a Transfusion-Dependent Thalassaemia Population in Thailand

Luangasanatip, Nantasit; Chaiyakunapruk, Nathorn; Upakdee, Nilawan; Wong, Peerapon

doi:10.2165/11587120-000000000-00000

Cited by 26 publications

(39 citation statements)

References 23 publications

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“…Findings of this study support the view long held by health economists [22] and more recently by leading social scientists that introducing a health intervention does not, on its own, guarantee acceptance by communities. In the case of a vaccine, acceptance may depend on a number of factors that, if not addressed, may result in suboptimal immunization coverage [8,10,14,23-26].…”

Section: Discussionsupporting

confidence: 84%

Community perceptions of malaria and vaccines in the South Coast and Busia regions of Kenya

Ojakaa

Ofware

Machira

et al. 2011

Malar J

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BackgroundMalaria is a leading cause of morbidity and mortality in children younger than 5 years in Kenya. Within the context of planning for a vaccine to be used alongside existing malaria control methods, this study explores sociocultural and health communications issues among individuals who are responsible for or influence decisions on childhood vaccination at the community level.MethodsThis qualitative study was conducted in two malaria-endemic regions of Kenya--South Coast and Busia. Participant selection was purposive and criterion based. A total of 20 focus group discussions, 22 in-depth interviews, and 18 exit interviews were conducted.ResultsParticipants understand that malaria is a serious problem that no single tool can defeat. Communities would welcome a malaria vaccine, although they would have questions and concerns about the intervention. While support for local child immunization programs exists, limited understanding about vaccines and what they do is evident among younger and older people, particularly men. Even as health care providers are frustrated when parents do not have their children vaccinated, some parents have concerns about access to and the quality of vaccination services. Some women, including older mothers and those less economically privileged, see themselves as the focus of health workers' negative comments associated with either their parenting choices or their children's appearance. In general, parents and caregivers weigh several factors--such as personal opportunity costs, resource constraints, and perceived benefits--when deciding whether or not to have their children vaccinated, and the decision often is influenced by a network of people, including community leaders and health workers.ConclusionsThe study raises issues that should inform a communications strategy and guide policy decisions within Kenya on eventual malaria vaccine introduction. Unlike the current practice, where health education on child welfare and immunization focuses on women, the communications strategy should equally target men and women in ways that are appropriate for each gender. It should involve influential community members and provide needed information and reassurances about immunization. Efforts also should be made to address concerns about the quality of immunization services--including health workers' interpersonal communication skills.

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Section: Discussionsupporting

confidence: 84%

Community perceptions of malaria and vaccines in the South Coast and Busia regions of Kenya

Ojakaa

Ofware

Machira

et al. 2011

Malar J

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“…The utility of sequelae derived from the systematic review [32] was the only one parameter that influenced the ICER in the model. However, the ICER still falls within the acceptable threshold and it is important to note that borrowing utility value from the literature is not an uncommon practice [43].…”

Section: Discussionmentioning

confidence: 99%

Cost-effectiveness of pharmacist-participated warfarin therapy management in Thailand

Saokaew

Permsuwan

Chaiyakunapruk

et al. 2013

Thrombosis Research

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“…Therefore, it is likely that the assumption of DFP having equivalent or superior efficacy to DFX is a reasonable one. This analysis used a lifetime model to assess DFO, DFP and DFX monotherapies in Thailand, where thalassemia is prevalent and places significant demands on the healthcare system [38]. The model is simpler than those in other analyses because it assumes no differences in efficacy across all products, and does not incorporate AE-related mortality.…”

Section: Keshtkaran Et Al Transfusion 2013mentioning

confidence: 99%

Cost-utility of chelators in transfusion-dependent β-thalassemia major patients: a review of the pharmacoeconomic literature

Lee

Riedemann²,

Tricta³

2014

Expert Review of Pharmacoeconomics & Outcomes Research

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In the inherited hematologic disorder β-thalassemia major, patients receive regular, lifelong blood transfusions, which carry excess iron that the body is unable to eliminate. Chelation therapy (deferoxamine, deferiprone, deferasirox or deferoxamine-deferiprone combination) is required to reduce iron accumulation in target organs and the associated morbidity and mortality. Each chelation regimen has a distinct safety/efficacy profile and particular costs associated with its use. This review aims to provide an overview of published cost-utility analyses of currently used chelation regimens, and to comment on the potential relevance of their findings in the USA market, where deferiprone has recently been introduced.

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Iron-Chelating Therapies in a Transfusion-Dependent Thalassaemia Population in Thailand

Cited by 26 publications

References 23 publications

Community perceptions of malaria and vaccines in the South Coast and Busia regions of Kenya

Community perceptions of malaria and vaccines in the South Coast and Busia regions of Kenya

Cost-effectiveness of pharmacist-participated warfarin therapy management in Thailand

Cost-utility of chelators in transfusion-dependent β-thalassemia major patients: a review of the pharmacoeconomic literature

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