Iron chelated melanin-like nanoparticles for tumor-associated macrophage repolarization and cancer therapy

Rong, Lei; Zhang, Yong; Li, Weishuo; Su, Zhigui; Fadhil, Jaafar Imad; Zhang, Can

doi:10.1016/j.biomaterials.2019.119515

Cited by 133 publications

(90 citation statements)

References 32 publications

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“…Indeed, the Al 2 O 3 contained within the NP, together with a co-administered widely used, inexpensive adjuvant, CpG, effectively triggered robust cell-mediated immune responses that could help eliminate the residual tumor cells and reduce the risk of tumor recurrence. In another case, Rong et al developed an iron chelated MNP-based therapeutic agent to counteract the immunosuppressive tumor microenvironment[180]. Tumor-associated macrophages (TAMs), which are actively recruited in tumors, are one of the main drivers of this immunosuppression.…”

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confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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Bioinspired nanomaterials are ideal components for nanomedicine, by virtue of their expected biocompatibility or even complete lack of toxicity. Natural and artificial melanin-based nanoparticles (MNP), including polydopamine nanoparticles (PDA NP), excel for their extraordinary combination of additional optical, electronic, chemical, photophysical, and photochemical properties. Thanks to these features, melanin plays an important multifunctional role in the design of new platforms for nanomedicine where this material works not only as a mechanical support or scaffold, but as an active component for imaging, even multimodal, and simple or synergistic therapy. The number of examples of bio-applications of MNP increased dramatically in the last decade. Here, we review the most recent ones, focusing on the multiplicity of functions that melanin performs in theranostics platforms with increasing complexity. For the sake of clarity, we start analyzing briefly the main properties of melanin and its derivative as well as main natural sources and synthetic methods, moving to imaging application from mono-modal (fluorescence, photoacoustic, and magnetic resonance) to multi-modal, and then to mono-therapy (drug delivery, anti-oxidant, photothermal, and photodynamic), and finally to theranostics and synergistic therapies, including gene- and immuno- in combination to photothermal and photodynamic. Nanomedicine aims not only at the treatment of diseases, but also to their prevention, and melanin in nature performs a protective action, in the form of nanopigment, against UV-Vis radiations and oxidants. With these functions being at the border between nanomedicine and cosmetics nanotechnology, recently examples of applications of artificial MNP in cosmetics are increasing, paving the road to the birth of the new science of nanocosmetics. In the last part of this review, we summarize and discuss these important recent results that establish evidence of the interconnection between nanomedicine and cosmetics nanotechnology.

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confidence: 99%

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

et al. 2020

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“…Cytotoxicity, apoptotic activity, and cell proliferation tests were performed to discover whether our Fe 3 O 4 nanoparticles had appropriate biocompatibility for future biomedical applications. As aforementioned, many studies have reported results using Fe for biomedical applications [30,31,32]. However, Fe ions released from Fe nanoparticles often cause damage and death of animal cells due to excess generation of reactive oxygen species [33,34,35,36].…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Sub 3 nm-Sized Uniform Magnetite Nanoparticles Using Reverse Micelle Method for Biomedical Application

et al. 2019

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We report a synthetic method for small and uniform Fe3O4 (magnetite) nanoparticles under mild conditions. Spherical sub-3 nm-sized magnetite nanoparticles were prepared via reverse micelles composed of oleylamine, F127, xylene, and water for the reaction of iron(III) stearate with hydrazine at a reaction temperature of 90 °C in air atmosphere. These synthesized magnetite nanoparticles exhibited good size uniformity. By controlling experimental conditions, we could easily control both size and size uniformity of these magnetite nanoparticles. We further investigated whether Fe3O4 could be used in biomedical applications. Cytotoxicity of Fe3O4 was evaluated with human adipose-derived stem cells (hADSCs). Our results showed that the number of hADSCs did not significantly decrease when these cells were treated with Fe3O4 nanoparticles at a concentration of up to 9 μg/mL. Apoptotic activity and cell proliferation of hADSCs treated with Fe3O4 nanoparticles were similar to those of hADSCs without any treatment. This novel method could be used for synthesizing uniform and biocompatible Fe3O4 nanoparticles with further biomedical applications.

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“…In a corresponding example demonstrated by Zhang et al., Fe 3+ ions were introduced to PEGylated polydopamine (PDA) to fabricate iron‐chelated melanin‐like nanocomposites (Fe@PDA‐PEG). [ 115 ] As shown in Figure , Fe@PDA‐PEG could achieve exceptional PTT and cause the release of TAAs. Furthermore, the TAMs were repolarized to the M1 phenotype robustly due to iron ion‐overload.…”

Section: Htt‐based Multipronged Approaches In Synergistic Immunotherapymentioning

confidence: 99%

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

et al. 2020

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Figure 3. a) Schematic illustration of the PTT-assisted immunotherapy. b) PD-L1 expression on 4T1 tumor cells after different treatments. c) Flow cytometric examination of the intratumor infiltration of CD4 + and CD8 + T cells. d,e) The primary and distal tumor growth curves of 4T1 tumor-bearing mice. f) Quantification of pulmonary metastasis nodules in different groups of 4T1 tumor-bearing mice. g) The tumor growth curves of B16F10-bearing mice model (*p < 0.05, **p < 0.01, ***p < 0.001). Reproduced with permission. [52] Copyright 2019, Nature Research.

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Iron chelated melanin-like nanoparticles for tumor-associated macrophage repolarization and cancer therapy

Cited by 133 publications

References 32 publications

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics

Synthesis of Sub 3 nm-Sized Uniform Magnetite Nanoparticles Using Reverse Micelle Method for Biomedical Application

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

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