Iron‐Catalyzed Nitrene Insertion of CH Bonds

Abstract

Nitrene insertion of CH bonds represents a powerful synthetic method to form nitrogen‐containing organic compounds. This article summarized recent development of iron‐catalyzed nitrene insertion of CH bonds for the construction of CN bonds and organized by the types of nitrene precursors, including iminoiodanes, organic azides, hydroxylamine derivatives, sulfonamides, etc. Important examples and breakthroughs in this field are highlighted, and the current mechanistic understandings of the formation of iron‐nitrenoid species and the catalytic cycles are discussed. Additionally, the synthetic application of this chemistry is also included.