Iron‐Catalyzed, Iminyl Radical‐Triggered Cascade 1,5‐Hydrogen Atom Transfer/(5+2) or (5+1) Annulation: Oxime as a Five‐Atom Assembling Unit

Abstract

By integration of iminyl radical-triggered 1,5-hydrogen atom transfer and (5+ +2) or (5+ +1) annulation processes, aseries of structurally novel and interesting azepine and spirotetrahydropyridine derivatives have been successfully prepared in moderate to good yields.T his method utilizes FeCl 2 as the catalyst and readily available oximes as five-atom units,w hile showcasing broad substrate scope and good functional group compatibility.The annulation products can be easily converted into many valuable compounds.M oreover,D FT calculation studies are performed to providesome insights into the possible reaction mechanisms for the (5+ +2) and (5+ +1) annulations.