Iron‐Catalyzed Direct Synthesis of Amides from Methylarenes

Abstract

An efficient, green and first catalytic process hasb een developed for the direct synthesiso f amides from readilya vailablep etroleum by-products (methylarenes) anda mines using an iron catalyst. In this newc atalytic reaction, the methylg roup of the methylarene is oxidized to the corresponding aldehyde through non-directed C (sp 3 ) À Ho xidation followed by its oxidative amidation with N-chloroamine,y ielding the carboxylic amide.O xidation with an iron catalyst, tert-butyl hydroperoxide (TBHP) as sole oxidant, the synthesiso fa mides under mild reaction conditions and the utilizationo fm ethylarenes as starting material maket his methodology novel and environmentally benign.

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