Iron-Catalyzed Annulation of 2-Aminobenzaldehydes with Iodonium Ylides: A Mild and General Route for the Synthesis of Acridinone Derivatives

Abstract

An inexpensive iron-catalyzed annulation of 2-aminobenzaldehydes with iodonium ylides for the synthesis of acridinone derivatives was reported. A library of biologically relevant 3,4-dihydropyridine-1-one scaffold was synthesized by the reaction of corresponding 2-amino benzaldehyde and iodonium ylides under mild reaction conditions in a green solvent. The reaction tolerates various alkyl, aryl and halogenated substrates and affords the desired product in moderate to good yields. The reported reaction has an inexpensive catalytic system, mild reaction conditions, easily accessible substrates and the use of green solvents.