Iron-catalysed, general and operationally simple formal hydrogenation using Fe(OTf)₃ and NaBH₄

Abstract

An operationally simple and environmentally benign formal hydrogenation protocol has been developed using a highly abundant iron(iii) salt and an inexpensive, bench stable, stoichiometric reductant, NaBH4, in ethanol, under ambient conditions.

Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins

“…393 This work was developed based on the precedent of Kano 64,392 and Boger, 25,26,81, who reported methods for the hydrofunctionalization of olefins with iron complexes and sodium borohydride reductants. The reaction converts terminal alkenes to the corresponding alkane.…”

Iron-catalysed allylation–hydrogenation sequences as masked alkyl–alkyl cross-couplings

“…31 There are a handful of powerful homogeneous iron catalysts based on pincer-type ligands 32,33 and heterogeneous catalysts derived from the reduction of iron salts with organometallic or hydride reagents. [34][35][36][37] With regard to the latter catalyst class, we surmised that the iron catalyst that formed under the conditions of the cross-coupling reaction with the organomagnesium halide might also be competent in the subsequent alkene hydrogenation (Scheme 1, bottom right). 15…”

Iron‐Catalysed Hydrofunctionalisation of Alkenes and Alkynes

“…The scope of the reaction was demonstrated with a limited range of styrene and phenylacetylene derivatives. [65] Products arising from formal hydrogenation and reductive dimerisation were obtained in each case.…”