Iron bond bovine lactoferrin for the treatment of cancers and anemia associated with cancer cachexia

Aboda, Ayman; Taha, Wafa; Attia, Iman; Gad, Ahmed; Mostafa, Mamdouh Mahmoud; Abdelwadod, Mohammed Abdelfattah; Mohsen, Mahmoud; Kanwar, Rupinder K.; Kanwar, Jagat R.

doi:10.1016/b978-0-12-819666-3.00008-0

Cited by 6 publications

(2 citation statements)

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“…Table S1 lists some of the Lf-based products available in the pharmaceutical market. Many studies and clinical trials have demonstrated the safety and tolerability of orally administered rhLf in treatment of non-small cell lung cancer and renal cell carcinoma [ 5 , 75 ]. We have summarized the most important outcomes of the clinical trials based on Lf products for various applications ( Table S2 ).…”

Section: Clinical Trials and Future Perspectivesmentioning

confidence: 99%

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Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand

et al. 2020

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Recent progress in protein-based nanomedicine, inspired by the success of Abraxane® albumin-paclitaxel nanoparticles, have resulted in novel therapeutics used for treatment of challenging diseases like cancer and viral infections. However, absence of specific drug targeting, poor pharmacokinetics, premature drug release, and off-target toxicity are still formidable challenges in the clinic. Therefore, alternative protein-based nanomedicines were developed to overcome those challenges. In this regard, lactoferrin (Lf), a glycoprotein of transferrin family, offers a promising biodegradable well tolerated material that could be exploited both as an active therapeutic and drug nanocarrier. This review highlights the major pharmacological actions of Lf including anti-cancer, antiviral, and immunomodulatory actions. Delivery technologies of Lf to improve its pries and enhance its efficacy were also reviewed. Moreover, different nano-engineering strategies used for fabrication of drug-loaded Lf nanocarriers were discussed. In addition, the use of Lf for functionalization of drug nanocarriers with emphasis on tumor-targeted drug delivery was illustrated. Besides its wide application in oncology nano-therapeutics, we discussed the recent advances of Lf-based nanocarriers as efficient platforms for delivery of anti-parkinsonian, anti-Alzheimer, anti-viral drugs, immunomodulatory and bone engineering applications.

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Section: Clinical Trials and Future Perspectivesmentioning

confidence: 99%

“…Since Lf is a natural protein present in the milk, the chances of eliciting any adverse immune reaction would be minimal [ 5 ]. Primarily, the particles fabricated based on Lf protein prepared by mild methods that do not involve any chemical reactions.…”

Section: Introductionmentioning

confidence: 99%