Iron‐Based Multi‐Catalysis: Eco‐Compatible Alternative for Complex Molecules Synthesis

Abstract

Scheme3.SynergisticGrignard reagents addition on alkynes. Scheme4.Synergisticcross-coupling between aryl-iodidesa nd amines. Scheme5.SynergisticFe ÀCu or FeÀTi intermolecular cross-coupling reactions.

Multicatalytic Approach to One-Pot Stereoselective Synthesis of Secondary Benzylic Alcohols

“…Because the bulk of organic solvents is used for isolation and purification of synthetic intermediates, rather than as the medium of the actual chemical reactions, procedures that execute multiple synthetic steps in a one-pot fashion are advantageous from the efficiency standpoint. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] The economy of one-pot synthesis 21 that connects stoichiometric and catalytic reactions, with or without limited intermediary work-up, proved highly beneficial for the synthesis of complex molecules, 22 including natural products and pharmaceuticals. [23][24][25] However, the development of one-pot protocols with multiple transition-metal catalyzed reactions operating in one vessel remains a challenge.…”

Challenges and Opportunities in Multicatalysis

“…Catalytic transformations are typically constrained to one catalyst enabling a single reaction. However, the field continues evolving in complexity to further increase its potential. − Recently, there has been growing interest in developing multicatalytic systems, which are inspired by the complexity of catalytic reactions occurring in nature. , Such efforts are further driven by remarkable characteristics of biosynthesis, that is, excellent selectivity, high yields, and material efficiency when producing complex molecules directly without any isolation of intermediates. However, to develop such multicatalytic systems, major challenges need to be addressed, including incompatibility between multiple catalysts or reagents, precise ordering of all individual processes, and operation of all reactions under a single set of conditions.…”

Variable structure diversification by multicatalysis: the case of alcohols

“…11 Recently, inspired by biological systems, a trend has emerged in the field of catalysis, which involves using multiple catalysts to execute several transformations in one vessel, increasing the general efficiency and creating new selective transformations. [12][13][14][15][16][17][18][19][20][21][22] For instance, multicatalysis proved to enable modifying molecules at their inherently poorly reactive sites thanks to the cooperativity between two orthogonal reactions operating in a one-pot. Also, merging multiple reactions into a one-step process makes the overall transformations more time-efficient, economical, and easier to execute for an experimenter.…”