Iron Balances in Infant Nutrition

Schulz-Lell, G.; Buss, R; Oldigs, H. D.; Dörner, Klaus; Schaub, J.

doi:10.1111/j.1651-2227.1987.tb10525.x

Cited by 31 publications

(18 citation statements)

References 22 publications

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“…A 14-day period may be considered an adequate equilibration period that allows gastrointestinal clearance of unabsorbed minerals from the previous diet [25]. The balance comprised three 24-h urine and faeces collections at the end of each 14-day dietary treatment [26]. In total 24-h urine samples were collected on acidified recipients, beginning with the second voiding of the day and finishing with the first voiding of the following day, and the volume from each daily sample was measured.…”

Section: Subjects Diets and Study Designmentioning

confidence: 99%

Intake of Maillard reaction products reduces iron bioavailability in male adolescents

Garcı́a¹,

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Delgado-Andrade

et al. 2009

Molecular Nutrition Food Res

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The effects of diets with different Maillard reaction products (MRPs) content on biological iron utilization were compared using in vitro/in vivo assays. Diets were rich (brown diet, BD) or poor (white diet) in MRP. In vitro studies included iron solubility after in vitro digestion of diets and iron transport across Caco-2 cells. In the human assay 18 healthy adolescent males (11-14 years) participated in a 2-wk randomized two-period crossover trial. Subjects collected urine and faeces on the last 3 days of each dietary period, and fasting blood samples were obtained after periods. In vitro dietary iron availability was significantly lower with the BD than the white diet (9.52 and 12.92%, respectively), as a consequence of the lower iron solubility after the in vitro digestion, but not as a result of decreased transport of the remaining soluble iron. The BD consumption increased iron fecal excretion ( approximately 1.4-fold) and significantly decreased its bioavailability ( approximately 2.7-fold), mainly due to the effects found at digestive level. Serum biochemical parameters related to iron metabolism remained unaltered. It is concluded the presence of MRP in the diet negatively affects iron bioavailability. As iron deficiency may be related to learning impairment and to reductions of cognitive and physical functions, possible long-term effects of excessive MRP intake during adolescence warrant attention.

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Section: Subjects Diets and Study Designmentioning

confidence: 99%

Intake of Maillard reaction products reduces iron bioavailability in male adolescents

Garcı́a¹,

Seiquer

Delgado-Andrade

et al. 2009

Molecular Nutrition Food Res

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“…It is probable that the iron concentrations of maternal milk are under homeostatic control due to the finding that both anemic women (Celada et al, 1982) and women taking iron supplements (Zavaleta et al, 1995) have breast milk levels of iron comparable with those of nonanemic women. Iron balance studies performed in full term male infants from their 3rd -17th week of life indicated that the group receiving an ironfortified diet formula (iron content 10.35 mg/L) retained upto 40 times more iron than the breast-fed infants (Schulz-Lell et al, 1987). Iron balance studies performed in full term male infants from their 3rd -17th week of life indicated that the group receiving an ironfortified diet formula (iron content 10.35 mg/L) retained upto 40 times more iron than the breast-fed infants (Schulz-Lell et al, 1987).…”

Section: Neurobehavioural Deficits Induced By Postnatal Iron Overloadmentioning

confidence: 99%

Neurobehavioural deficits following postnatal iron overload: I spontaneous motor activity

2003

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Five experiments that induced postnatal iron overload in mice are described. In Experiment I, exposure of NMRI mice to different doses (iron succinate: 0.0, 3.7 or 37.0 mg Fe 2+ /kg b. w., p.o.) on postnatal days (PD) 10 -PD12 indicated marked disruptions of spontaneous motor behaviour and habituation in the 37.0 mg Fe 2+ /kg dose group, and to a lesser extent the 3.7 mg Fe 2+ /kg dose group. Analysis of brain iron content indicated significantly more total iron (μg/g) in the basal ganglia, but not frontal cortex of the higher, 37 mg/kg, dose group. In Experiment II, newborn NMRI mice were administered Fe 2+ (7.5 mg/kg, b.w.) at either PD 3-5, PD 10-12 or PD 19-21, or vehicle (saline). Marked deficits in spontaneous motor behaviour and habituation were obtained in the mice administered iron during PD 10-12, and to a much lesser extent at PD 3-5. Analysis of total brain iron content indicated significantly more iron (mg/g) in the basal ganglia, but not frontal cortex of mice from PD 3-5 and PD 10-12 Fe 2+ treatment groups. In Experiment III, the interactive effects of postnatal iron overload and administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to adult C57 BL/6 mice were examined by postnatal administration of iron (Fe 2+ ) 7.5 mg/kg, b. wt., p.o. or vehicle (saline) at PD 10-12 followed, at 3-months of age, by administration of either MPTP (2 x 20 or 2 x 40 mg/kg, s.c.) or saline. Postnatal Fe 2+ (7.5 mg/kg) caused drastic disruptions of spontaneous motor activity and habituation at behavioural testing (4-months age), and adult MPTP treatment potentiated these disruptions. Neurochemical deficits in dopamine (DA) and its metabolites (dihydroxyphenylacetic acid, DOPAC; homovanillic acid, HVA) induced by MPTP treatment were exacerbated by prior postnatal administration of Fe 2+ . The analysis of total iron content (mg/g) in brain regions indicated notably elevated levels in the basal ganglia, but not in the frontal cortex of mice administered Fe 2+ at PD 10-12. MPTP-treated mice displayed severe depletions of DA, DOPAC and HVA in both the striatal and frontal cortical regions, i.e. Veh-MPTP40 as well as Fe-MPTP20 and Fe-MPTP40 groups, compared to the saline-treated (Vehicle) mice at 4-months of age, with lesser depletions by the Veh-MPTP20 group. In Experiment IV it was indicated that postnatal iron induced marked deficits (hypoactivity), initially, in all three parameters of motor activity at the 5.0 and 7.5 mg/kg doses, and to a lesser extent at the 2.5 mg/kg dose. Later combination with MPTP (2 x 40 mg/kg) potentiated severely these deficits. During the final period of testing a marked hyperactivity was obtained for the two higher dose groups; this effect was abolished in mice administered MPTP. In Experiment V, postnatal iron-induced deficits were alleviated in a dose-related manner by co-administration of the uncompetitive glutamate receptor antagonist, dizolcipine (MK-801), with a subthreshold dose of L-Dopa. Iron-overload during the immediate postnatal period seems detrimental for several...

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“…As the urinary excretion of Fe, Cu and Mn in formula-fed infants is negligible (Schulz-Lell et al, 1987;D6rner et al, 1989), urinary collection was not included in the studies. All samples were collected with plastic materials free of trace element contamination as determined by random tests.…”

Section: Collecting Proceduresmentioning

confidence: 99%

“…Studies on the influence of the longterm use of semisynthetic diets on the zinc, copper, calcium and selenium status in children with PKU revealed tile possible impairment of their trace element status (Hurry and Gibson, 1982;Lombeck et aI., 1984;Taylor et al, 1984;Longhi et al, 1987). The optimal trace element concentration of formulae for healthy infants is still controversial because of the limited number of studies (Schulz-Lell et at., 1987;D6rner et al, 1989). However, as human milk is regarded as the best nutrient for the healthy infant, it should be ensured that all infants absorb and retain trace elements in amounts equivalent to those obtained from human milk.…”

mentioning

confidence: 99%

“…We concentrated on the evaluation of balance data for the elements Fe, Cu and Mn and compared these data with those obtained from healthy term breastfed infants during preceding investigations (Schulz-Lell et al, 1987;D6rner et al, 1989). We concentrated on the evaluation of balance data for the elements Fe, Cu and Mn and compared these data with those obtained from healthy term breastfed infants during preceding investigations (Schulz-Lell et al, 1987;D6rner et al, 1989).…”

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Trace element excess in PKU diets?

Sievers

Oldigs

Dörner

et al. 1989

J of Inher Metab Disea

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Knowledge of trace element requirements of infants with phenylketonuria (PKU) fed a semisynthetic diet is limited. Three infants with PKU detected early were studied longitudinally in classical balance studies for 72 h, under domestic conditions, at the ages of 2, 5, 8, 12 and 16 weeks. Iron, copper and manganese concentrations in the diet and faeces were determined by atomic absorption spectroscopy. The median concentrations in the diet (4.8 mg Fe/L, 1.7 mg Cu/L, 0.43 mg Mn/L) exceed those in human milk. This is mainly due to supplementation of the amino acid preparation used. The increased intake led to a significantly higher daily retention of Cu and Mn from the PKU-diet fed, with a median of 0.17 mg Cu/kg and 6.4 micrograms Mn/kg body weight; the median retention of Fe was 0.24 mg Fe/kg. Our results confirmed the doubts about the suitability of the present trace element supplementation in formula for infants with PKU during the first four months of life.

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Iron Balances in Infant Nutrition

Cited by 31 publications

References 22 publications

Intake of Maillard reaction products reduces iron bioavailability in male adolescents

Intake of Maillard reaction products reduces iron bioavailability in male adolescents

Neurobehavioural deficits following postnatal iron overload: I spontaneous motor activity

Trace element excess in PKU diets?

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