Iron and vitamin D status in breastfed infants and their mothers

Kang, Yu Sun; Kim, Joon Hwan; Ahn, Eun Hee; Yoo, Eun-Gyong; Kim, Moon Kyu

doi:10.3345/kjp.2015.58.8.283

Cited by 13 publications

(18 citation statements)

References 36 publications

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“…Of these 10 articles, 90% of them were published in recent years,[11121314151617181920] between 2013 and 2015. All cross-sectional studies were conducted in Korea.…”

Section: Resultsmentioning

confidence: 99%

“…All cross-sectional studies were conducted in Korea. [111213] Over half of the trials were conducted in Spain;[14171820] one in the United States;[19] one in Japan;[16] and one in Israel. [15] We divided studies into two groups to specify the results (1) observational studies [Table 1] and (2) interventional studies that evaluated the effect of iron supplementation on Vitamin D status [Table 2].…”

Section: Resultsmentioning

confidence: 99%

“…Table 1 shows the characteristics of cross-sectional studies evaluating the relationship between iron and Vitamin D. All three included articles[111213] revealed that 25(OH)D was lower in anemic cases. Kang et al .…”

Section: Resultsmentioning

confidence: 99%

“…Kang et al . [12] showed that 25(OH)D level was significantly lower in infants of mothers with medical history of anemia during pregnancy ( P = 0.011). Although VDD had an odds ratio (OR) of 4.74 for the presence of iron deficiency, it was nonsignificant.…”

Section: Resultsmentioning

confidence: 99%

“…[10] Some recent studies blame IDA for VDD because of their linked metabolism. [111213] The results of studies in this area are inconsistent due to heterogeneity in study objectives and lack of determining the etiology of anemia. There are also several trials evaluating the effect of iron intake on Vitamin D concentration as their primary or secondary outcomes,[14151617181920] but there is no exclusive review on the effect of iron deficiency or its replenishment on Vitamin D status.…”

Section: Introductionmentioning

confidence: 99%

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Effects of iron on Vitamin D metabolism: A systematic review

et al. 2016

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Vitamin D is a prohormone nutrient, which is involved in skeletal and extra-skeletal functions. Iron is another essential nutrient that is necessary for the production of red blood cells and oxygen transport. This element plays important roles in enzymatic systems including those required for Vitamin D activation. To the best of our knowledge, there is no exclusive review on the relationship between iron deficiency anemia (IDA), as the most prevalent type of anemia, and Vitamin D deficiency and the effect of recovery from iron deficiency on Vitamin D status. The aim of this study was to conduct a systematic search of observational and clinical trials in this field. The databases of PubMed, ProQuest, Cochrane Library, ISI Web of Knowledge, and SCOPUS were searched comprehensively. English-language human studies conducted on iron deficient patients or interventions on the effect of iron therapy on Vitamin D were extracted (n = 10). Our initial search yielded 938 articles. A total of 23 papers met the inclusion criteria. Thirteen studies were excluded because they were not relevant or not defining anemia types. The final analysis was performed on ten articles (3 cross-sectional and 7 interventional studies). Observational data indicated a positive relationship between iron status and Vitamin D, while trials did not support the effectiveness of iron supplementation on improving Vitamin D status. The mechanism underlying this association may involve the reduction of the activation of hydroxylases that yield calcitriol. Future randomized controlled trials with large sample sizes and proper designs are needed to highlight underlying mechanisms.

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“…Of these 10 articles, 90% of them were published in recent years,[11121314151617181920] between 2013 and 2015. All cross-sectional studies were conducted in Korea.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of iron on Vitamin D metabolism: A systematic review

et al. 2016

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Maternal Iron and Vitamin D Status during the Second Trimester Is Associated with Third Trimester Depression Symptoms among Pregnant Participants in the APrON Cohort

Evanchuk,

Kozyrskyj,

Vaghef-Mehrabani

et al. 2024

The Journal of Nutrition

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Vitamin D deficiency and its association with iron deficiency in African children

Mogire

Muriuki

Morovat

et al. 2021

Preprint

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Background Nutritional deficiencies, including vitamin D and iron deficiency, are prevalent among children living in sub-Saharan Africa. Vitamin D inhibits the transcription of the iron hormone hepcidin thus permitting efficient iron absorption, and iron deficiency alters vitamin D metabolism. Studies have reported associations between vitamin D and iron status, but little is known about their association in African populations. Objective We aimed to evaluate the association between vitamin D and iron status in African children. Methods In this cross-sectional study, we measured biomarkers of iron status, inflammation and 25-hydroxyvitamin D (25(OH)D) levels in 4509 children aged 0.3 months to 8 years from Kenya, Uganda, Burkina Faso, The Gambia and South Africa. We used regression analyses to evaluate the association between vitamin D and iron status. Results Stunting, underweight, inflammation and malaria were highly prevalent. Overall prevalence of iron deficiency was 35.1%, while the prevalence of vitamin D deficiency was 0.6% and 7.8% as defined by 25(OH)D levels of <30 nmol/L and <50 nmol/L respectively. Children with 25(OH)D levels <50 nmol/L had an 80% increased risk of iron deficiency (OR 1.80 [95% CI 1.40, 2.31]) and had lower hepcidin levels than those with 25(OH)D levels >75 nmol/L. 25(OH)D levels were positively associated with ferritin, hepcidin and soluble transferrin receptor levels and negatively associated with serum iron and transferrin saturation in multivariable regression analyses. Vitamin D status was not associated with hemoglobin levels or anemia. Conclusions These findings suggest that vitamin D deficiency may variably influence different iron compartments and measures of iron status in young African children. Additional research is required to confirm these findings and determine direction of causality. The interplay between vitamin D and iron status should be considered in strategies to manage these nutrient deficiencies in African populations.

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Iron and vitamin D status in breastfed infants and their mothers

Cited by 13 publications

References 36 publications

Effects of iron on Vitamin D metabolism: A systematic review

Effects of iron on Vitamin D metabolism: A systematic review

Maternal Iron and Vitamin D Status during the Second Trimester Is Associated with Third Trimester Depression Symptoms among Pregnant Participants in the APrON Cohort

Vitamin D deficiency and its association with iron deficiency in African children

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