Iron Administration in the Critically III

Piagnerelli, Michaël; Rapotec, Alessandro; Cotton, Frédéric; Vincent, Jean Louis

doi:10.1053/j.seminhematol.2006.08.007

Cited by 5 publications

(1 citation statement)

References 30 publications

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“…The etiology of anemia in critically ill patients is multifactorial and includes blood losses (trauma, blood sampling, surgical procedures and occult gastrointestinal bleeding), decreased RBC production by functional iron deficiency, 4 and altered erythropoiesis (apoptosis of erythroid precursors and lower erythropoietin concentrations for a given hematocrit) 5,6 . Blood sampling is probably the main factor in the development of anemia in the critically ill, especially in patients with sepsis.…”

Section: Anemia In the Critically Illmentioning

confidence: 99%

Anemia in sepsis: the importance of red blood cell membrane changes

Piagnerelli¹,

Boudjeltia²,

Gulbis

et al. 2007

Transfus Alt Transfus Med

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SUMMARY Anemia is a common problem in acutely ill patients, especially in those who develop sepsis. There are many factors contributing to the development of anemia in these patients, including blood sampling and other losses, decreased red blood cell (RBC) synthesis, and possibly increased destruction. Increased RBC uptake may be due to changes in RBC morphology and the RBC membrane during inflammatory processes. In particular, a rapid increase in RBC sphericity correlated with a decreased surface carbohydrate membrane content and alterations in the lipid bilayer with increased peroxidation and phosphatidylserine exposure in the outer leaflet of the membrane. Better understanding of these alterations could facilitate new strategies to prevent the development of anemia in sepsis.

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Section: Anemia In the Critically Illmentioning

confidence: 99%