1999
DOI: 10.1016/s0301-5629(99)00046-0
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Iron accumulation in the substantia nigra in rats visualized by ultrasound

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Cited by 152 publications
(88 citation statements)
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“…TCS of post-mortem brains and animal studies indicate that this abnormality may be related to iron deposition with formation of free radicals [7,9].…”
Section: Discussionmentioning
confidence: 99%
“…TCS of post-mortem brains and animal studies indicate that this abnormality may be related to iron deposition with formation of free radicals [7,9].…”
Section: Discussionmentioning
confidence: 99%
“…The iron content in the SN was assessed using spectroscopy and the echogenicity of SN was measured as well. Increasing iron content increased the echogenicity of SN 14 . It is possible that a hyperechogenic and enlarged SN in atypical syndromes like MSA (multiple system atrophy) and VP (vascular parkinsonism) is caused by this mechanism.…”
Section: Echogenicity Of Substantia Nigra and Iron Metabolismmentioning
confidence: 94%
“…It has a sensitivity of about 90 % and specifi city of about 90 % (ref. [14][15][16][17][18] ) -see Table 1. The fi rst evaluations of the substantia nigra in PD patients were published in 1995.…”
Section: Tcs Evaluation Substantia Nigra In Parkinson's Diseasementioning
confidence: 99%
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