“…Another hallmark of active lesions is disruption of the blood-brain barrier (BBB), combined with leukocyte infiltration into the CNS (Kuhlmann et al, 2017;Grajchen et al, 2018). As a consequence, reactive microglia start synthesizing ROS, resulting in local oxidative stress, DNA damage, and neurotoxicity (Hametner et al, 2013(Hametner et al, , 2018Yauger et al, 2019). These iron-laden microglia have the tendency to stay in this proinflammatory state, impairing clearance of myelin debris, making it harder for oligodendrocytes to migrate toward the lesion site and, as a result, complicating remyelination processes (Mairuae et al, 2011;Lee et al, 2019).…”