Iron Absorption

Heme- and nonheme-iron absorption and iron status 12 mo after sleeve gastrectomy and Roux-en-Y gastric bypass in morbidly obese women

“…Iron homeostasis is largely dependent on iron absorption (34,35). Baseline heme-and nonheme-iron absorption were within the range reported in other studies (16,36).…”

“…A major feature of both SG and RYGBP is the dramatic reduction in stomach size; therefore, an immediate consequence is a reduction in foodgastric juice interaction. Gastric juice is crucial to the release of heme from dietary hemoglobin and myoglobin (35), and it has a role in the release of nonheme iron from its protein matrix and in the solubilization and ionization of dietary iron (42). Besides, intraluminal inhibiting and enhancing factors are more relevant to nonheme-iron absorption that to heme-iron absorption (34,35).…”

Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review

“…In 1963 Cook and colleagues observed a significant impairment of iron absorption in patients with PA, which was corrected by adding gastric juice[ 50 ]. On the other hand, later studies did not confirm those observations and reported that the achlorhydria-induced malabsorption of dietary iron was unlikely to be the primary etiology of iron deficiency[ 51 , 52 ]. In recent years, however, the co-existence of CAAG and iron deficiency anemia (IDA) has been increasingly reported.…”

Introduction: Knights of the oval table

“…The distinctive feature of absorption is the movement of iron through the absorptive cell, which can be called the ‘throughput’ [16]. This is not to say that other changes in the absorptive process may not also occur, such as an alteration in initial membrane uptake by the intestinal mucosa, but sequential measurements suggest that this is not the limiting step.…”