Irisin Protects Against Hind Limb Ischemia Reperfusion Injury

Küçük, Ayşegül; Polat, Yücel; Kılıçarslan, Aydan; Süngü, Nuran; Kartal, Hakan; Dursun, Ali Doğan; Arslan, Mustafa

doi:10.2147/dddt.s279318

Cited by 9 publications

(6 citation statements)

References 31 publications

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“…Total antioxidant status (TAS, mmol Trolox Eq/L), total oxidant status (TOS, mmol H 2 O 2 Eq/L), oxidative stress index (OSI-TOS/TAS), paraoxonase (PON, U/L), total thiol (µmol/L), serum native thiol (µmol/L), nitric oxide (NO, µmol/L), and disulfide levels were measured for subjects. 12,13…”

Section: Oxidative Stress Assays and Oxidative Stress Markersmentioning

confidence: 99%

Laboratory and Imaging Evaluation of Cardiac Involvement in Patients with Post-Acute COVID-19

Sarıçam¹,

Dursun²,

Sarıyıldız³

et al. 2021

IJGM

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Background In the post-acute COVID-19 syndrome, many patients suffer from palpitations, effort-associated fatigue, and even sudden death. The mechanism of heart involvement in this syndrome is uncertain. The main purpose of the study was to identify possible cardiac involvement causes in patients with post-acute COVID-19 by using biomarkers such as NT-proBNP and nitric oxide (NO) and cardiac imaging modalities. Methods In this cross-sectional study, a total of 105 participants were included according to the existence of symptoms, and 40 of these participants were asymptomatic patients. The ages of the participants ranged from 20 to 50 years. All patients were healthy before COVID-19. The symptoms were defined as palpitations and/or fatigue association with exercise in post-acute COVID-19 term. The comparison of the two groups was made by using biochemical parameters (NT-proBNP, Troponin I, NO) and imaging techniques (echocardiography, cardiovascular magnetic resonance (CMR) and cardiac positron emission tomography (PET)). Results The symptomatic patients had higher NT-proBNP levels compared with asymptomatic patients (132.30±35.15; 76.86±16.79, respectively; p < 0.001). Interestingly, the symptomatic patients had lower NO levels than asymptomatic patients (9.20±3.08; 16.15±6.02, respectively; p < 0.001). Echocardiography and CMR were normal. However, we found regional increased 18F-FDG uptake on cardiac PET to be compatible with myocardial fatigue. Conclusion We found elevated NT-proNBP levels, low serum NO levels, and increased 18F-FDG uptake on cardiac PET in post-acute COVID syndrome. Cardiac PET could replace or be added to CMR for detecting subtle subacute/chronic myocarditis. The follow-up of patients with post-acute COVID-19 could target the possibility of risk of heart failure.

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Section: Oxidative Stress Assays and Oxidative Stress Markersmentioning

confidence: 99%

Laboratory and Imaging Evaluation of Cardiac Involvement in Patients with Post-Acute COVID-19

Sarıçam¹,

Dursun²,

Sarıyıldız³

et al. 2021

IJGM

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“…Regarding the association of low FNDC5 /irisin expression with risk of ICU-acquired weakness, it is interesting to note that lower preoperative plasma irisin levels in elderly patients correlated with preoperative bedrest time as a surrogate marker of muscle wasting, and were associated with lower independence for performing activities of daily living [ 31 ], whereas irisin treatment of mice exerted muscle-protective effects. Indeed, this treatment induced significant hypertrophy and enhanced grip strength of uninjured muscle, improved regeneration and rescued loss of muscle mass of denervation-induced injured muscle, and showed beneficial effects in hind limb ischemia–reperfusion injury [ 44 , 45 ]. We also observed an association of lower FNDC5 expression in muscle with signs of inflammation in muscle and with a higher proportion of smaller myofibers.…”

Section: Discussionmentioning

confidence: 99%

Skeletal Muscle Myokine Expression in Critical Illness, Association With Outcome and Impact of Therapeutic Interventions

Vanhorebeek

Gunst

Casaer

et al. 2023

Journal of the Endocrine Society

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Context Muscle expresses and secretes several myokines that bring about benefits in distant organs. Objective We investigated impact of critical illness on muscular expression of irisin, kynurenine-aminotransferases and amylase; association with clinical outcome; and impact of interventions that attenuate muscle wasting/weakness. Design/Setting We studied critically ill patients who participated in two RCTs (EPaNIC/NESCI) and documented time profiles in critically ill mice. Patients/other participants 174 intensive-care-unit (ICU) patients (day 8 ± 1) vs 19 matched controls, 60 mice subjected to surgery/sepsis vs 60 pair-fed healthy mice. Interventions Seven-days neuromuscular electrical stimulation (NMES), withholding parenteral-nutrition in the first ICU-week (late-PN) vs early-PN. Main outcome measures FNDC5 (irisin-precursor), KYAT1, KYAT3 and amylase mRNA-expression in skeletal-muscle. Results Critically ill patients showed a 34-80% lower mRNA-expression of FNDC5, KYAT1 and amylases compared with controls (p < 0.0001). Critically ill mice showed time-dependent reductions in all mRNAs compared with healthy mice (p ≤ 0.04). The lower FNDC5 expression in patients was independently associated with a higher ICU-mortality (p = 0.015) and ICU-acquired weakness (p = 0.012), whereas the lower amylase expression in ICU survivors was independently associated with a longer ICU-stay (p = 0.0060). A lower amylase expression was independently associated with a lower risk of death (p = 0.048) and a lower KYAT1 expression with a lower risk of weakness (p = 0.022). NMES increased FNDC5 expression compared with unstimulated muscle (p = 0.016), and late-PN patients had a higher KYAT1 expression than early-PN patients (p = 0.022). Conclusions Expression of the studied myokines was affected by critical illness and associated with clinical outcomes, with limited effects of interventions that attenuate muscle wasting or weakness.

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Section: Methodsmentioning

confidence: 99%

“…Total antioxidant status (TAS, mmol Trolox Eq/L), total oxidant status (TOS, mmol H2O2 Eq/L), oxidative stress index (OSI-TOS/TAS), oxonase (PON, U/L), nitric oxide (NO, μmol/L) levels were measured for the patients. 12,13 The analyses of serum biochemical oxidative stress marker parameters were performed on an auto analyzer (Mindray BS 300) using commercial kits (RelAssay Diagnostic, Turkey). Venous blood samples were collected from all of the patients.…”

Section: Oxidative Stress Assays and Oxidative Stress Markersmentioning

confidence: 99%

The Evaluation of Oxidative Stress in the Young Adults with COVID-19 mRNA Vaccines Induced Acute Pericarditis- Myopericarditis

Dursun¹,

Sarıçam²,

Sarıyıldız³

et al. 2022

IJGM

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Background: During COVID-19 pandemic, several vaccines have been developed such as mRNA vaccines. However, acute pericarditis and myocarditis/myopericarditis cases have been described after mRNA vaccination. The mechanism for the development of cardiac involvement is unknown. Potential mechanism for oxidative stress associated with vaccine-induced heart involvement is unidentified. This study aimed to examine the role of oxidative stress and the heart involvement in young adults vaccinated with COVID-19 mRNA vaccines. Methods: In this cross-sectional study, a total of 23 participants were included and 10 of these participants were asymptomatic patients (control group). Comparison of the cardiac involvement and control group was made by using troponin I, C-reactive protein (hsCRP), D-dimer levels, and oxidative stress tests including nitric oxide, and imaging techniques (ECG, echocardiography, cardiovascular magnetic resonance). Results:The median age of acute pericarditis group (10 patients) was 22 years (Q1-Q3: 18.5-31), and the mean age was 24.4±7.5 years. The median age of myopericarditis group (3 patients) was 22 years (Q1-Q3 18.0-25.0), and the mean age was 21.6 ±3.5 years. All the myopericarditis cases were male. The patients with myopericarditis had higher troponin I level, hsCRP, and D-dimer levels (troponin I level; 1600.00 ng/mL; D-dimer; 1.20 μg/mL, hsCRP; 3.0 mg/L, respectively; p < 0.05). Serum nitric oxide levels and OSI (total oxidant status, H 2 O 2 /total antioxidant status) were lower in myopericarditis group than the control and acute pericarditis group (p < 0.05). This shows inflammatory and procoagulant state. Conclusion: Vaccine-induced myopericarditis cases are associated with oxidative stress test abnormality (abnormal NO, OSI levels). However, there is no relationship between NO levels and other oxidative stress tests difference in vaccine-induced acute pericarditis. It is thought that vaccine-induced pericarditis and myopericarditis could have different pathogenesis. This could make it necessary to reassess the second dose of vaccination for vaccineinduced cardiac involvement cases.

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Irisin Protects Against Hind Limb Ischemia Reperfusion Injury

Cited by 9 publications

References 31 publications

Laboratory and Imaging Evaluation of Cardiac Involvement in Patients with Post-Acute COVID-19

Laboratory and Imaging Evaluation of Cardiac Involvement in Patients with Post-Acute COVID-19

Skeletal Muscle Myokine Expression in Critical Illness, Association With Outcome and Impact of Therapeutic Interventions

The Evaluation of Oxidative Stress in the Young Adults with COVID-19 mRNA Vaccines Induced Acute Pericarditis- Myopericarditis

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