Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery

Abstract

Irisin, an adipomyokine identified in 2012, has been investigated in association with common pregnancy complications, including gestational diabetes mellitus, preeclampsia, and intrauterine growth restriction. The objective of this study is to examine the potential role of irisin in preterm birth (PTB) by comparing its level between mothers with term and preterm labor. Maternal peripheral blood and cord blood samples were collected from 30 mothers who delivered prematurely and from 35 mothers who delivered at term. Irisin concentrations were measured in all samples using ELISA, and four common single nucleotide polymorphisms in the irisin gene were determined (rs16835198, rs726344, rs3480, and rs1746661). Univariable and multivariable regression modeling was applied to evaluate maternal and cord blood irisin concentrations in relation to preterm/term labor. Irisin concentration in umbilical cord blood was found to be associated with PTB in the univariable model (p = 0.046). On the other hand, no differences in maternal blood irisin levels between mothers with preterm and term deliveries were established. To the best of our knowledge, this is the first study determining irisin levels in term and preterm deliveries in maternal peripheral blood and umbilical cord blood. Our study shows a possible association between cord blood irisin concentration and PTB occurrence.

Serum Levels of Irisin and Omentin-1 in Breast Neoplasms and Their Association with Tumor Histology

“…In that study, irisin concentrations were reported in the range of 3-5 ng/ml [42] which is lower than the values reported herein. However, our findings are of a similar magnitude with other published studies using the same ELISA kit [43][44][45][46] and indeed slightly higher than the Tandem Mass Spectrometry but significantly lower compared to assays used in different studies. In fact, our assay's linear range is 1.29-27.5 ng/ml, and the assay can detect irisin levels between 10 and 50 ng/ml.…”

The Role of the Adipokines in the Most Common Gestational Complications

“…A higher irisin level in preterm infants compared with term deliveries was discovered. It could be described by the fact that the onset of labor provides a strong stimulus for the release of irisin into maternal and fetal circulations [ 145 , 151 ], and could increase cord blood irisin level by nearly 40% [ 152 ]. In addition, it has been suggested that increased irisin release into cord blood may be caused by temporary uteroplacental ischemia during vaginal delivery, thus leading to fetal stress [ 145 ].…”

Relationship of Circulating Irisin with Body Composition, Physical Activity, and Cardiovascular and Metabolic Disorders in the Pediatric Population

“…Measurement of irisin in umbilical cord blood has shown that irisin levels are lower in small for gestational age (SGA) newborns compared with appropriate for gestational age (AGA) and large for gestational age (LGA) neonates [36,37,38]. In contrast, in a study of Caucasian women, a higher irisin level in preterm infants compared with term infants was found [39]. Irisin levels were also significantly higher in maternal blood compared with umbilical cord blood.…”