Irisin level in type 2 diabetic patients and its relation to glycemic control and diabetic complications

Haddad, Hemmat El; Sedrak, Heba; Naguib, Mervat; Yousief, Elham M.; Ibrahim, Dalia Ramzy; Samie, Rasha M. Abdel; Hamdy, Ahmed

doi:10.1007/s13410-019-00717-2

Cited by 8 publications

(5 citation statements)

References 32 publications

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“…The relationship between irisin levels and markers of insulin resistance/glycemic control is controversial, however. Irisin levels were reported to be negatively [22] or positively associated with HbA1c levels in T2DM patients [23]. No significant correlations between irisin levels and HbA1c or fasting glucose levels were found in the present study.…”

Section: Discussioncontrasting

confidence: 74%

Effects of a Combined Endurance/Strength Training Program on Circulating Irisin Levels in Overweight/Obese Men and Women with Type 2 Diabetes Mellitus

Brinkmann

Weh-Gray

Bloch

et al. 2020

Exp Clin Endocrinol Diabetes

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Irisin is a promising therapeutic target in patients with type 2 diabetes mellitus (T2DM), as studies have demonstrated that irisin can induce “browning“ of adipocytes and mitigate pro-inflammatory conditions. Sex-specific changes in irisin levels have been reported in a study involving healthy men and women following physical training. The present study aims to analyze the effects of an 8-week training intervention on circulating irisin levels in patients with T2DM and to find out whether the training responses differ between T2DM men and women. Twenty-nine overweight/obese T2DM patients (19 men, 10 women; age: 46–74 years; body mass index >25 kg/m2) participated in a combined moderate-intensity endurance/strength training program (3 times a week). The irisin levels of men and women did not differ significantly. The post-training irisin levels did not differ significantly from the pre-training values, and there was no interaction effect of sex. This study shows no training-induced (sex-specific) changes in circulating irisin levels in T2DM patients. Large-scale studies using other forms of training are needed to fully clarify whether basal irisin levels can be changed in T2DM men and/or women to counteract T2DM.

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Section: Discussioncontrasting

confidence: 74%

Effects of a Combined Endurance/Strength Training Program on Circulating Irisin Levels in Overweight/Obese Men and Women with Type 2 Diabetes Mellitus

Brinkmann

Weh-Gray

Bloch

et al. 2020

Exp Clin Endocrinol Diabetes

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“…Although the association between plasma irisin in pregnancy and postpartum FBG has not been reported previously, several studies have observed negative associations between irisin and FBG in other populations [11][12][14][15]29 . For instance, Zhao et al 14 reported that irisin levels were negatively correlated with FBG in pregnant women, of whom 50% were patients with GDM.…”

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 95%

“…Other experimental studies also showed that irisin might improve glucose homeostasis by reducing insulin resistance and promoting b-cell survival [8][9][10] . Subsequently, population-based studies have shown lower irisin levels in individuals with type 2 diabetes mellitus [11][12][13] , and some concluded a negative association between irisin and fasting blood glucose (FBG) 11,[14][15] . However, other literature reported a null 16 or even positive [17][18] correlation.…”

Section: Introductionmentioning

confidence: 99%

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Association between plasma irisin in pregnancy and postpartum glucose levels among Chinese women: A cohort study

Tang

Chen

et al. 2021

J of Diabetes Invest

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Aims/Introduction: The association between plasma irisin and glucose levels in the general population is controversial, and few studies have longitudinally detected this correlation. We aimed to examine whether irisin in pregnancy was associated with postpartum glucose levels among Chinese women and explore the modifiable factors. Materials and Methods: We carried out a prospective cohort study in Guangzhou, China, during 2017 and 453 pregnant women (20-28 weeks) were enrolled. Plasma irisin levels in pregnancy were tested. At 6-8 weeks after delivery, 93 women with gestational diabetes mellitus (GDM) underwent a 75-g oral glucose tolerance test, and the other 360 women had a fasting blood glucose (FBG) test. Multivariable linear, quantile and logistic regressions were carried out. Results: The mean plasma irisin in mid-pregnancy was 13.73 ng/mL. We observed a significantly negative association between mid-pregnancy irisin and postpartum FBG (b: -0.056 -0.024). However, quantile regression showed the association was only significant in high percentiles of FBG levels (P 50 to P 95 ), and the magnitude showed an increasing trend. Higher baseline irisin was also associated with a lower risk of postpartum impaired fasting glucose (relative risk 0.563, 95% confidence interval 0.384-0.825). Furthermore, we found significant interactions between irisin and predominant breast-feeding on FBG and impaired fasting glucose (both P interaction < 0.05). In women with GDM, baseline irisin was non-significantly associated with postpartum postprandial 2-h glucose levels (b: -0.305 -0.160, P = 0.061). Conclusions: Plasma irisin levels in mid-pregnancy were negatively associated with FBG levels and impaired fasting glucose at 6-8 weeks postpartum among Chinese women, and stronger associations were observed in women with higher FBG values. Furthermore, breast-feeding might modify this relationship.

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“…However, a substantial correlation was detected between irisin level and FBS, HbA1C, CRP, cholesterol, and TG. 28 He et al, demonstrated a significant correlation between irisin with HbA1C and LDL-C in 71 patients with T2DM and 40 normal control patients. Like our study, the irisin level was significantly lower in people with diabetes than in controls (p<0.001), and no significant correlation was observed between irisin and lipid parameters of TG and HDL-C. 29 The low concentration of irisin in patients with T2DM could be attributed to the low level of PGC-1α expression.…”

Section: Discussionmentioning

confidence: 98%

The Potential Relationship Between Serum Irisin Concentration with Inflammatory Cytokines, Oxidative Stress Biomarkers, Glycemic Indices and Lipid Profiles in Obese Patients with Type 2 Diabetes Mellitus: A Pilot Study

Khajebishak¹,

Faghfouri²,

Soleimani³

et al. 2023

JAFES

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Objectives. Diabetes mellitus is a serious health-treated problem identified by disorders such as insulin resistance, dyslipidemia, and inflammation. Irisin, a newly discovered myokine/adipokine, is involved in metabolic homeostasis. The present study was carried out to investigate the potential relationship between serum irisin with inflammatory cytokines, oxidative stress biomarkers, glycemic indices, and lipid profiles in obese patients with type 2 diabetes mellitus.Methodology. This analytical cross-sectional study was conducted on 62 participants (n=32 obese participants with diabetes, n=30 participants with normal weight). The participants answered a demographic questionnaire. Serum irisin, glycemic indices, lipid profiles, inflammatory cytokines and oxidative stress biomarkers were measured using standard methods. The difference between groups was assessed by independent-sample t-test or by a non-parametric equivalent. For qualitative variables, the Chi-Square test was used. Pearson rho coefficient was used to determine the potential relationship between irisin and inflammatory cytokines, oxidative stress biomarkers, glycemic indices, and lipid profiles. A p<0.05 was defined as significant.Results. The median (IQR) age of the obese participants with diabetes was 54.0 years (52.2-60.7) and in the normal weight group was 38.0 years (30.0-47.2) (p<0.001). About 78% and 60% of participants in the obese with diabetes and the normal weight groups were females (p>0.05), respectively. Significant differences were observed in serum irisin levels between the two groups, with lower levels (218.74 ng/mL, [144.98-269.26]) noted in the obese with diabetes group compared to the normal weight group (266.68 ng/mL, [200.64-336.57]) with a p=0.024. There was a substantial difference between the two groups regarding IL-6, TNF-α, and hs-CRP (p<0.05). IL-6 had a moderate negative correlation with irisin in obese patients with T2DM (r=-0.478, p=0.006). Conclusion.Irisin concentration was detected to be lower in obese people with diabetes. A negative relationship was detected between irisin and IL-6. Considering emerging evidence about the beneficial functions of irisin in improving metabolic abnormalities, designing future studies with greater sample sizes that will validate these results is needed.

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Irisin level in type 2 diabetic patients and its relation to glycemic control and diabetic complications

Cited by 8 publications

References 32 publications

Effects of a Combined Endurance/Strength Training Program on Circulating Irisin Levels in Overweight/Obese Men and Women with Type 2 Diabetes Mellitus

Effects of a Combined Endurance/Strength Training Program on Circulating Irisin Levels in Overweight/Obese Men and Women with Type 2 Diabetes Mellitus

Association between plasma irisin in pregnancy and postpartum glucose levels among Chinese women: A cohort study

The Potential Relationship Between Serum Irisin Concentration with Inflammatory Cytokines, Oxidative Stress Biomarkers, Glycemic Indices and Lipid Profiles in Obese Patients with Type 2 Diabetes Mellitus: A Pilot Study

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