Irisin injection mimics exercise effects on the brain proteome

Dehghan, Fariba; Zamani, Saman; Barreiro, Carlos; Jami, Mohammad‐Saeid

doi:10.1111/ejn.15493

Cited by 15 publications

(10 citation statements)

References 125 publications

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“…A novelty of this study was that irisin was directly administered to the studied PD model rather than induced by exercise. A previous study in mice implementing cellular pathway analysis showed that irisin injection has similar effects with exercise on brain proteome [ 51 ] supporting the idea that irisin administration could be used instead of exercise when the latter is not feasible.…”

mentioning

confidence: 69%

Could exercise hormone irisin be a therapeutic agent against Parkinson’s and other neurodegenerative diseases?

Avgerinos

2023

Metabolism Open

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mentioning

confidence: 69%

Could exercise hormone irisin be a therapeutic agent against Parkinson’s and other neurodegenerative diseases?

Avgerinos

2023

Metabolism Open

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“…Physical activity has beneficial effects on brain health and cognitive functions. Furthermore, it is known that physical activity has protective effects against neurodegenerative diseases and improves the symptoms (37). Physical exercise is recommended as an alternative treatment to reduce epileptiform discharges and seizure frequency, to increase cardiorespiratory fitness and muscle strength, and to provide better health conditions (38).…”

Section: Discussionmentioning

confidence: 99%

Effect of irisin on the epilepsy induced by penicillin G: An electrophysiological study

YILDIZ¹,

DEMİR²,

Beyazçiçek³

et al. 2022

J Exp Clin Med

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Epilepsy is a neurological disease characterized by sudden and synchronized seizures caused by abnormal and excessive electrical discharges in brain neurons. The purpose of this study was to electrophysiologically examine the effects of acute administration of irisin, which is thought to be neuroprotective and increase cell proliferation, at different doses (10 and 100 nM) on the penicillin-induced experimental epilepsy in rats. Fortynine adult male Wistar rats were used in the study. The rats were divided into 7 groups: sham, control group (penicillin), irisin group, the pre-and during-seizure groups of 10 nM and 100 nM irisin. All the substances except penicillin were administered intraperitoneally. The rats were anesthetized using urethane. The bone tissue on the left cerebral cortex was removed and the electrodes were placed in the somatomotor cortex. Thirty minutes before penicillin administration, irisin was administered to the pre-seizure penicillin group at doses of 10 nM and 100 nM. Then, penicillin (500 IU/2 µl) was injected intracortically, and ECoG recording was continued for 120 minutes. On the other hand, 10 nM and 100 nM of irisin were administered to the during-seizure penicillin group after penicillin was injected intracortically and the seizure occurred, and ECoG recording was continued for 120 minutes. The ECoG recordings were analyzed using the PowerLab Chart v.8 software. In conclusion, it was found that irisin prolonged the latency of initial epileptic activity and decreased the number and amplitude of spike-waves in the penicillin-induced experimental epilepsy model. These results suggest that irisin might have an antiepileptic potential.

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“…To examine the role of irisin in PD, irisin was peripherally delivered before or after the establishment of MPTP treated mice to explore its effect on neuroprotection and treatment (Fig. 1a, m), in which irisin injection dose was the median dose reported in literature 13,17,20,22,23,[25][26][27][28][29] . To evaluate the effect of irisin in MPTPinduced motor disfunction, we evaluated behavioral tests in mice.…”

Section: Peripherally Delivered Irisin Improves Motor Function and Do...mentioning

confidence: 99%

“…Irisin contains 112 amino acids, is heavily glycosylated and is 100% conserved between mouse and human 11 , 12 . Currently, irisin could be regarded as an extremely promising myokine since the effect of peripheral irisin injection in mice was very similar to that led by endurance exercise 13 , and exercise has been proposed as a non-pharmacological management for people who are in the early stages of PD or people who are experiencing balance or motor function problems 14 , 15 . The structure of irisin and its elevation with endurance exercise in humans has been confirmed using tandem mass spectrometry of human plasma 16 .…”

Section: Introductionmentioning

confidence: 99%

Irisin exhibits neuroprotection by preventing mitochondrial damage in Parkinson’s disease

Zhang

et al. 2023

npj Parkinsons Dis.

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Exercise has been proposed as an effective non-pharmacological management for Parkinson’s disease (PD) patients. Irisin, a recently identified myokine, is increased by exercise and plays pivotal roles in energy metabolism. However, it remains unknown whether irisin has any protective effects on PD. Here, we found that serum irisin levels of PD patients were markedly elevated after 12-week regular exercise, which had a positive correlation with improved balance function scored by Berg Balance Scale. Treatment with exogenous irisin could improve motor function, and reduce dopaminergic neurodegeneration in PD models. Meanwhile, irisin could reduce cell apoptosis by renovating mitochondrial function in PD models, which was reflected in decreased oxidative stress, increased mitochondrial complex I activity and mitochondrial content, increased mitochondrial biogenesis, and repaired mitochondrial morphology. Furthermore, irisin regulated the aforementioned aspects by upregulating downstream Akt signaling pathway and ERK1/2 signaling pathway through integrin receptors rather than directly targeting mitochondria. With the use of small-molecule inhibitors, it was found that irisin can reduce apoptosis, restore normal mitochondrial biogenesis, and improve mitochondrial morphology and dynamic balance in PD models by activating Akt signaling pathway and ERK1/2 signaling pathway. And irisin reduced oxidative stress via activating ERK1/2 signaling pathway. The results revealed that exogenous irisin conferred neuroprotection relieving apoptosis and oxidative stress, restraining mitochondrial fragmentation, and promoting mitochondrial respiration and biogenesis in PD models, and irisin exerted the aforementioned effects by activating Akt signaling pathway and ERK1/2 signaling pathway. Thus, peripherally delivered irisin might be a promising candidate for therapeutic targeting of PD.

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Irisin injection mimics exercise effects on the brain proteome

Cited by 15 publications

References 125 publications

Could exercise hormone irisin be a therapeutic agent against Parkinson’s and other neurodegenerative diseases?

Could exercise hormone irisin be a therapeutic agent against Parkinson’s and other neurodegenerative diseases?

Effect of irisin on the epilepsy induced by penicillin G: An electrophysiological study

Irisin exhibits neuroprotection by preventing mitochondrial damage in Parkinson’s disease

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