Irisin in Response to Exercise in Humans With and Without Metabolic Syndrome

Huh, Joo Young; Siopi, Aikaterina; Mougios, Vassilis; Park, Kyung-Hee; Mantzoros, Christos S.

doi:10.1210/jc.2014-2416

Cited by 163 publications

(139 citation statements)

References 23 publications

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“…Hofmann et al (60) recently reported in a review that of 10 human studies assessing the role of exercise in inducing muscle FNDC5 mRNA expression or increasing circulating irisin, only half reported a positive effect of exercise on FNDC5/irisin induction. Of an additional three studies, only one reported an increase in serum irisin following exercise (27,61,62). However, the 13 studies used different lengths (acute versus chronic) and intensities of exercise, and the human populations studied differed.…”

Section: Discussionmentioning

confidence: 99%

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SMAD3 Negatively Regulates Serum Irisin and Skeletal Muscle FNDC5 and Peroxisome Proliferator-activated Receptor γ Coactivator 1-α (PGC-1α) during Exercise

Tiano

Springer

Rane

2015

Journal of Biological Chemistry

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Background: Mothers against decapentaplegic homolog 3 (SMAD3) and FNDC5/irisin are molecules that modulate energy metabolism and body weight regulation. Results: SMAD3 negatively regulates irisin during exercise and suppresses FNDC5 and PGC-1␣ in cultured skeletal muscle cells. Conclusion: SMAD3 suppresses irisin/FNDC5 in skeletal muscle. Significance: This study sheds light on the poorly understood regulation of irisin/FNDC5 in skeletal muscle.

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Section: Discussionmentioning

confidence: 99%

“…1 ing (or following) exercise (16). Subsequent to its discovery, circulating irisin was found in adult humans and shown to be induced by exercise (23)(24)(25)(26)(27) and by cold exposure (28). Recently, a series of studies have demonstrated that the TGF-␤ pathway plays an important role in energy expenditure and body weight regulation (29 -32).…”

mentioning

confidence: 99%

SMAD3 Negatively Regulates Serum Irisin and Skeletal Muscle FNDC5 and Peroxisome Proliferator-activated Receptor γ Coactivator 1-α (PGC-1α) during Exercise

Tiano

Springer

Rane

2015

Journal of Biological Chemistry

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“…More recently they also demonstrated that irisin levels increased after acute exercise in patients with metabolic syndrome similar to healthy individuals, giving us a clue about irisin's unchanged instant compensatory behaviour in metabolic impairment. However, they suggested that a state of insulin resistance may exist in target organs in patients with metabolic syndrome, thus, showing us a need of a larger scale study to elucidate this issue [36]. There are ongoing controversies and topics to be elucidated about exercise and irisin relationship.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Irisin levels in the progression of diabetes in sedentary women

Duran

Gülçelik

Ünal

et al. 2015

Clinical Biochemistry

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“…Myokines are induced by exercise in rodents and humans, are related to browning in adipose tissue and are found to increase energy expenditure in mice without influencing movement and food intake, leading to a decrease in obesity and an improvement in glucose homeostasis [6]. Recent studies have reported that irisin is linked to T2DM [7] and MetS [8] in adults. However, there are only a few studies that have evaluated the relationship between irisin and MetS in pediatrics.…”

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confidence: 99%

Irisin is a biomarker for metabolic syndrome in prepubertal children

et al. 2018

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Abstract. The aim of the present study was to evaluate the association of irisin with obesity and metabolic syndrome (MetS) in Korean prepubertal children. A total of 96 children and adolescents aged 6 to 10 years (56 males) were included in this study. Subjects were divided into 3 groups: normal weight (n = 54), overweight (n = 16), and obese (n = 26). In the subgroup analyses, overweight/obese children were further divided based on their MetS status (with MetS vs. without MetS). Children with obesity tended to exhibit a lower mean irisin concentration compared to those with normal weight (p = 0.028). Using Pearson's correlation coefficient to compare all the children in the study, there was a significant inverse correlation between irisin and body mass index (BMI) standard deviation scores (SDS) (r = -0.210, p = 0.041), waist circumference SDS (r = -0.203, p = 0.049), and glucose (r = -0.296, p = 0.004). In the subgroup analyses of overweight/obese children, irisin exhibited a significant inverse correlation with glucose (r = -0.507, p = 0.001) and triglycerides (r = -0.331, p = 0.033). Children with MetS exhibited lower irisin concentrations than those without MetS (14.70 ng/mL vs. 22.02 ng/mL, p = 0.001), and these associations were significant after adjusting for age, gender, and BMI SDS (14.51 ng/mL vs. 22.06 ng/mL, p = 0.002). The irisin level of 15.43 ng/mL was determined to be a possible cutoff to distinguish children with metabolic syndrome from overweight/obese children, with a sensitivity of 75% and a specificity of 94% (p < 0.001). Our results suggest that decreased irisin levels may be associated with MetS in prepubertal children and that irisin might be a biomarker for MetS in prepubertal children. WITH an increasing population of overweight and obese children, metabolic complications associated with being overweight/obese, such as insulin resistance, hypertension and dyslipidemia, have become a major public health concern [1]. The incidence of childhood metabolic syndrome (MetS), which is closely related to insulin resistance, is defined as a clustering of abdominal obesity, hypertension, dyslipidemia and glucose intolerance and is increasing around the world, including in Korea [2]. The clustering of metabolic risk factors begins in childhood [3], and these multiple risk factors tend to persist from childhood into adulthood [4]. Childhood MetS is a risk factor for MetS, cardiovascular diseases and Submitted Jun. 15, 2017; Accepted Aug. 16, 2017 as EJ17-0260 Released online in J-STAGE as advance publication Sep. 12, 2017 Correspondence to: Il Tae Hwang, MD, PhD, Department of Pediatrics, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 150 Seongan-ro, Gangdong-gu, Seoul, Korea, 05338 E-mail: ithwang83@hallym.or.kr type 2 diabetes mellitus (T2DM) in adulthood [5]. It is therefore important to identify early MetS in children and adolescents.Recently, adipokines (i.e., adipocyte-secreted proteins) and myokines (i.e., myocyte-secreted proteins) have been s...

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Irisin in Response to Exercise in Humans With and Without Metabolic Syndrome

Abstract: Exercise is able to increase circulating irisin levels in individuals with the metabolic syndrome as well as healthy individuals. Whether this increase may contribute to the beneficial effects of exercise on patients with the metabolic syndrome remains to be studied further.

Cited by 163 publications

References 23 publications

SMAD3 Negatively Regulates Serum Irisin and Skeletal Muscle FNDC5 and Peroxisome Proliferator-activated Receptor γ Coactivator 1-α (PGC-1α) during Exercise

SMAD3 Negatively Regulates Serum Irisin and Skeletal Muscle FNDC5 and Peroxisome Proliferator-activated Receptor γ Coactivator 1-α (PGC-1α) during Exercise

Irisin levels in the progression of diabetes in sedentary women

Irisin is a biomarker for metabolic syndrome in prepubertal children

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