Irisin in idiopathic foetal growth restriction

Çağlar, Mete; Göksu, Mehmet; Isenlik, Bekir Sıtkı; Yavuzcan, Ali; Yılmaz, Musa; Üstün, Yusuf; Aydın, Süleyman; Kumru, Selahattin

doi:10.1007/s40618-014-0078-5

Cited by 20 publications

(11 citation statements)

References 31 publications

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“…In accordance with previous reports, we found that irisin concentrations were lower in newborns compared with their mothers [29, 30]; however, this difference was not present in mother–newborn pairs who did not go through labor (Fig 1A). In this regard, has been established that irisin secretion is increased by exercise [1, 3]; therefore, the physical stress related to labor [31], possibly mimicking physical activity, might explain the higher irisin levels in those newborns.…”

Section: Discussionsupporting

confidence: 93%

“…We also found no correlation between umbilical artery irisin and gestational age, which is similar to the results of Ebert el al. [29, 38]. Under normal conditions, arterial cord blood protein concentration may be around 28–53% lower than the concentration in maternal serum [40], which is similar to what was found in the current study.…”

Section: Discussionsupporting

confidence: 87%

“…However, irisin levels did not correlate with newborn weight in this study, which differed from the results of Çağlar et al and Baka et al [15, 29]. We also found no correlation between umbilical artery irisin and gestational age, which is similar to the results of Ebert el al.…”

Section: Discussionsupporting

confidence: 51%

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Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn

et al. 2016

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IntroductionIrisin is considered to be a myokine and adipokine that may also participate in reproductive functions, as it increases significantly throughout pregnancy. However, the regulation of circulating irisin and its relationship with other cytokines has not been assessed thus far in pregnant women and their offspring.ObjectiveThe aim of this study was to evaluate differences in irisin and cytokine concentrations between women at the end of pregnancy and their offspring, as well as the relationship between maternal and newborn irisin and maternal and newborn biomarkers.MethodsTwenty-eight mother/newborn pairs were included in this study. The following biomarkers were evaluated in maternal venous and arterial umbilical cord blood samples: irisin, 27 cytokine panel, total antioxidant capacity (TAC), total plasma protein, and free fatty acid concentration.ResultsThe newborns had significantly lower irisin concentrations compared to their mothers (p = 0.03), but this difference was present only in babies born from mothers without labor prior to cesarean section delivery (p = 0.01). No significant differences in maternal and newborn irisin concentrations were found between diabetic and non-diabetic mothers or between overweight/obese and normal weight mothers. A significant positive correlation was found between TAC level and irisin concentration in newborns. Maternal and newborn interleukin (IL)-1β, IL-1RA, IL-5, IL-7, and interferon gamma-induced protein (IP)-10 levels were significantly positively correlated with irisin concentrations in both study groups. In addition, maternal IL1β, IL-5, IL-7, and IP-10 levels positively predicted maternal irisin concentrations. Furthermore, arterial cord blood TAC and IL-1β and IL1-RA levels positively predicted newborn irisin concentrations. Multiple regression analyses showed that maternal IL-13 negatively predicted offspring irisin levels (p = 0.03) and that maternal IL-1β positively predicted newborn irisin concentrations (p = 0.046).ConclusionNo evidence was found that serum irisin concentrations in mothers at pregnancy termination or those of their newborns correlated with maternal body mass index, the presence of diabetes mellitus, or free fatty acid levels. However, the results of this study indicated that cytokines might predict irisin concentration in mothers and their offspring, although interactions between irisin levels during pregnancy and the newborn have not yet been fully elucidated.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 87%

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Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn

et al. 2016

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“…Thus, irisin deficiency in the IUGR fetus may be one of the missing links in the potential molecular pathways, responsible for the increased postnatal susceptibility of IUGR individuals to insulin resistance, obesity and obesity-related metabolic disorders. In accordance, a recent study documented lower umbilical artery irisin levels in pregnancies complicated by as stated "idiopathic (with no apparent cause) IUGR" [33].…”

Section: Accepted Manuscriptsupporting

confidence: 72%

Cord blood irisin at the extremes of fetal growth

et al. 2015

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“…A recent small study of irisin levels in umbilical cord arterial blood revealed positive correlation between irisin and fetal weight, and a statistically significant lower levels of irisin in growth restricted infants [18]. The authors did not find a difference between cord blood venous levels and maternal blood levels of irisin in the same study population.…”

Section: Resultsmentioning

confidence: 80%

Cord blood irisin levels are positively correlated with birth weight in newborn infants

et al. 2015

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Background Irisin is a novel myokine, secreted from skeletal muscle after exercise. Irisin mediates exercise-related energy expenditure by turning white adipose tissue (WAT) into brown adipose tissue (BAT). Thus, irisin is considered as a potential biomarker for obesity and metabolic syndrome. Infants born small for gestational age (SGA) have increased risk for metabolic syndrome. However, the physiologic role of irisin in neonates remains to be studied. Objective To evaluate the association of umbilical cord blood irisin levels with gestational age and birth weight categories in neonates. Methods A cross-sectional study of 341 newborns, from 26 to 41 weeks' gestation. We collected umbilical cord blood and analyzed plasma for irisin by ELISA. Results Plasma irisin levels were positively correlated with gestational age (r=0.21, p<0.001), and birth weight Z-score (r=0.18, p<0.001). SGA infants had significantly lower irisin (median [interquartile range] 55.38 [46.56 - 65.72] ng/mL) compared to appropriate for gestational age infants (64.41 [53.87 - 76.76] ng/mL) and large for gestational age infants (68.70 [54.78 - 79.09] ng/mL, p<0.01). The association between SGA and lower irisin remained significant in multivariate analysis independent of gestational age, maternal age, maternal BMI, and gestational diabetes (p=0.03). In singleton infants, irisin was also significantly negatively associated with maternal preeclampsia (p=0.01). Conclusions Our results support the notion that irisin may have a physiologic role in neonates. We speculate that decreased levels of irisin in SGA infants may contribute to the development of catch up growth and metabolic syndrome later in life.

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Irisin in idiopathic foetal growth restriction

Abstract: The data suggest that umbilical artery irisin levels were lower in pregnancies complicated by foetal growth restriction. Such lower irisin levels may contribute to the pathogenesis of this common condition, and metabolic syndrome may be a long-term consequence of idiopathic FGR.

Cited by 20 publications

References 31 publications

Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn

Relationship between Irisin Concentration and Serum Cytokines in Mother and Newborn

Cord blood irisin at the extremes of fetal growth

Cord blood irisin levels are positively correlated with birth weight in newborn infants

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