Irisin and Triglyceride Glucose Index as Markers of Dyslipidemia in Young Adults

Sagana, M. K. Nilofer; Senghor, K. A. Arul; Vinodhini, V.; P, Renuka

doi:10.1007/s12291-022-01083-3

Cited by 1 publication

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… Triglyceride to HDL ratio [ 14 ], a useful marker of cardiovascular risk applied also in overweight children; this index could be considered increased when >2 [ 15 ]. TyG-BMI [ 16 ], calculated with the following formula: TyG Index × BMI (kg/m 2 ); this derives from the TyG index in association with patient’s BMI; however, there are no specific cut-offs available for its interpretation. Visceral adiposity index (VAI) [ 17 ], calculated as reported in Figure 1 ; it describes how all determinants of the metabolic syndrome increase their absolute value in the presence of a higher VAI (>2.5) [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Cardiometabolic Risk Assessment in a Cohort of Children and Adolescents Diagnosed with Hyperinsulinemia

Sodero,

Rigante,

Pane

et al. 2024

Diseases

View full text Add to dashboard Cite

Background: Individuals with hyperinsulinemia may initially not meet any diagnostic criteria for metabolic syndrome, though displaying a higher risk of cardiovascular complications combined with obesity, diabetes, and hypertension. Aim: The main objective of our study was to assess the diagnostic accuracy of various cardiovascular risk indices in hyperinsulinemic children and adolescents; a secondary objective was to estimate the optimal cut-offs of these indices. Patients and methods: This retrospective single-center study was conducted on 139 patients aged 12.1 ± 2.9 years, managed for hyperinsulinism. Results: We found statistically significant differences in homeostasis model assessment of insulin resistance index (HOMA-IR), triglyceride glucose index (TyG), TyG-body mass index, visceral adiposity index, lipid accumulation product index, fatty liver index, and hepatic steatosis index. At the linear logistic regression assessment, we found that insulin growth factor-1 (IGF-1), HOMA-IR, and ALT/AST ratio were independently associated with confirmed hyperinsulinism. At the multivariate analysis, IGF-1 levels over 203 ng/mL and HOMA-IR higher than 6.2 were respectively associated with a 9- and 18-times higher odds ratio for hyperinsulinism. The other investigated parameters were not significantly related to hyperinsulinism, and could not predict either the presence of hyperinsulinemia or a subsequent cardiovascular risk in our patients. Conclusion: Commonly used indices of cardiovascular risk in adults cannot be considered accurate in confirming hyperinsulinism in children, with the exception of HOMA-IR. Further studies are needed to verify the usefulness of specific cardiovascular risk indices in hyperinsulinemic children and adolescents.

show abstract

Section: Methodsmentioning

confidence: 99%

“…TyG-BMI [ 16 ], calculated with the following formula: TyG Index × BMI (kg/m 2 ); this derives from the TyG index in association with patient’s BMI; however, there are no specific cut-offs available for its interpretation.…”

Section: Methodsmentioning

confidence: 99%