Irisin and Secondary Osteoporosis in Humans

Zerlotin, Roberta; Oranger, Angela; Pignataro, Patrizia; Dicarlo, Manuela; Maselli, Filippo; Mori, Giorgio; Colucci, Silvia; Grano, Maria; Colaianni, Graziana

doi:10.3390/ijms23020690

Cited by 22 publications

(12 citation statements)

References 80 publications

(105 reference statements)

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“…The skeletal muscle secretes various molecules that affect bone including insulin-like growth factor-1 (IGF-1), basic fibroblast growth factor (FGF-2), interleukin-6 (IL-6), IL-15 and myostatin ( 39 ). Furthermore, irisin secreted by skeletal muscle was considered to improve bone health following exercise ( 40 ). Adipocytes also produce leptin, adiponectin and IL-6, which potentially modulate bone metabolisms.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric and visualized analysis of exercise and osteoporosis from 2002 to 2021

Xie²,

Han³

et al. 2022

Front. Med.

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BackgroundBibliometric analysis was designed to investigate a systematic understanding of developments in exercise and osteoporosis research over the past 20 years.MethodsRelevant publications from the Web of Science Core Collection were downloaded on April 26, 2022. CiteSpace, VOSviewer, and the online bibliometric analysis platform were used to conduct this scientometric study.ResultsA total of 5518 publications were in 1202 academic journals with 137405 co-cited references in by 5637 institutions from 98 countries/regions. The country leading the research was the USA. The University of Melbourne was the most active institution. Osteoporosis International was the most productive journal concerning exercise and osteoporosis research. According to the burst references, “low-level vibration,” “high-frequency” and “resistance exercise” have been recognized as the hotspots research in the domain. The keywords co-occurrence analysis identified “skeletal muscle,” “sarcopenia” and “mesenchymal stem cell” as the important future research directions.ConclusionThis study was the first comprehensive metrological and statistical analysis of exercise and osteoporosis research over the past 20 years. Our findings would provide guidance to understand the research frontiers and hot directions in the near future.

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Section: Discussionmentioning

confidence: 99%

Bibliometric and visualized analysis of exercise and osteoporosis from 2002 to 2021

Xie²,

Han³

et al. 2022

Front. Med.

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“…The present research performed on young male volunteers during 10-day BR allowed us to analyze the circulating levels of molecules contributing to the physiological control of musculoskeletal system during and following adaptation to the change in mechanical load and fluid We studied the circulating levels of myokine irisin, whose anabolic role on bone and muscle has been recently demonstrated, [35][36][37] and of myostatin and sclerostin, well-known molecules controlling muscle and bone mass respectively. 38,39 Additionally, as an inflammatory state can arise as a result or outcome of lack of mobility, 40 we also measured the serum haptoglobin levels.…”

Section: Discussionmentioning

confidence: 99%

Impact of 10‐day bed rest on serum levels of irisin and markers of musculoskeletal metabolism

et al. 2022

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The bed rest (BR) is a ground‐based model to simulate microgravity mimicking skeletal‐muscle alterations as in spaceflight. Molecular coupling between bone and muscle might be involved in physiological and pathological conditions. Thus, the new myokine irisin and bone‐muscle turnover markers have been studied during and after 10 days of BR. Ten young male individuals were subjected to 10 days of horizontal BR. Serum concentrations of irisin, myostatin, sclerostin, and haptoglobin were assessed, and muscle tissue gene expression on vastus lateralis biopsies was determined. During 10‐days BR, we observed no significant fluctuation levels of irisin, myostatin, and sclerostin. Two days after BR (R+2), irisin serum levels significantly decreased while myostatin, sclerostin, and haptoglobin were significantly increased compared with BR0. Gene expression of myokines, inflammatory molecules, transcription factors, and markers of muscle atrophy and senescence on muscle biopsies were not altered, suggesting that muscle metabolism of young, healthy subjects is able to adapt to the hypomobility condition during 10‐day BR. However, when subjects were divided according to irisin serum levels at BR9, muscle ring finger‐1 mRNA expression was significantly lower in subjects with higher irisin serum levels, suggesting that this myokine may prevent the triggering of muscle atrophy. Moreover, the negative correlation between p21 mRNA and irisin at BR9 indicated a possible inhibitory effect of the myokine on the senescence marker. In conclusion, irisin could be a prognostic marker of hypomobility‐induced muscle atrophy, and its serum levels could protect against muscle deterioration by preventing and/or delaying the expression of atrophy and senescence cellular markers.

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“…Linked with PGC-1α, exercise-induced myokines may also be used for treating MSD. Among them, there is large evidence linking irisin with bone health [85]. Indeed, irisin administration was reported to improve osteogenesis and fracture recovery, protecting from dexamethasone-induced cell death and disuse-induced bone loss [86].…”

Section: Exercise Mimicking Drugs For the Treatment Of Musculoskeleta...mentioning

confidence: 99%

Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders

Cento

Leigheb

Caretti

et al. 2022

Curr Osteoporos Rep

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Purpose of Review The incidence of musculoskeletal disorders affecting bones, joints, and muscles is dramatically increasing in parallel with the increased longevity of the worldwide population, severely impacting on the individual’s quality of life and on the healthcare costs. Inactivity and sedentary lifestyle are nowadays considered the main drivers of age-associated musculoskeletal disorders and exercise may counteract such alterations also in other bone- and muscle-centered disorders. This review aims at clarifying the potential use of exercise training to improve musculoskeletal health. Recent Findings Both the skeletal muscle and the bone are involved in a complex crosstalk determining, in part through tissue-specific and inflammatory/immune released factors, the occurrence of musculoskeletal disorders. Exercise is able to modulate the levels of those molecules and several associated molecular pathways. Summary Evidence from preclinical and clinical trials supports the adoption of exercise and the future use of exercise mimicking drugs will optimize the care of individuals with musculoskeletal disorders.

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Irisin and Secondary Osteoporosis in Humans

Cited by 22 publications

References 80 publications

Bibliometric and visualized analysis of exercise and osteoporosis from 2002 to 2021

Bibliometric and visualized analysis of exercise and osteoporosis from 2002 to 2021

Impact of 10‐day bed rest on serum levels of irisin and markers of musculoskeletal metabolism

Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders

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